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Prevalence, risk factors, and braf mutation of colorectal sessile serrated lesions among Vietnamese patients

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World Journal of Clinical Oncology 2024年第2期15卷 290-301页

作者： Nhu Thi Hanh Vu Huy Minh Le Diem Thi-Ngoc Vo Hoang Anh Vu Nhan Quang Le Dung Dang Quy Ho Duc Trong Quach Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam GI Endoscopy Department University Medical Center at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Histology-Embryology and Pathology University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Center for Molecular Biomedicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Endoscopy Cho Ray HospitalHo Chi Minh 700000Viet Nam

BACKGROUND Sessile serrated lesions(SSLs)are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal *** studies in Vietnam mainly investigated the adenoma pathway,with limited data on the serrated *** To evaluate the prevalence,risk factors,and braf mutations of SSLs in the Vietnamese *** This is a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in *** were diagnosed on histopathology according to the 2019 World Health Organi-zation *** mutation analysis was performed using the Sanger DNA sequencing *** multivariate logistic regression model was used to determine SSL-associated *** There were 2489 patients,with a mean age of 52.1±13.1 and a female-to-male ratio of 1:*** prevalence of SSLs was 4.2%[95%confidence interval(CI):3.5-5.1].In the multivariate analysis,factors significantly associated with SSLs were age≥40[odds ratio(OR):3.303;95%CI:1.607-6.790],male sex(OR:2.032;95%CI:1.204-3.429),diabetes mellitus(OR:2.721;95%CI:1.551-4.772),and hypertension(OR:1.650,95%CI:1.045-2.605).The rate of braf mutations in SSLs was 35.5%.CONCLUSION The prevalence of SSLs was 4.2%.braf mutations were present in one-third of *** risk factors for SSLs included age≥40,male sex,diabetes mellitus,and hypertension.

关键词： Colorectal cancer Sessile serrated lesion braf mutation Risk factors Diabetes mellitus Hypertension

Overexpression of miR-221 is associated with aggressive clinicopathologic characteristics and the braf mutation in papillary thyroid carcino-mas

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Overexpression of miR-221 is associated with aggressive clin...

Clinicopathological Features and Prognostic Value of KRAS/NRAS/braf mutations in Colorectal Cancer Patients of Central China

首届浙赣两省肿瘤研究交流会

作者：周毅力戴璇璇张筱骅王瓯晨温州医学院附属一院肿瘤外科

Correlation between clinicopathogenetic features and the expression of specific miRNAs is unclear in papillary thyroid carcinoma(PTC).We therefore sought to assess whether miR-221 was associated with aggressive clinicopathologic characteristics and the braf *** studied the expression levels of miR-221 using northern blot quantitated by scion image in 51 cases of *** status of braf of PTCs was analyzed through direct DNA ***-Whitney U -test was used to analyze different expression of miR-221 in PTCs with distinct clinicopathogenetic characteristics in-cluding gender,age,tumor size,multifocality,extrathyroidal invasion,disease stages,node metastasis and braf *** with the normal thyroid tissues,the relative expression of miR-221 in tumor tissues was significantly upregulated(Pbraf mutation(p=0.014).While among braf wild tumors, miR-221 was only associated with extarthyroidal invasion,it showed strong association with all above aggressive features among braf-mutation ***-221 may be potential importance in determining the aggressive properties of PTCs including the braf mutation and it may further refine the risk stratifi-cation by braf mutation in PTCs.

关键词： Papillary thyroid carcinoma(PTC) miR-221 braf mutation node metastasis

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Current Medical Science 2021年第1期41卷 118-126页

作者： Xiao-na CHANG Fu-mei SHANG Hong-yu JIANG Chen CHEN Zhe-yan ZHAO Sheng-he DENG Jun FAN Xiao-chuan DONG Ming YANG Yan LI Kai-lin CAI Li LIU Hong-li LIU Xiu NIE Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Epidemiology and Biostatistics the Ministry of Education Key Lab of Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

The incidence of colorectal cancer(CRC)is increasing in China,with high ***,we aimed to evaluate the latest clinicopathological features and prognostic value of the KRAS/NRAS/braf mutation status in CRC patients in Central *** clinical data of 1549 CRC patients with stage I-IV disease diagnosed at Union Hospital,Tongji Medical College of Huazhong University of Science and Technology from 2015 to 2017 were collected and analyzed ***/NRAS/braf mutations were detected by real-time quantitative polymerase chain reaction(q-PCR)in 410 CRC patients,with mutation frequencies of KRAS,NRAS and braf of 47.56%,2.93%and 4.15%,*** gene mutation status and clinicopathological characteristics of 410 patients with CRC who underwent qPCR were *** KRAS and braf gene mutations were related to the pathological differentiation and number of metastatic lymph *** braf gene mutation was also associated with cancer thrombosis in blood *** regression analysis showed that there was no statistically significant difference in the overall survival(OS)between patients with KRAS,NRAS mutants and wild-type CRC patients,while the braf gene mutation was negatively correlated with the OS rate of CRC *** is suggested that the braf gene mutation may be an independent risk factor for the prognosis of CRC.

