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attention deficit hyperactivity disorder in children with epilepsy:a multicenter cross-sectional analysis in China

World Journal of Pediatrics 2024年第10期20卷 1070-1078页

作者： Gang Pan Ying Han Tian-Cheng Wang Zi-Yi Chen Xiang-Qing Wang Hong-Bin Sun Yong-Hong Liu Qun Wang Wei-Hong Lin Jin-Mei Li Shui-Zhen Zhou Yue-Hua Zhang Department of Neurology Children’s Hospital of Fudan University399 Wan Yuan RoadMinhang DistrictShanghaiChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Neurology Lanzhou University Second HospitalLanzhouChina Department of Neurology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Department of Neurology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Neurology Sichuan Provincial People HospitalChengduChina Department of Neurology Xijing HospitalFourth Military Medical UniversityXi’anChina Department of Neurology Beijing Tiantan HospitalCaptial Medical UniversityBeijingChina Department of Neurology The First Hospital of Jilin UniversityChangchunChina Department of Neurology Sichuan University West China HospitalChengduChina

Background The diagnosis and treatment of attention deficit hyperactivity disorder(ADHD)comorbid with epilepsy have been insufficiently addressed in *** conducted a study in China to investigate the current status,diagnosis,and treatment of ADHD in children to further our understanding of ADHD comorbid with epilepsy,strengthen its management,and improve patients’quality of *** We carried out a multicenter cross-sectional survey of children with epilepsy across China between March 2022 and August *** screened all patients for ADHD and compared various demographic and clinical factors between children with and without ADHD,including gender,age,age at epilepsy onset,duration of epilepsy,seizure types,seizure frequency,presence of epileptiform discharges,and treatment *** objective was to explore any possible associations between these characteristics and the prevalence of *** Overall,395 epilepsy patients aged 6–18 years were *** age at seizure onset and duration of epilepsy ranged from 0.1–18 to 0.5–15 years,*** onset seizures were observed in 212(53.6%)patients,while 293(76.3%)patients had epileptiform interictal electroencephalogram(EEG)*** the 370 patients treated with anti-seizure medications,200(54.1%)had *** 189(47.8%)patients had ADHD,only 31 received treatment for it,with the inattentive subtype being the most *** was more common in children undergoing polytherapy compared to those on ***,poor seizure control and the presence of epileptiform interictal EEG abnormalities may be associated with a higher prevalence of *** While the prevalence of ADHD was higher in children with epilepsy than in normal children,the treatment rate was notably *** highlights the need to give more importance to the diagnosis and treatment of ADHD in children with epilepsy.

关键词： attention deficit hyperactivity disorder Children China Epilepsy Electroencephalogram

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MicroRNAs as potential biomarkers for diagnosis of attention deficit hyperactivity disorder

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Neural Regeneration Research 2024年第3期19卷 557-562页

作者： Bridget Martinez Philip V.Peplow Department of Pharmacology University of Nevada-RenoRenoUSA Department of Medicine University of Nevada-RenoRenoUSA Department of Anatomy University of OtagoDunedinNew Zealand

Inappropriate levels of hyperactivity,impulsivity,and inattention characterize attention deficit hyperactivity disorder,a common childhood-onset neuropsychiatric *** cognitive function and learning ability of children with attention deficit hyperactivity disorder are affected,and these symptoms may persist to adulthood if they are not *** diagnosis of attention deficit hyperactivity disorder is only based on symptoms and objective tests for attention deficit hyperactivity disorder are *** for attention deficit hyperactivity disorder in children include medications,behavior therapy,counseling,and education services which can relieve many of the symptoms of attention deficit hyperactivity disorder but cannot cure *** is a need for a molecular biomarker to distinguish attention deficit hyperactivity disorder from healthy subjects and other neurological conditions,which would allow for an earlier and more accurate diagnosis and appropriate treatment to be *** expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of attention deficit hyperactivity *** recent studies reviewed had performed microRNA profiling in whole blood,white blood cells,blood plasma,and blood serum of children with attention deficit hyperactivity disorder.A large number of microRNAs were dysregulated when compared to healthy controls and with some overlap between individual *** the studies that had included a validation set of patients and controls,potential candidate biomarkers for attention deficit hyperactivity disorder in children could be miR-140-3p,let-7g-5p,-30e-5p,-223-3p,-142-5p,-486-5p,-151a-3p,-151a-5p,and-126-5p in total white blood cells,and miR-4516,-6090,-4763-3p,-4281,-4466,-101-3p,-130a-3p,-138-5p,-195-5p,and-106b-5p in blood *** studies are warranted with children and adults with attention deficit hyperactivity disorder,and

关键词： adults attention deficit hyperactivity disorder biomarkers blood plasma blood serum children microRNA total white blood cells whole blood

