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b lymphocyte stimulator： a new target for treating b cell malignancies

Chinese Medical Journal 2008年第14期121卷 1319-1323页

作者： SUN Jian LIN Zhou LI Yan SHEN bei-fen Department of Molecular and Cellular Pharmacology School of Pharmaceutical and Technology Tianjin University Tianjin 300072 China Institute of basic Medical Sciences Academy of Military Medical Sciences Beijing 100850 China

blymphocyte stimulator （bLyS） is also known as b cell activating factor belonging to the tumor necrosis factor （TNF） family （bAFF）, or TNF and apoptosis ligand-related leukocyte-expressed ligand 1 （TALL-I）.^1-3 As a member of the TNF family, bLyS plays an important role in b cell development, and has been implicated in autoimmune diseases and b cell malignancies.

关键词： b lymphocyte stimulator tumor necrosis factor multiple myeloma lymphoma therapy

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Downregulation of b lymphocyte stimulator expression by curcumin in b lymphocyte via suppressing nuclear translocation of NF-κb

Downregulation of B lymphocyte stimulator expression by curc...

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重庆市生物化学与分子生物学学术会议

作者： Gang Huang1,Zhizhen Xu1,Yanchun Yang2,Peng Zhou1,Wei Gong1,Yuan Li1,Jishan Fan1,Fengtian He (1 Department of biochemistry and Molecular biology,College of basic Medical Science,Third Military Medical University,Chongqing 400038 2 Department of Oral and Maxillofacial Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038)

Overexpression of b lymphocyte stimulator(bLyS) is closely with some autoimmune diseases,so bLyS has been proposed to be an important new molecular target for treatment of these diseases. Curcumin,a natural compound isolated from tumeric,has been shown in recent studies to have therapeutic potential in the treatment of autoimmune ***,it is not clear whether curcumin

关键词： b lymphocyte stimulator curcumin NF-κb autoimmune diseases

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Expression of bAFF in the trophoblast and decidua of normal early pregnant women and patients with recurrent spontaneous miscarriage

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Chinese Medical Journal 2008年第4期121卷 309-315页

作者： GUO Wen-jing QU Xun YANG Mei-xiang ZHANG Wei-dong LIANG Lu SHAO Qian-qian KONG bei-hua Department of Obstetrics and Gynecology Qilu Hospital ShandongUniversity Jinan Shandong 250012 China basic Research Institute of Clinic Medicine Qilu Hospital ShandongUniversity Jinan Shandong 250012 China Department of Obstetrics and Gynecology Second Hospital Shandong University Jinan Shandong 250012 China Department of Pathology Institute of Basic Medicine Shandong Academy of Medical Sciences Jinan Shandong 250012 China

background bAFF, the b cell activation factor, is a member of the tumor necrosis factor （TNF） ligand family that binds to bCMA, TACI, and bAFF-R. Previous studies have shown that members of the TNF family are detected in human placental trophoblast cells, but the expression patterns of bAFF involved in human decidua and the differential expression of bAFF between normal pregnancy and miscarriage are still incompletely documented or unknown. This study was designed to investigate the expression of bAFF and bAFF-R in the trophoblast and decidua of normal early pregnant women and recurrent spontaneous abortion （RSA） patients.Methods Forty-five patients with RSA and 45 normal pregnant women were included in this study. by reverse transcriptase-polymerase chain reaction （RT-PCR）, Western blotting and immunohistochemical experiments, we explored the expression of bAFF and bAFF-R in the maternal-fetal interface of normal early pregnant women and RSA patients.Results Analysis by RT-PCR and Western blotting revealed that bAFF was detected in both trophoblast and decidua of all the samples, and the expression level was higher in the tissues of normal early pregnant women （P〈0.05） than that of recurrent spontaneous abortion patients under the same gestational weeks. Messages for bAFF-R were absent. Immunohistochemical experiments showed that expression of bAFF was cell-specific which was localized to villous cytotrophoblast and syncytiotrophoblast cells in trophoblast and to stromal cells in decidua. Whereas bAFF was prominent on the trophoblast and decidua of normal early pregnant women, it was decreased in the tissues of RSA patients.Conclusions bAFF might steer maternal leukocytes away from a harmful immune response and toward a favorable one and play a potentially vital role for successful pregnancy.

关键词： b lymphocyte stimulator recurrent spontaneous abortion maternal-fetal immunology

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biomarkers in kidney transplantation: From bench to bedside

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World Journal of Nephrology 2015年第5期4卷 487-491页

作者： Natavudh Townamchai Somchai Eiam-Ong Division of Nephrology Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Center of Excellence in Solid Organ Transplantation King Chulalongkorn Memorial Hospital

Immunosuppressive drug level monitoring and serum creatinine are widely used for kidney transplantation （KT） monitoring. Monitoring of drug level is not the direct measurement of the immune response while the rising of creatinine is too late for detection of allograft injury. Kidney biopsy, the gold standard for KT monitoring, is invasive and may lead to complications. Many biomarkers have been discovered for direct monitoring of the immune system in KT and the beneft of some biomarkers has reached clinical level. In order to use biomarkers for KT monitoring, physicians have to understand the biology including kinetics of each marker. This can guide biomarker selection for specific condition. Herein, we summarize the recent fndings of donor specifc anti-human leukocyte antigen antibody, b lymphocyte stimulator, interferon-gamma induced protein of 10 kDa, and intracellular adenosine triphosphate monitoring, all of which have very strong evidence support for the clinical use in KT.

关键词： Kidney Transplantation biomarkers Donor specific antibody b-cell b lymphocyte stimulator Interferon induced protein of 10 kDa Intracellular adenosine triphosphate

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