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Evaluation of G3BP1 in the prognosis of acute and acute-on-chronic liver failure after the treatment of artificial liver support system

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World Journal of Hepatology 2024年第2期16卷 251-263页

作者： Wen-Yuan Li Lu-Wen Wang Jin Dong Yao Wang Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Nephrology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND The increased expression of G3BP1 was positively correlated with the prognosis of liver *** To investigate the effect of G3BP1 on the prognosis of acute liver failure(ALF)and acute-on-chronic liver failure(ACLF)after the treatment of artificial liver support system(ALSS).METHODS A total of 244 patients with ALF and ACLF were enrolled in this *** levels of G3BP1 on admission and at discharge were *** validation set of 514 patients was collected to verify the predicted effect of G3BP1 and the viability of *** This study was shown that lactate dehydrogenase(LDH),alpha-fetoprotein(AFP)and prothrombin time were closely related to the prognosis of *** the ALSS treatment,the patient’amount of decreased G3BP1 index in difference of G3BP1 between the value of discharge and admission(difG3BP1)liver disease high-risk or low-risk *** the same time,compared with the inflam matory marks[tumor necrosis factor-α,interleukin(IL)-1βand IL-18],G3BP1 had higher discrimination and was more stable in the model analysis and validation *** combined with AFP and LDH,concordance index was respectively 0.84 and 0.8 in training and validation *** This study indicated that G3BP1 could predict the prognosis of ALF or ACLF patients treated with *** combination of G3BP1,AFP and LDH could accurately evaluate the disease condition and predict the clinical endpoint of patients.

关键词： G3BP1 Prognosis Acute liver failure Acute-on-chronic liver failure artificial liver support system

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Nursing Care of 10 Patients with Vasovagal Reflex Caused by artificial liver support system Treatment

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Open Journal of Nursing 2024年第5期14卷 177-182页

作者： Yingying Zhang The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China

This study outlines the essential nursing strategies employed in the care of 10 patients experiencing vascular vagal reflex, managed with artificial liver support systems. It highlights a holistic nursing approach tailored to the distinct clinical manifestations of these patients. Key interventions included early detection of psychological issues prior to initiating treatment, the implementation of comprehensive health education, meticulous monitoring of vital signs throughout the therapy, prompt emergency interventions when needed, adherence to prescribed medication protocols, and careful post-treatment observations including venous catheter management. Following rigorous treatment and dedicated nursing care, 7 patients demonstrated significant improvement and were subsequently discharged.

关键词： Vasovagal Reflex artificial liver support system Nursing Care

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Establishment of a risk assessment score for deep vein thrombosis after artificial liver support system treatment

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World Journal of Clinical Cases 2021年第31期9卷 9406-9416页

作者： Yun Ye Xiang Li Li Zhu Cong Yang You-Wen Tan Department of Hepatology The Third Hospital of Zhenjiang Affiliated Jiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND The artificial liver support system(ALSS)is an effective treatment method for liver failure,but it requires deep venous intubation and long-term indwelling ***,the coagulation mechanism disorder of basic liver failure diseases,and deep venous thrombosis(DVT)often *** To evaluate the risk factors for DVT following use of an ALSS and establish a risk assessment *** This study was divided into three *** the first stage,the risk factors for DVT were screened and the patient data were collected,including ALSS treatment information;biochemical indices;coagulation and hematology indices;complications;procoagulant use therapy status;and a total of 24 *** the second stage,a risk assessment score for DVT after ALSS treatment was *** the third stage,the DVT risk assessment score was *** A total of 232 patients with liver failure treated with ALSS were enrolled in the first stage,including 12 with lower limb *** regression analysis showed that age[odds ratio(OR),1.734;P=0.01],successful catheterization time(OR,1.667;P=0.005),activity status(strict bed rest)(OR,3.049;P=0.005),and D-dimer level(≥500 ng/mL)(OR,5.532;Psystem for risk *** the validation group,a total of 213 patients with liver failure were treated with ALSS,including 14 with lower limb *** the cutoff value of risk assessment was 3,the specificity and sensitivity of the risk assessment score were 88.9%and 85.7%,*** A simple risk assessment scoring system was established for DVT patients with liver failure treated with ALSS and was verified to have good sensitivity and specificity.

关键词： artificial liver support system Deep vein thrombosis liver failure Risk factors Thrombosis

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Treatment of fatal hepatitis in the intermediate and advanced stages by artificial liver support system with continuous hemodialysis and filtration

Treatment of fatal hepatitis in the intermediate and advance...

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第一届全国人工肝及血液净化学术年会暨全国人工肝及血液净...