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The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in attention deficit hyperactivity disorder with Comorbid Disruptive Behavior disorder

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Neuroscience Bulletin 2018年第3期34卷 566-572页

作者： Yuncheng Zhu Xixi Jiang Weidong Ji Shanghai Changning Mental Health Center Affiliated Greenland Hospital of BIO-X Institute Shanghai Jiao Tong University

The neurocircuitries that constitute the corticostriato-thalamo-cortical（CSTC） circuit provide a framework for bridging gaps between neuroscience and executive function in attention deficit hyperactivity disorder（ADHD）, but it has been difficult to identify the mechanisms for regulating emotional problems from the understanding of ADHD comorbidity with disruptive behavior disorders（DBD）. Research based on ＂cool＇＇ and ＂hot＇＇executive functional theory and the dual pathway models,which are thought of as applied response inhibition and delay aversion, respectively, within the neuropsychological view of ADHD, has shed light on emotional responding before and after decontextualized stimuli, while CSTC circuit-related domains have been suggested to explain the different emotional symptoms of ADHD with or without comorbid DBD. This review discusses the role of abnormal connections in each CSTC circuit, especially in the emotion circuit, which may be responsible for targeted executive dysfunction at the neuroscience level. Thus, the two major domains – abstract thinking（cool） and emotional trait（hot） – trigger the mechanism of onset of ADHD.

关键词： attention deficit hyperactivity disorder Disruptive behavior disorder Emotion Executive function

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A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder

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World Journal of Pediatrics 2022年第12期18卷 825-834页

作者： Mahasweta Chatterjee Sharmistha Saha Swagata Sinha Kanchan Mukhopadhyay Manovikas Biomedical Research and Diagnostic Centre Manovikas Kendra482 MadudahPlot I-24Sector JEM BypassKolkataWest Bengal700107India

Background The serotonin transporter(SERT),encoded by the solute carrier family 6 number 4(SLC6A4)gene,controls serotonin(5-HT)availability and is essential for the regulation of behavioral *** SLC6A4 genetic variants,5-HTTLPR and STin2,were widely investigated in patients with various neurobehavioral disorders,including attention deficit hyperactivity disorder(ADHD).Methods We analyzed the association of the 5-HTTLPR(L/S)and STin2(10/12)variants,plasma 5-HT,and 5-hydroxyindole acetic acid(5-HIAA),as well as SERT messenger RNA(mRNA)with ADHD in the eastern Indian *** families with ADHD probands(n=274)and ethnically matched controls(n=367)were recruited following the Diagnostic and Statistical Manual of Mental *** traits,executive function,and intelligence quotient(IQ)of the probands were assessed using the Conner's Parent Rating Scale–Revised,Parental Account of Children’s Symptoms(PACS),Barkley deficit in Executive Functioning—Child and Adolescent Scale,and Wechsler Intelligence Scale for Children-III,*** obtaining informed written consent,peripheral blood was collected to analyze genetic variants,plasma 5-HT,5-HIAA,and SERT mRNA *** ADHD probands showed a higher frequency of the 5-HTTLPR“L”allele and“L/L”genotype(Phyperactivity were higher in the presence of the“S”allele and“S/S”genotype,while executive deficit was higher in the presence of the“L”*** score was lower in the presence of the STin2“12”allele and L-12 *** Data obtained indicate a significant association of the serotoninergic system with ADHD,warranting further in-depth investigation.

关键词： attention deficit hyperactivity disorder 5-Hydroxyindole acetic acid 5-Serotonin 5-HTT-linked polymorphic region SERT mRNA

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Serum ferritin levels in children with attention deficit hyperactivity disorder and tic disorder

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World Journal of Clinical Cases 2022年第22期10卷 7749-7759页

作者： Cai-Yun Tang Fang Wen Department of Psychiatry Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

BACKGROUND Iron plays an important role in neurodevelopmental functions in the *** ferritin levels are different in children with attention deficit hyperactivity disorder and tic disorder than in healthy *** To explore the current status of iron deficiency in children with neurodevelopmental disorders and its sex and age *** A total of 1565 children with attention deficit hyperactivity disorder(ADHD),1694 children with tic disorder(TD),93 children with ASD and 1997 healthy control children were included between January 1,2020,and December 31,2021 at Beijing Children's *** describe the differences in age levels and ferritin levels between different disease groups and their sex *** differences between the sexes in each disease were analyzed using the t *** incidence rate of low serum ferritin was used to describe the differences between different diseases and different age groups.A chi-square test was used to analyze the difference in the incidence of low serum ferritin between the disease group and the control *** of variance was used for comparisons between subgroups,and regression analysis was used for confounding factor *** A total of 1565 ADHD patients aged 5-12 years were included in this study,and the average serum ferritin levels of male and female children were 36.82±20.64μg/L and 35.64±18.56μg/L,respectively.A total of 1694 TD patients aged 5-12 years were included in this study,and the average serum ferritin levels of male and female children were 35.72±20.15μg/L and 34.54±22.12μg/L,*** age increased,the incidence of low serum ferritin in ADHD and TD first decreased and then increased,and 10 years old was the turning point of rising *** incidence of ADHD with low serum ferritin was 8.37%,the incidence of TD with low serum ferritin was 11.04%,and the incidence of the healthy control group with low serum ferritin was 8.61%,among which male children with TD accounte

