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Using multimodal MRI to investigate alterations in brain structure and function in the bbzdr/wor rat model of type 2 diabetes

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Animal Models and Experimental Medicine 2020年第4期3卷 285-294页

作者： Christopher M.Lawson Kilian F.G.Rentrup Xuezhu Cai Praveen P.Kulkarni Craig F.Ferris Center for Translational NeuroImaging Northeastern UniversityBostonMAUSA

Background:This is an exploratory study using multimodal magnetic resonance imaging(MRI)to interrogate the brain of rats with type 2 diabetes(T2DM)as compared to *** was hypothesized there would be changes in brain structure and function that reflected the human disorder,thus providing a model system by which to follow disease progression with noninvasive ***:The transgenic bbzdr/wor rat,an animal model of T2MD,and agematched controls were studied for changes in brain structure using voxel-based morphometry,alteration in white and gray matter microarchitecture using diffusion weighted imaging with indices of anisotropy,and functional coupling using restingstate BOLD functional *** from each modality were registered to,and analyzed,using a 3D MRI rat atlas providing site-specific data on over 168 different brain ***:There was an overall reduction in brain volume focused primarily on the somatosensory cortex,cerebellum,and white matter *** putative changes in white and gray matter microarchitecture were pervasive affecting much of the brain and not localized to any *** was a general increase in connectivity in T2DM rats as compared to *** cerebellum presented with strong functional coupling to pons and brainstem in T2DM rats but negative connectivity to ***:The neuroradiological measures collected in BBBKZ/wor rats using multimodal imaging methods did not reflect those reported for T2DB patients in the *** data would suggest the BBBKZ/wor rat is not an appropriate imaging model for T2DM.

关键词： bbzdr/wor rat diffusion weighted imaging magnetic resonance imaging resting-state BOLD functional imaging small vessel disease voxel-based morphometry

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