作者： He Jinqiu Che DaPing Liu Yan Chen Jiangqing Zhang QiYong Den jianTing Lu DingYing. Nanchang Ninth People’s Hospital,Jiangxi,Nanchang 330032,China

Objective To find the clinical effects of artificial liver support system (ALSS) with continuous hemodialysis and filtration (CHDF) on the treatment of fatal hcpatitis in the intermediate and advanced stages and observe if hepatic encephalopathy,hepatorenal syndrome and function of cleating the cellular factor have been *** To treat 33 cases of fatal hepatitis in the intermediate and advanced stages 96 times,and 2.9 times averagely in the treatment group by the way of ALSS and CHDF,and compare the clinical manifestation,degree of hepatic encephalopath,restoration of renal function and levers of TBIL、NH、 PT、PTa,、BUN、Cr、electrolytic tension,TNF-α、IL-6 and LSP prior to and subsequent to the *** contrast group consists of 36 cases of similar patients who were abmitted to the hospital during the same period of *** 63.64% at survival rate and 27.27% at case fatality rate in the treatment group,but 36.11% and 52.78% (P<0.01) respectively in the contrast group:81.08% at revival rate for hepatic encephalopathy.9 out of 13 cases of hepatorenal syndrome have restored the renal function,but 2 out of 14 cases of hepatorenal syndrome have restored renal function in the contrast group;TBIL,NH,BUN and Cr have been obviously reduced,the electrolyte disorder has been rectified,and TNF-α.*** have been redrced respectively to (53.60±14.27)pg/ml (P<0.01),(39.48±13.15)pg/ml (P<0.01)and (1.33±0.41)Eu/ml (P<0.05) from (18.14±22.65) pg/ml,(66.67±18.37) pg/ml,(3.81±0.62) Eu/ml afterthe *** 21 patients who have received the treatment of plasma exchange with CHDF (64 times),there are 5 cases (12.5%) of plasma allergy,and among 9 patients who have received the treatment of plasma absorption with CHDF and blood perfusion with (25 times),There are 2 cases of thrombocytopenia 5 *** the operation,there are 6 cases of capillary hemorrhage (9 times) in the region of *** 1 case of rupture of right kidney in the therapeutic process o

关键词： Fatal hepatitis in the intermediate and advanced stages artificial liver support system Continuous hemodialysis and filtration Hepatic encephalopathy Hepatorenal syndrome Cellular factor.

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Progress in hepatitis B virus-related acute-on-chronic liver failure treatment in China:A large,multicenter,retrospective cohort study using a propensity score matching analysis

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 535-541页

作者： Lan-Lan Xiao Xiao-Xin Wu Jia-Jia Chen Dong Yan Dong-Yan Shi Jian-Rong Huang Xiao-Wei Xu Lan-Juan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang UniversityHangzhou 310003China

Background:Hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF)has a high short-term ***,the treatment progression for HBV-ACLF in China in the past decade has not been well *** present study aimed to determine whether the HBV-ACLF treatment has significantly improved during the past ***:This study retrospectively compared short-term(28/56 days)survival rates of two different nationwide cohorts(cohort I:2008-2011 and cohort II:2012-2015).Eligible HBV-ACLF patients were enrolled *** in the cohorts I and II were assigned either to the standard medical therapy(SMT)group(cohort I-SMT,cohort II-SMT)or artificial liver support system(ALSS)group(cohort IALSS,cohort II-ALSS).Propensity score matching analysis was conducted to eliminate baseline differences,and multivariate logistic regression analysis was used to explore the independent factors for 28-day ***:Short-term(28/56 days)survival rates were significantly higher in the ALSS group than those in the SMT group(P<0.05)and were higher in the cohort II than those in the cohort I(P<0.001).After propensity score matching,short-term(28/56 days)survival rates were higher in the cohort II than those in the cohort I for both SMT(60.7%vs.53.0%,50.0%vs.39.8%,P<0.05)and ALSS(66.1%vs.56.5%,53.0%vs.44.4%,P<0.05)*** 28-day survival rate was higher in patients treated with nucleos(t)ide analogs than in patients without such treatments(P=0.046).Multivariate logistic regression analysis revealed that ALSS(OR=0.962,95%CI:0.951-0.973,P=0.038),nucleos(t)ide analogs(OR=0.927,95%CI:0.871-0.983,P=0.046),old age(OR=1.028,95%CI:1.015-1.041,P<0.001),total bilirubin(OR=1.002,95%CI:1.001-1.003,P=0.004),INR(OR=1.569,95%CI:1.044-2.358,P<0.001),COSSH-ACLF grade(OR=2.683,95%CI:1.792-4.017,P<0.001),and albumin(OR=0.952,95%CI:0.924-0.982,P=0.002)were independent factors for 28-day ***:The treatment for patients with HBV-ACLF has improved

关键词： Hepatitis B virus-related acute-on-chronic liver failure Propensity score matching analysis Short-term survival rate Standard medical therapy artificial liver support system

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