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Clarifying the relationship and analyzing the influential factors of bronchial asthma in children with attention-deficit hyperactivity disorder

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World Journal of Psychiatry 2024年第4期14卷 513-522页

作者： Gui-Xia Wang Xiao-Ying Xu Xi-Qing Wu Department of Infectious Diseases Dongying People’s HospitalDongying 257000Shandong ProvinceChina Department of Children's Health Dongying People’s HospitalDongying 257000Shandong ProvinceChina Department of Children's Health Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina

BACKGROUND Bronchial asthma is closely related to the occurrence of attention-deficit hyperactivity disorder(ADHD)in children,which can easily have adverse effects on children’s learning and social *** have shown that childhood asthma can increase the risk of ADHD and the core symptoms of *** with children with ADHD alone,children with asthma and ADHD are more likely to show high levels of hyperactivity,hyperactive-impulsive and other externalizing behaviors and anxiety in clinical practice and have more symptoms of somatization and emotional *** To explore the relationship between ADHD in children and bronchial asthma and to analyze its influencing *** This retrospective cohort study was conducted at Dongying People's Hospital from September 2018 to August *** diagnosed with ADHD at this hospital were selected as the ADHD group,while healthy children without ADHD who underwent physical examinations during the same period served as the control *** and parental data were collected for all participating children,and multivariate logistic regression analysis was employed to identify risk factors for comorbid asthma in children with *** differences were detected between the ADHD group and the control group in terms of family history ofasthma and allergic diseases, maternal complications during pregnancy, maternal use of asthma and allergymedications during pregnancy, maternal anxiety and depression during pregnancy, and parental relationshipstatus (P < 0.05). Out of the 183 children in the ADHD group, 25 had comorbid asthma, resulting in a comorbidityrate of 13.66% (25/183), compared to the comorbidity rate of 2.91% (16/549) among the 549 children in the controlgroup. The difference in the asthma comorbidity rate between the two groups was statistically significant (P <0.05). The results of the multivariate logistic regression analysis indicated that family history of asthma

关键词： attention-deficit hyperactivity disorder Children Bronchial asthma Risk factors Anxiety Depression

Deficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice

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Zoological Research 2022年第5期43卷 851-870页

作者： Wan-Jun Bai Xing-Guang Luo Bao-Hua Jin Kang-Sheng Zhu Wen-Yan Guo Xiao-Que Zhu Xia Qin Zu-Xiao Yang Jiao-Jiao Zhao Si-Ruan Chen Ri Wang Jie Hao Fei Wang Yun Stone Shi De-Zhi Kong Wei Zhang Department of Pharmacology Institution of Chinese Integrative MedicineKey Laboratory of Neural and Vascular BiologyMinistry of EducationKey Laboratory of New Drug Pharmacology and ToxicologyHebei Medical UniversityResearch Unit of Digestive Tract Microecosystem Pharmacology and ToxicologyChinese Academy of Medical SciencesShijiazhuangHebei 050017China Department of Pharmacy Hebei General HospitalShijiazhuangHebei 050051China Beijing Huilongguan Hospital Peking University Huilongguan School of Clinical MedicineBeijing 100096China Fourth Hospital of Hebei Medical University ShijiazhuangHebei 050017China Department of Psychiatry Affiliated Nanjing Brain HospitalNanjing Medical UniversityNanjingJiangsu 210029China State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study Model Animal Research CenterNanjing UniversityNanjingJiangsu 210061China

attention-deficit hyperactivity disorder(ADHD) is a neurodevelopmental disorder prevalent in schoolage children. At present, however, its etiologies and risk factors are unknown. Transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid(AMPA) receptor regulatory protein γ-8(TARP γ-8,also known as calcium voltage-gated channel auxiliary subunit gamma 8(CACNG8)) is an auxiliary AMPA receptor(AMPAR) subunit. Here, we report an association between TARP γ-8 and ADHD,whereby adolescent TARP γ-8 knockout(KO) mice exhibitedADHD-likebehaviors,including hyperactivity, impulsivity, anxiety, impaired cognition,and memory deficits. Human single-nucleotide polymorphism(SNP) analysis also revealed strong associations between intronic alleles in CACNG8genes and ADHD susceptibility. In addition,synaptosomal proteomic analysis revealed dysfunction of the AMPA glutamate receptor complex in the hippocampi of TARP γ-8 KO *** analysis also revealed dysregulation of dopaminergic and glutamatergic transmissions in the prefrontal cortices of TARP γ-8 KO ***(MPH), which is commonly used to treat ADHD, significantly rescued the major behavioral deficits and abnormal synaptosomal proteins in TARP γ-8 KO mice. Notably, MPH significantly reversed the up-regulation of Grik2 and Slc6a3 in the prefrontal cortex. MPH also significantly improved synaptic AMPAR complex function by up-regulating other AMPAR auxiliary proteins in hippocampal synaptosomes. Taken together, our results suggest that TARP γ-8 is involved in the development of ADHD in *** study provides a useful alternative animal model with ADHD-like phenotypes related to TARP γ-8deficiency, which has great potential for the development of new therapies.

