Downregulation of B lymphocyte stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-κB

作     者：Gang Huang1,Zhizhen Xu1,Yanchun Yang2,Peng Zhou1,Wei Gong1,Yuan Li1,Jishan Fan1,Fengtian He (1 Department of Biochemistry and Molecular Biology,College of Basic Medical Science,Third Military Medical University,Chongqing 400038 2 Department of Oral and Maxillofacial Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038) 

会议名称：《重庆市生物化学与分子生物学学术会议》

会议日期：2009年

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

关 键 词：B lymphocyte stimulator curcumin NF-κB autoimmune diseases 

摘      要：Overexpression of B lymphocyte stimulator(BLyS) is closely with some autoimmune diseases,so BLyS has been proposed to be an important new molecular target for treatment of these diseases. Curcumin,a natural compound isolated from tumeric,has been shown in recent studies to have therapeutic potential in the treatment of autoimmune ***,it is not clear whether curcumin