Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase(FKP)in Bacteroides fragilis

作     者：Ying Liu Huifang Hu Jia Wang Qiang Zhou Peng Wu Nieng Yan Hong-Wei Wang Jia-Wei Wu Linfeng Sun 

作者机构：Tsinghua-Peking Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China School of Life SciencesTsinghua UniversityBeijing 100084China Department of Molecular MedicineThe Scripps Research InstituteLa JollaCA 92037USA Ministry of Education Key Laboratory of Protein SciencesBeijing Advaneed Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China State Key Laboratory of Membrane BiologyBeijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China CAS Center for Excellence in Molecular Cell ScienceHefei National Laboratory for Physical Sciences at MicroscaleSchool of Life Scien cesUniversity of Science and Tech no logy of ChinaHefei 230027China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2019年第10卷第5期

页      面：365-369页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：supported by the National Key R&D Program of China 北京市科委项目 the financial support from the NIH the Fundamental Research Funds for the Central Universities 

主　　题：Cryo-EM structure pyrophosphorylase Bacteroides fragilis 

摘      要：Dear Editor,L-Fucose(6-deoxy-L-galactose,fucose)is the basic compone nt of a variety of glyca n *** fucosylated oligosaccharides participate in a variety of cellular activities,like the cell-cell recognition,selectin-mediated leukocyteendothelial adhesion and the formation of Lewis blood group antigens(Ma et al.,2006).GDP-fucose is an important fucose donor in the process of fucosylated oligosaccharides *** pathways of GDP-fucose synthesis are present in the cytosol of mammalian cells,including the de novo pathway and the salvage pathway(Becker et al.,2003).In the salvage pathway,cells use fucose from the extracellular or lysosomal sources to synthesize GDP-fucose.