Evaluation of G3BP1 in the prognosis of acute and acute-on-chronic liver failure after the treatment of artificial liver support system
作者机构：Department of AnesthesiologyRenmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Infectious DiseasesRenmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of NephrologyRenmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2024年第16卷第2期
页 面：251-263页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：National Natural Science Foundation of China [82100630, 82100894] Beijing iGandan Foundation [iGandanF-1082022-RGG031]
主 题：G3BP1 Prognosis Acute liver failure Acute-on-chronic liver failure Artificial liver support system
摘 要：BACKGROUND The increased expression of G3BP1 was positively correlated with the prognosis of liver *** To investigate the effect of G3BP1 on the prognosis of acute liver failure(ALF)and acute-on-chronic liver failure(ACLF)after the treatment of artificial liver support system(ALSS).METHODS A total of 244 patients with ALF and ACLF were enrolled in this *** levels of G3BP1 on admission and at discharge were *** validation set of 514 patients was collected to verify the predicted effect of G3BP1 and the viability of *** This study was shown that lactate dehydrogenase(LDH),alpha-fetoprotein(AFP)and prothrombin time were closely related to the prognosis of *** the ALSS treatment,the patient’amount of decreased G3BP1 index in difference of G3BP1 between the value of discharge and admission(difG3BP1)0 group had a nearly 10-fold increased risk of progression compared with the amount of increased G3BP1 *** subgroup analysis showed that the difG3BP10 group had a higher risk of progression,regardless of model for end-stage liver disease high-risk or low-risk *** the same time,compared with the inflam matory marks[tumor necrosis factor-α,interleukin(IL)-1βand IL-18],G3BP1 had higher discrimination and was more stable in the model analysis and validation *** combined with AFP and LDH,concordance index was respectively 0.84 and 0.8 in training and validation *** This study indicated that G3BP1 could predict the prognosis of ALF or ACLF patients treated with *** combination of G3BP1,AFP and LDH could accurately evaluate the disease condition and predict the clinical endpoint of patients.
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