关键词： attention-deficit hyperactivity disorder TARPγ-8 Methylphenidate Proteomics Phenome-wide association study

Diet and food in attention-deficit hyperactivity disorder

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Journal of Future Foods 2022年第2期2卷 112-118页

作者： Klaus W.Lange Yukiko Nakamura Andreas Reissmann Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Deficiencies of nutrients,including vitamins,minerals and polyunsaturated fatty acids,and surpluses of food items,such as sucrose and artificial food additives,have not convincingly been shown to be involved in the etiology of *** group level,there is no conclusive evidence supporting dietary interventions for the treatment of *** identification of a role of food compounds in ADHD is hindered by the complex and ill-defined nature of *** view of the heterogeneity of the disorder,potential therapeutic benefits of nutritional interventions could be confined to subpopulations of children with ADHD as yet *** cumulative benefits of the range of ingredients comprising healthy diets may result in better outcomes compared to a supplementation of individual *** and nutrition interact with other lifestyle factors,such as physical activity,and the interrelationship between nutrition and lifestyle should play a more prominent role in research on treatment approaches to *** few-foods or oligoallergenic diet allows the design of individually tailored diets and may offer treatment opportunities in subgroups of children diagnosed with *** research is required to demonstrate the utility of nutrition-related interventions alone or in combination with other treatment approaches in ADHD.

关键词： attention-deficit hyperactivity disorder Dietary patterns Food Nutrition Oligoallergenic diet

Voxel-based statistical analysis of regional cerebral glucose metabolism in children with attention-deficit hyperactivity disorder

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Neural Regeneration Research 2011年第36期6卷 2850-2855页

作者： Ji-Hoon Kim Young-In Chung Jung Sub Lee In-Joo Kim Yong-Ki Kim Seong-Jang Kim Division of Child-Adolescent Psychiatry Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Medical Research Institute Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Orthopedic Surgery Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Nuclear Medicine Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea

The technique of region of interest-based positron emission tomography is limited by its poor reli-ability and relatively few examined brain regions. In the present study, we compared brain metabo-lism assessed using fluorine-18-fluorodeoxyglucose positron emission tomography between 14 at-tention-deficit hyperactivity disorder （ADHD） patients and 15 normal controls with scoliosis at resting state by statistical parametric mapping. Glucose metabolism was decreased in the left parahippo-campal gyrus, left hippocampus, left anterior cingulate gyrus, right anterior and posterior lobes of the cerebellum, left superior temporal gyrus, left insula, left medial and middle frontal gyri, right medial frontal gyrus, and left basal ganglia （putamen, amygdala, and caudate nucleus） in children with ADHD. These data suggest that children with ADHD exhibit hypometabolism in various brain regions compared to controls, indicating that ADHD symptoms are unlikely the result of abnormalities in specific areas.

关键词： attention-deficit hyperactivity disorder positron emission tomography statistical parametric mapping

A retrospective study on professor Gui-Qi Xuan’s experience in traditional Chinese medicine treatment on attention-deficit hyperactivity disorder: based on data mining and network pharmacology

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Life Research 2023年第3期6卷 10-24页

作者： Jue Hu Dan-Fei Chen Fang-Fang Li Nuo Chen Chun-Lu Ye Ke-Pin Yu Xiao-Bo Xuan Gui-Qi Xuan Jian Chen First Clinical School Zhejiang Chinese Medical UniversityHangzhou 310053China Pediatrics Department of Traditional Chinese Medicine Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006China

