Celastrus paniculatus oil ameliorates synaptic plasticity in a rat model of attention deficit hyperactivity disorder
作者机构：Zydus Research CentreCadila Healthcare Ltd.AhmedabadGujaratIndia Department of PharmacologyInstitute of PharmacyNirma UniversityAhmedabadGujaratIndia
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2021年第11卷第3期
页 面：105-114页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Attention deficit hyperactivity disorder Celastrus paniculatus Biogenic amines Synaptophysin Nerve growth factor
摘 要：Objective:To explore the effect and mechanism of action of Celastrus paniculatus oil on the treatment of perinatal rats with attention deficit hyperactivity ***:In the perinatal stage,the rats were either isolated or administered with lead acetate to establish an animal model of attention deficit hyperactivity *** served as the reference ***’behaviours were assessed through Y-maze,novel object preference,fear conditioning and residentintruder aggression *** stress parameters,bioamine concentration(dopamine,noradrenaline and 5-hydroxytryptamine),nerve growth factor,interleukin-6,nuclear factor-κB,and tumour necrosis factor(TNF)-αwere *** immunohistochemical assay was ***:Celastrus paniculatus oil significantly improved behavioural parameters in Y maze,novel object preference,discrimination index,fear conditioning and resident intruder aggressive *** treatment groups showed a decrease in malondialdehyde *** in the levels of dopamine,noradrenaline,and serotonin were restored by Celastrus paniculatus *** paniculatus oil increased nerve growth factor and decreased interleukin-6,nuclear factor-κB,and TNF-α.Synaptophysin immunoreactivity was also improved by Celastrus paniculatus oil with alleviated reactive gliosis,degeneration,and vascular ***:This research shows the therapeutic potential of Celastrus paniculatus oil for the treatment of attention deficit hyperactivity disorder.
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