关键词： Iron deficiency attention deficit hyperactivity disorder Tic disorder Serum ferritin levels Retrospective study

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Convergence mechanism of mindfulness intervention in treating attention deficit hyperactivity disorder:Clues from current evidence

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World Journal of Clinical Cases 2022年第26期10卷 9219-9227页

作者： Xin-Peng Xu Wei Wang Song Wan Chun-Feng Xiao Universal Scientific Education and Research Network Beijing 100088China Beijing Anding Hospital Capital Medical UniversityBeijing 100088China

This paper reviews the underlying evidence for various aspects of the convergence mechanism of mindfulness intervention in attention deficit hyperactivity disorder(ADHD).There may be compatibility among various ADHD remission models and the therapeutic mechanism of mindfulness intervention in ADHD may be mainly via the convergence ***,neuroimaging-based analysis of the mechanisms of mindfulness intervention in treating ADHD is *** in the efficacy of various subtypes of mindfulness intervention,and corresponding specific imaging changes need further *** research may focus on the neuroimaging features of specific mindfulness intervention subtypes.

关键词： attention deficit hyperactivity disorder Mindfulness Psychological intervention Mechanism

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Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder

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Asian Pacific Journal of Tropical Biomedicine 2021年第3期11卷 105-114页

作者： Khushboo G Faldu Snehal S Patel Jigna S Shah Zydus Research Centre Cadila Healthcare Ltd.AhmedabadGujaratIndia Department of Pharmacology Institute of PharmacyNirma UniversityAhmedabadGujaratIndia

Objective:To explore the effect and mechanism of action of Celastrus paniculatus oil on the treatment of perinatal rats with attention deficit hyperactivity ***:In the perinatal stage,the rats were either isolated or administered with lead acetate to establish an animal model of attention deficit hyperactivity *** served as the reference ***’behaviours were assessed through Y-maze,novel object preference,fear conditioning and residentintruder aggression *** stress parameters,bioamine concentration(dopamine,noradrenaline and 5-hydroxytryptamine),nerve growth factor,interleukin-6,nuclear factor-κB,and tumour necrosis factor(TNF)-αwere *** immunohistochemical assay was ***:Celastrus paniculatus oil significantly improved behavioural parameters in Y maze,novel object preference,discrimination index,fear conditioning and resident intruder aggressive *** treatment groups showed a decrease in malondialdehyde *** in the levels of dopamine,noradrenaline,and serotonin were restored by Celastrus paniculatus *** paniculatus oil increased nerve growth factor and decreased interleukin-6,nuclear factor-κB,and TNF-α.Synaptophysin immunoreactivity was also improved by Celastrus paniculatus oil with alleviated reactive gliosis,degeneration,and vascular ***:This research shows the therapeutic potential of Celastrus paniculatus oil for the treatment of attention deficit hyperactivity disorder.

关键词： attention deficit hyperactivity disorder Celastrus paniculatus Biogenic amines Synaptophysin Nerve growth factor

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Association of Serotonin Receptors with attention deficit hyperactivity disorder： A Systematic Review and Meta-analysis

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Current Medical Science 2018年第3期38卷 538-551页

作者： Yu-wei HOU Ping XIONG Xue GU Xin HUANG Min WANG Jing WU Key Laboratory of Environment and Health Ministry of Education & Department of Epidemiology and Biostatistics School of Public Health Tongii Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Rehabilitation Wuhan Children's Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430015 China

attention deficit hyperactivity disorder （ADHD） is one of the most common mental disorders in childhood, with a high heritability about 60% to 90%. Serotonin is a monoamine neurotransmitter. Numerous studies have reported the association between the serotonin receptor family （5-HTR） gene polymorphisms and ADHD, but the results are still controversial. In this study, we conducted a meta-analysis of the association between 5-HTRIB, 5-HTR2A, and 5-HTR2C genetic variants and ADHD. The results showed that the 861G allele of 5-HTRIB SNP rs6296 could significantly increase the risk of ADHD （OR= 1.09, 95% CI： 1.01-1.18）; the 5-HTR2C gene rs518147 （OR=1.69, 95% CI： 1.38-2.07） and rs3813929 （OR = 1.57, 95% CI： 1.25-1.97） were all associated with the risk of ADHD. In addition, we also carried on a case- control study to explore the relevance between potential candidate genes 5-HTR1A, 5-HTRIE, 5-HTR3A and ADHD. The results indicated that 5-HTRIA rs6295 genotype （CC＋CG vs. GG OR=Z00, 95% CI： 1.23-3.27） and allele （OR=1.77, 95% CI： 1.16-2.72） models were statistically significantly different between case group and control group. This study is the first comprehensive exploration and summary of the association between serotonin receptor family genetic variations and ADHD, and it also provides more evidence for the etiology of ADHD.

