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Case report of a healthy,elderly man with long-term high titers for anti-acetylcholine receptor antibody without myasthenia gravis

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Neural Regeneration Research 2010年第23期5卷 1832-1835页

作者： Jin Jun LUO Nae J. Dun Department of Neurology Temple University School of Medicine Philadelphia PA 19140 USA Department of Pharmacology Temple University School of Medicine Philadelphia PA 19140 USA

Anti-acetylcholine receptor antibodies （AAR） are considered pathognomonic and pathogenetic for myasthenia gravis （MG）. AAR detection confirms clinical diagnosis of MG. However, AAR is rarely detected in patients without MG. The underlying pathophysiological mechanisms in a normal subject without MG have not been adequately addressed in previous studies. The present study reports on a case study of a healthy, elderly man with high AAR titers for 14 years. Pathophysiological mechanisms could be due to AAR heterogeneity in specificity, affinity, and multiform, and to muscle variability in response to AAR.

关键词： myasthenia gravis anti-acetylcholine receptor antibody false-positive antibody autoimmune disorder

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Myasthenia gravis

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Annals of Eye Science 2018年第1期3卷 158-164页

作者： Sayena Jabbehdari Karl C.Golnik Department of Ophthalmology and Visual Sciences University of Illinois at ChicagoChicagoIllinoisUSA Department of Ophthalmology University of Cincinnati and the Cincinnati Eye InstituteCincinnatiOhioUSA

Myasthenia gravis(MG)is an autoimmune antibody-mediated disorder which causes fluctuating weakness in ocular,bulbar and limb skeletal *** are two major clinical types of *** MG(OMG)affects extra ocular muscles associated with eye movement and eyelid function and generalized MG results in muscle weakness throughout the *** with OMG have painless fluctuating extra ocular muscles weakness,diplopia and ptosis accompanied by normal visual acuity and pupillary ***,patients with OMG develop generalized MG over 24 *** OMG is more often earlier in onset(disorder or paraneoplastic syndrome related to thymus *** is based on clinical manifestations,laboratory findings,electrophysiological evaluation and pharmacologic *** strategies for MG consist of symptom relieving medications(e.g.,acetylcholine esterase inhibitors),immunosuppressive agents,and surgical intervention(e.g.,thymectomy).

关键词： Myasthenia gravis(MG) autoimmune disorder neuro-ophthalmology

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Dubin-Johnson syndrome with systemic lupus erythematosus: a case report

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 617-619页

作者： Mamun-Al Mahtab Md. Fazal Karim Salimur Rahman Abul Barkat Muhammad Adnan Department of Hepatology Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

BACKGROUND: Dubin-Johnson syndrome (DJS) is a rare clinical entity. We describe a case of DJS complicated by systemic lupus erythematosus (SLE). METHODS: A case of congenital hyperbilirubinemia with SLE was evaluated systematically including review of history, physical examination for the stigmata of chronic liver disease, and other investigations. RESULT: Liver biopsy revealed a black liver with preserved architecture suggestive of DJS. CONCLUSIONS: SLE may develop in DJS. The relationship between DJS and SLE in this case is most likely a chance occurrence.

关键词： Dubin-Johnson syndrome systemic lupus erythematosus conjugated hyperbilirubinemia autoimmune disorder chance occurrence

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An Extensive Review of Vitiligo-Associated Conditions

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International Journal of Dermatology and Venereology 2024年第1期7卷 44-51页

作者： Madhavi Premkumar Iyshwarya Bhaskar Kalarani Vajagathali Mohammed Ramakrishnan Veerabathiran Human Cytogenetics and Genomics Laboratory Faculty of Allied Health SciencesChettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkamTamil Nadu 603103India

Vitiligo is an autoimmune disorder caused by the destruction of melanocytes in various body *** diseases may accompany *** prevalence of vitiligo varies among geographical regions and shows no relation to sex or ***,vitiligo most commonly affects people aged 10 to 30 *** clinical symptoms of vitiligo include irregular patches on the skin and various diseases associated with this *** present review focuses on the clinical effects and risk factors of vitiligo-associated conditions and the current therapeutics for treating *** systematic review was performed based on the PRISMA guidelines and articles published from 2000 to 2023 in Web of Science,PubMed,PsycINFO,and *** most clinically significant diseases associated with vitiligo are alopecia areata,autoimmune thyroid disease,Addison disease,and type 1 diabetes *** targeted population is specifically prone to vitiligo;it does not affect any particular race or ***,awareness of the diseases associated with vitiligo is necessary to control them through various medical and surgical treatments with the proper facilities.

关键词： vitiligo autoimmune disorder melanocyte Addison disease atopic dermatitis

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Prevalence of malignant neoplasms in celiac disease patients-a nationwide United States population-based study

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World Journal of Clinical Oncology 2024年第8期15卷 1048-1060页

作者： Maryam Bilal Haider Ali Al Sbihi Sushmitha Nanja Reddy Peter Green Department of Gastroenterology Northshore University Health SystemEvanstonIL 60201United States Department of Hematology/Oncology University of Miami Miller School of MedicineMiamiFL 33101United States Department of Hematology/Oncology Karmanos Cancer Institute/Wayne State UniversityDetroitMI 48235United States Celiac Disease Center Columbia UniversityNew YorkNY 10032United States

BACKGROUND Celiac disease(CeD)is an autoimmune disorder triggered by the immune response to gluten in genetically predisposed *** research has unveiled a heightened risk of developing specific malignant neoplasms(MN)and various malignancies,including gastrointestinal,lymphomas,skin,and others,in individuals with *** To investigate the prevalence of MN in hospitalized CeD patients in the United *** Using data from the National Inpatient Sample spanning two decades,from January 2000 to December 2019,we identified 529842 CeD patients,of which 78128(14.75%)had *** score matching,based on age,sex,race,and calendar year,was employed to compare CeD patients with the general non-CeD population at a 1:1 *** Positive associations were observed for several malignancies,including small intestine,lymphoma,nonmelanoma skin,liver,melanoma skin,pancreas myelodysplastic syndrome,biliary,stomach,and other neuroendocrine tumors(excluding small and large intestine malignant carcinoid),leukemia,uterus,and ***,CeD patients exhibited a reduced risk of respiratory and secondary ***,certain malignancies showed null associations with CeD,including head and neck,nervous system,esophagus,colorectal,anus,breast,malignant carcinoids,bone and connective tissues,myeloma,cervix,and ovary *** Our study is unique in highlighting the detailed results of positive,negative,or null associations between different hematologic and solid malignancies and ***,it offers insights into evolving trends in CeD hospital outcomes,shedding light on advancements in its management over the past two *** findings contribute valuable information to the understanding of CeD’s impact on health and healthcare utilization.

关键词： Celiac disease Malignant neoplasm autoimmune disorder Hospitalized patients Healthcare utilization Gastrointestinal malignancies Lymphomas Epidemiology

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