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Effects of Zhibitai capsules on blood lipids and arterial elasticity

中国现代医学杂志 2011年第3期21卷 330-335页

作者： Sheng-ying Jia Quan-yue Huang Department of Cardiology the Second Xiangya Hospital Central South University Changsha Hunan 410011P.R.China

Objective To evaluate the effects of Zhibitai(ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular *** Eighty three subjects with high risk factors of cardiovascular diseases were enrolled into the study and randomized to two groups,i.e.,the ZBT group(n =44,treated with ZBT 0.48 g twice per day) and the atorvastatin(ATO) group(n =39,treated with ATO 10 mg per day).The levels of fasting serum lipids including total cholesterol(TC),triglyceride(TG),high and low density lipoprotein cholesterol(HDL-C and LDL-C) and pulse wave velocity(PWV) were investigated before and eight weeks after *** The serum levels of TG,TC,LDL-C,femoral-ankle PWV(FAPWV) and carotid-radial PWV(CRPWV) were markedly decreased after the therapy with ZBT or ATO for 8 weeks(P 0.05) after eight-week's *** ZBT could reduce the levels of FAPWV and CRPWV,thus improve the elasticity of medium-sized peripheral muscular arteries in addition to its lipids lowering *** efficacy of ZBT is similar to that of ATO.

关键词： Zhibitai capsule atorvastatin blood lipid arterial elasticity pulse wave velocity

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Microalbuminuria associated with systolic blood pressure and arterial compliance in Chinese metabolic syndrome patients

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Chinese Medical Journal 2007年第16期120卷 1395-1399页

作者： LI Xin-li XU Qiong LU Xin-zheng ZHANG Hai-feng ZHOU Yan-li CAO Ke-jiang HUANG Jun Department of Cardiology First Aftiliated Hospital of Nanjing Medical University Nanjing 210029 China

Background There is significant evidence showing that microalbuminuria and arterial compliance are sensitive markers for early cardiovascular diseases. However, whether microalbuminuria is associated with reduced arterial compliance in Chinese metabolic syndrome （MS） patients remains unknown. Methods According to the definition of MS proposed by ATPⅢ in 2001, USA, subjects （n=362） were divided into three groups according to the number of risk factors： group 1 （control）, group 2 （medium, 〈 3 risk factors） and group 3 （MS, ≥ 3 risk factors）. Both large artery compliance （C1） and small artery compliance （C2） were measured with the CVProfilor DO-2020 Cardiovascular Profiling System, and microalbuminuria was evaluated with the ratio of albumin to urine creatinine. Results （1） As C1 and C2 levels elasticity decreased, albumin creatinine ratio （ACR） and the prevalence of microalbuminuria increased within those groups with MS risk factors. C1 and C2 were negatively correlated with the ranking of MS risk factors, ACR was positively correlated with the ranking of MS risk factors （all P〈0.05）. （2） Subjects were also categorized into a microalbuminuria group and a normal group, C1 and C2 in the microalbuminuria group were lower than in the normal group. （3） Multivariate regression analysis showed that increased systolic blood pressure （SBP） and reduced arterial compliance were the main risk factors for microalbuminuria in the MS group. Conclusions The risk of developing microalbuminuria was higher in the subjects with multiple metabolic abnormalities. Increased systolic blood pressure and reduced arterial compliance may be the main predictors for microalbuminuria in MS.

关键词： metabolic syndrome microalbuminuria arterial elasticity

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Effect of hormone therapy on carotid elasticity in postmenopausalwomen by Echo-tracking technique

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South China Journal of Cardiology 2011年第1期12卷 20-26,39页

作者： YANG Jin-ru LI Fen JIANG Jue Department of Ultrasonics The First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 710061 China Maternal and Child Health Center The First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 710061 China Department of Ultrasonics The Second Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 710003 China