关键词： attention deficit hyperactivity disorder serotonin receptor genetic variations meta-analysis association study

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attention deficit hyperactivity disorder and narcolepsy in childhood

Attention Deficit Hyperactivity Disorder and narcolepsy in c...

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中国睡眠研究会第九届学术年会

作者： QU Shan Xu Liyue Wang Peipei HanFang Peking University People’s Hospital

Objective:To explore theco-occurrence of narcolepsy and attention deficit hyperactivity disorder（ADHD）symptoms and compare the damage of cognitive function and improvement after treatment of Methylphenidate Hydrochloride for 8-16 weeks between narcolepsy with and without ***:278children narcolepsy patients（205 males and 73 females,with a range between 5andl7 years old） were selected from outpatients at the People’s Hospital,Peking University,from February2011 to July *** of them underwent polysomnography（PSG） followed by the multiple sleep latency test（MSLT）.Pediatric Sleep Questionnaire（PSQ）was *** patients were interviewed by a psychiatristusing DSM-IV diagnostic criteria from the Mini International Neuropsychiatric Interview for children and adolescents（MINI Kid）.Meanwhile,wecompared Psychological questionnaire between narcolepsy patients with and without ADHDusing inventory of subjective life quality（ISLQ）,the Depression Self-Rating Scale for Children（DSRS-C）,Screen for Child Anxiety Related Emotional disorders（SCARED）,Barrattlmpulsiveness Scale（BIS） and Behavior Rating Inventory of Executive Function—ParentsVersion（BRIEF-P）.Narcolepsy with ADHD symptoms were treated with 9-18 mg Methylphenidate Hydrochloride for 16 weeks and completed ADHD rating scale（ADHD-RS） and ***:Narcolepsy with ADHD symptoms was 28.8%（80/278）.Subtype:ADHD-1:95%（76/80）,ADHD-C:5%（4/80）,ADHD-H:0%（0/80）.Narcolepsy with ADHD symptoms had a statistically significant 3.611-fold increase in anxiety *** alsohad higher levels of impulsive symptoms and lower health-related quality of life,lower executive function（p＜0.05）.56 of 80（65%）got Methylphenidate Hydrochloride for 16 *** treatment,score of *** lower（13±2） than before（17±2）（t:7.951,p＜0.001） but no change before and after therapy in ADHDRS,ISLQ,DSRS-C,SCARED,BIS（P＞0.05）.Conclusion:ADHD is very common in children with *** with ADHD symptoms had higher levels of anxiety and im

关键词： attention deficit hyperactivity disorder narcolepsy methylphenidate treatment strategy co-occurrence

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Review of barriers and interventions to promote treatment engagement for pediatric attention deficit hyperactivity disorder care

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World Journal of Psychiatry 2021年第12期11卷 1206-1227页

作者： Raman Baweja Cesar A Soutullo James G Waxmonsky Department of Psychiatry and Behavioral Health Penn State College of MedicineHersheyPA 17033United States Louis A.Faillace MD Department of Psychiatry and Behavioral SciencesThe University of Texas Health Science Center at HoustonHoustonTX 77054United States

attention deficit hyperactivity disorder(ADHD)is a common and impairing behavioral health disorder,impacting over 5%of children *** are multiple evidence-based pharmacological and psychosocial treatments for ADHD,and greater service utilization is associated with improved acute and long-term ***,long-term outcomes are suboptimal as multimodal treatments are often not accessed and most care ends *** narrative review discusses barriers to engagement for children and adolescents with ADHD and their families as well as interventions to overcome these *** face a variety of structural and attitudinal barriers,ranging from cost and access to stigma and low self-efficacy to successfully implement *** are multiple interventions that may enhance engagement with ADHD care including psychoeducation,integration of behavioral services in general medical settings,telehealth as well as specific adaptations to existing ADHD treatments,such as the use of motivational interviewing or shared decision *** of behavioral health into general medical settings and telehealth have been found in controlled studies to increase access by reducing both structural and attitudinal *** motivational interviewing,shared decision making and other engagement interventions to evidence-based ADHD treatments has been found to reduce attitudinal barriers that translates into improved participation and satisfaction while enhancing ***,little is known about how to promote extended engagement with ADHD services even though a chronic care model for ADHD is recommended.

关键词： attention deficit hyperactivity disorder Treatment engagement Barriers Interventions Children Adolescents

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