Prevalence of malignant neoplasms in celiac disease patients-a nationwide United States population-based study
作者机构：Department of GastroenterologyNorthshore University Health SystemEvanstonIL 60201United States Department of Hematology/OncologyUniversity of Miami Miller School of MedicineMiamiFL 33101United States Department of Hematology/OncologyKarmanos Cancer Institute/Wayne State UniversityDetroitMI 48235United States Celiac Disease CenterColumbia UniversityNew YorkNY 10032United States
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2024年第15卷第8期
页 面：1048-1060页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Celiac disease Malignant neoplasm Autoimmune disorder Hospitalized patients Healthcare utilization Gastrointestinal malignancies Lymphomas Epidemiology
摘 要：BACKGROUND Celiac disease(CeD)is an autoimmune disorder triggered by the immune response to gluten in genetically predisposed *** research has unveiled a heightened risk of developing specific malignant neoplasms(MN)and various malignancies,including gastrointestinal,lymphomas,skin,and others,in individuals with *** To investigate the prevalence of MN in hospitalized CeD patients in the United *** Using data from the National Inpatient Sample spanning two decades,from January 2000 to December 2019,we identified 529842 CeD patients,of which 78128(14.75%)had *** score matching,based on age,sex,race,and calendar year,was employed to compare CeD patients with the general non-CeD population at a 1:1 *** Positive associations were observed for several malignancies,including small intestine,lymphoma,nonmelanoma skin,liver,melanoma skin,pancreas myelodysplastic syndrome,biliary,stomach,and other neuroendocrine tumors(excluding small and large intestine malignant carcinoid),leukemia,uterus,and ***,CeD patients exhibited a reduced risk of respiratory and secondary ***,certain malignancies showed null associations with CeD,including head and neck,nervous system,esophagus,colorectal,anus,breast,malignant carcinoids,bone and connective tissues,myeloma,cervix,and ovary *** Our study is unique in highlighting the detailed results of positive,negative,or null associations between different hematologic and solid malignancies and ***,it offers insights into evolving trends in CeD hospital outcomes,shedding light on advancements in its management over the past two *** findings contribute valuable information to the understanding of CeD’s impact on health and healthcare utilization.
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