Background:To investigate the clinical medication approach of Professor Guiqi Xuan(***)in treating pediatric patients with attention-deficit hyperactivity disorder(ADHD)and the potential mechanism of the core herbal ***:Following medical record information pretreatment,the Traditional Chinese Medicine(TCM)inheritance computing platform system V3.0 was utilized to analyze the standardized *** associate rules were summarized to identify the core prescription for treating *** extracted core herbal prescription’s active compounds and potential targets were used to establish a protein-protein interaction network of active ingredient-disease *** 3.9.1 software was used to analyze the network’s topological parameters to obtain the key active ingredients and their *** Bioconductor data package of R4.0.2 was used to analyze the gene ontology biological functions and Kyoto Encyclopedia of Genes and Genomes pathways of key ***:Two hundred and twenty-seven entries derived from TCM record information were *** data mining,it was found that 62.5%of pediatric patients had short-tempered behavior,nearly half had sleep problems,and 30%-40%had picky eating and polyphagia *** highest-frequency syndrome type was kidney deficiency and liver ***,fire,phlegm,and dyspeptic food were the main pathological factors for ***’s treatment of ADHD mainly focused on replenishing kidney essence and subduing Yang(active,external,ascending,warm,bright,functional and excited pertain to Yang).The core herbal prescription for ADHD included Yuan-zhi,Yi-zhi,Gui-jia,Bai-shao,Long-chi,Ci-shi,Shi-chang-pu,Yu-jin,Fu-shen,and *** protein-protein interaction network showed that MAOA,ADRB2,FOS,MAOB,and SLC6A3 were the five key targets essential in treating ADHD with core herbal *** gene ontology biological function of crucial targets mainly involved G protein-coupled amine

关键词： Chinese traditional medicine Data mining Retrospective clinical studies Network pharmacology attention-deficit hyperactivity disorder Mechanism of action

Transcranial Direct Current Stimulation in ADHD:A Systematic Review of Efficacy,Safety,and Protocol-induced Electrical Field Modeling Results

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Neuroscience Bulletin 2020年第10期36卷 1191-1212页

作者： Mohammad Ali Salehinejad Vahid Nejati Mohsen Mosayebi-Samani Ali Mohammadi Miles Wischnewski Min-Fang Kuo Alessio Avenanti Carmelo M・Vicario Michael A.Nitsche Department of Psychology and Neurosciences Leibniz Research Centre for Working Environment and Human Factors44139 DortmundGermany International Graduate School of Neuroscience Ruhr-University Bochum44801 BochumGermany Institute for Cognitive and Brain Sciences Shahid Beheshti UniversityTehran ***Iran Department of Psychology Shahid Beheshti UniversityTehran ***Iran Institute of Biomedical Engineering and Informatics Ilmenau University of Technology98693 IlmenauGermany Donders Institute for Brain Cognition and BehaviourRadboud University6525 HR NijmegenThe Netherlands Centro studi e ricerche in Neuroscienze Cognitive Dipartimento di PsicologiaAlma Mater StudiormUniversita di Bologna47521 CesenaItaly Centro de Investigacion en Neuropsicologia y Neurociencias Cognitivas Universidad Catolica del Maule3605 TalcaChile Dipartimento di Scienze Cognitive PsicologichePedagogiche e degli studi culturaliUniversita di Messina98121 MessinaItaly Department of Neurology University Medical Hospital Bergmannsheil44789 BochumGermany

Transcranial direct current stimulation(tDCS)is a promising method for altering cortical excitability with clinical *** has been increasingly used in neurodevelopmental disorders,especially attention-deficit hyperactivity disorder(ADHD),but its efficacy(based on effect size calculations),safety,and stimulation parameters have not been systematically *** this systematic review,we aimed to(1)explore the effectiveness of tDCS on the clinical symptoms and neuropsychological deficits of ADHD patients,(2)evaluate the safety of tDCS application,especially in children with ADHD,(3)model the electrical field intensity in the target regions based on the commonly-applied and effective versus less-effective protocols,and(4)discuss and propose advanced tDCS *** the Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach,a literature search identified 14 empirical experiments investigating tDCS effects in *** improving effects of tDCS on cognitive deficits(response inhibition,working memory,attention,and cognitive flexibility)or clinical symptoms(e.g.,impulsivity and inattention)are reported in10 *** serious adverse effects are reported in 747 sessions of *** left and right dorsolateral prefrontal cortex are the regions most often targeted,and anodal tDCS the protocol most often *** intensity of 2 mA induced stronger electrical fields than 1 mA in adults with ADHD and was associated with significant behavioral *** ADHD children,however,the electrical field induced by 1 mA,which is likely larger than the electrical field induced by 1 mA in adults due to the smaller head size of children,was sufficient to result in significant behavioral ***,tDCS seems to be a promising method for improving ADHD ***,the clinical utility of tDCS in ADHD cannot yet be concluded and requires further systematic investigation in larger sample *** regions involved in ADHD pathophysio

关键词： Transcranial direct current stimulation attention-deficit hyperactivity disorder Dorsolateral prefrontal cortex Executive function Systematic review Brain modeling Non-invasive brain stimulation Pediatric