关键词： colorectal cancer KRAS mutation NRAS mutation braf mutation prognosis

Contemporary treatment approaches for metastatic colorectal cancer driven by braf V600 mutations

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1080-1090页

作者： Ozkan Kanat Hulya Ertas Burcu Caner Department of Medical Oncology Acıbadem Bursa HospitalBursa 16059Turkey Department of Medical Oncology Bursa City HospitalBursa 16059Turkey Department of Medical Oncoloy Balıkesir Ataturk City HospitalBursa 16059Turkey

The treatment of metastatic colorectal cancer(mCRC)harboring braf V600 mutations is *** tumors are often refractory to standard ***,the patients may exhibit rapid clinical deterioration,depriving them of the chance to receive salvage *** newly diagnosed patients with good performance status,the administration of an intensive chemotherapy regimen like FOLFOXIRI(5-fluorouracil,leucovorin,oxaliplatin,and irinotecan)along with the antiangiogenic agent bevacizumab can modify this aggressive behavior of the disease and improve patient clinical *** recently published results of the BEACON(Binimetinib,Encorafenib,and Cetuximab Combined to Treat braf-Mutant Colorectal Cancer)study demonstrated that a combination therapy consisting of braf,epidermal growth factor receptor,and mitogen-activated protein kinase kinase inhibitors could be a useful second-or third-line *** review summarizes the current treatment strategies for braf-mutant mCRC.

关键词： braf mutation V600 mutations Metastatic colorectal cancer Targeted therapies

Skeletal muscle metastasis with bone metaplasia from colon cancer:A case report and review of the literature

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World Journal of Clinical Cases 2021年第30期9卷 9285-9294页

作者： Yu Guo Shuang Wang Ze-Yun Zhao Jian-Nan Li An Shang Dong-Lin Li Min Wang Department of General Surgery The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Dermatology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Colon cancer is a common malignant disease of the gastrointestinal tract and usually occurs at the junction of the rectum and sigmoid *** and hematogenous metastases occur frequently in colon cancer and the most common metastatic sites include the liver,lung,peritoneum,bone,and lymph *** a manifestation of advanced tumor spread and metastasis,soft tissue metastasis,especially skeletal muscle metastasis with bone metaplasia caused by colon cancer,is rare,accounting for less than 1%of *** SUMMARY A 43-year-old male patient developed skeletal muscle metastasis with bone metaplasia of the right proximal thigh 5 mo after colon cancer was *** patient was admitted to the hospital because of pain caused by a local mass on his right *** emission tomography-computed tomography showed many enlarged lymph nodes around the abdominal aorta but no signs of lung or liver *** ultrasound revealed a mass located in the skeletal muscle and the results of histological biopsy revealed a poorly differentiated adenocarcinoma suspected to be distant metastases from colon *** showed small woven bone components that were considered to be *** This case reminds us that for patients with advanced colorectal tumors,we should be alert to the possibility of unconventional metastasis.

关键词： Soft tissue metastasis Skeletal muscle metastasis Ossification Colon cancer braf mutation Tumor mutation burden Case report

braf and KRAS mutations in metastatic colorectal cancer:future perspectives for personalized therapy

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Gastroenterology Report 2020年第3期8卷 192-205,I0001页

作者： Zi-Nan Li Lin Zhao Li-Feng Yu Min-Jie Wei Department of Pharmacology School of PharmacyChina Medical UniversityShenyangLiaoningP.R.China Liaoning Engineering Technology Research Center China Medical UniversityShenyangLiaoningP.R.China

Colorectal cancer(CRC)is one of the most commonly diagnosed cancers worldwide and 30%of patients with CRC experience *** with metastatic colorectal cancer(mCRC)have a 5-year overall survival rate ofbraf)and V-Ki-ras2 Kirsten ratsarcoma viral oncogene homolog(KRAS)mutations are mostly studied in mCRC,as clinical trials found that first-line chemotherapy with anti-epidermal growth factor receptor agent confers limited efficacy for *** decisions for early-stage mCRC do not consider braf or KRAS mutations,given the dramatically poor prognosis conferred by these mutations in clinical ***,it is necessary to identify patients with mCRC harboring braf or KRAS mutations to formulate rational therapeutic strategies to improve prognosis and *** and KRAS mutations occur in10%and44%of patients with mCRC,*** the survival rate of patients with mCRC has improved in recent years,the response and prognosis of patients with the aforementioned mutations are still *** is a substantial unmet need for prospective personalized therapies for patients with braf-or KRAS-mutant *** this review,we focus on braf and KRAS mutations to understand the mechanisms underlying resistance and improving the response rate,outcomes,and prognosis of patients with mCRC bearing these mutations and to discuss prospective personalized therapies for braf-and KRAS-mutant mCRC.

关键词： metastatic colorectal cancer epidermal growth factor receptor KRAS mutation braf mutation personalized therapy

Clinicopathologic Characteristics of Differentiated Thyroid Carcinoma in Children and Adolescents

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Advances in Bioscience and Biotechnology 2023年第4期14卷 143-150页

作者： Tianzhi Zhang Chao Liang Guangchang Shan Danting Su Department of Pathology The Seventh Affiliated Hospital of Sun Yat-sen University Shenzhen China

Objective: To investigate the clinicopathologic features of differentiated thyroid carcinoma in children and adolescents. Methods: The clinical data of 7 children and adolescents with differentiated thyroid carcinoma were retrospectively analyzed, and the clinicopathologic features of differentiated thyroid carcinoma were analyzed by gender, tumor size and braf mutation. Results: There were 7 cases of thyroid papillary carcinoma. The mean age of patients was (18.71 ± 2.75), and the mean tumor diameter was (2.4 ± 1.04) cm. Lymph node metastasis rate was 100% (7/7). In children and adolescents, the lesion volume was larger, membrane invasion and vascular cancer thrombus were more likely to occur, braf mutation was less common, and the difference was statistically significant. Conclusion: Children and adolescents with differentiated thyroid carcinoma are more aggressive and prone to membrane invasion and lymph node metastasis;braf mutation is less common than in adults.

关键词： Children and Adolescents Thyroid Papillary Carcinoma Clinicopathological Features braf mutation