Background Studies showed that arterial elasticity changes appear earlier than any structural changes, therefore, its accurate evaluation could be applied at early stage to prevent disease. Echo-tracking（E-tracking） technique can track the wall motion trajectory in real-time, calculate the change in vascular diameter automatically, and assessment of vascular stiffness and flexibility directly. This article aims to assess the change of elasticity of carotid artery after hormone therapy （HT） using Echo-tracking technology. Methods Echotracking was used to evaluate the carotid elastic moduli, such as the pressure-strain elastic modulus （Ep）, stiffness parameter （β）, arterial compliance （AC）, pulse wave conducting velocity （PWVβ） and augmentation index （AI） by Aloka α10 color Doppler ultrasound diagnosis system. Results Ep,β and PWVβ in HT group were significantly lower than those in the control group （P 〈 0.01）, while AC was obviously higher than the control group （P 〈 0.01）. E2 was negatively related to β, Ep and PWVβ （r = -0.607, r = -0.573, r = -0.574, P 〈 0.001）, while positively related to AC （r = 0.574, P 〈 0.001）; endothelial-dependent dilatation （EDD） was negatively related to β, Ep and PWVβ （r = -0.521, r = -0.411, r = -0.456, P 〈 0.001）, while positively related to AC （r = 0.443, P 〈 0.001）; But IMT was positively related to β, Ep and PWVβ（r = 0.553, r = 0.444, r = 0.529, P 〈 0.001）, while negatively related to AC （r = -0.400, P 〈 0.001）. Conclusions arterial stiffness increases and compliance decreases in menopausal women. As EDD decreases arterial elasticity recedes, and HT can improve arterial elasticity. E-tracking technology can discover the early changes in arterial stiffness effectively and it is more sensitive in finding out the changes of stiffness in early atherosclerosis than IMT of carotid artery.

关键词： echo-tracking technique hormone therapy menopause arterial elasticity

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Insulin resistance is associated with subclinical vascular disease in humans

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World Journal of Diabetes 2019年第2期10卷 63-77页

作者： María M Adeva-Andany Eva Ameneiros-Rodríguez Carlos Fernández-Fernández Alberto Domínguez-Montero Raquel Funcasta-Calderón Internal Medicine Department Hospital General Juan Cardona

Insulin resistance is associated with subclinical vascular disease that is not justified by conventional cardiovascular risk factors,such as smoking or *** injury associated to insulin resistance involves functional and structural damage to the arterial wall that includes impaired vasodilation in response to chemical mediators,reduced distensibility of the arterial wall(arterial stiffness),vascular calcification,and increased thickness of the arterial *** dysfunction associated to insulin resistance is present in asymptomatic subjects and predisposes to cardiovascular diseases,such as heart failure,ischemic heart disease,stroke,and peripheral vascular *** and functional vascular disease associated to insulin resistance is highly predictive of cardiovascular morbidity and *** pathogenic mechanisms remain *** studies have demonstrated that animal protein consumption increases the risk of developing cardiovascular disease and predisposes to type 2 diabetes(T2D)whereas vegetable protein intake has the opposite *** disease linked to insulin resistance begins to occur early in *** and adolescents with insulin resistance show an injured arterial system compared with youth free of insulin resistance,suggesting that insulin resistance plays a crucial role in the development of initial vascular *** of the vascular dysfunction related to insulin resistance should begin early in *** the clinical onset of T2D,asymptomatic subjects endure a long period of time characterized by insulin *** vascular dysfunction begins to develop during this phase,so that patients with T2D are at increased cardiovascular risk long before the diagnosis of the disease.

关键词： Diabetes Cardiovascular risk arterial stiffness arterial elasticity Intimamedia thickness Vascular calcification Insulin resistance Animal protein Vegetable protein

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Local Pulse Wave Velocity Estimation in the Carotids Using Dynamic MR Sequences

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Journal of Biomedical Science and Engineering 2015年第4期8卷 227-236页

作者： Mohamad Ayham Darwich Francois Langevin Khaldoun Darwich Faculty of Technical Engineering Tartus UniversityTartusSyria Advanced Medical Imaging Center University of Technology of CompiègneCompiègneFrance Faculty of Dentistry Damascus UniversityDamascusSyria

The current study presents a new protocol for local pulse wave velocity (PWV) measurement using dynamic MR sequences, which have a high temporal resolution (TR < 6 ms). MR images were obtained at two positions along the common carotid artery, separated by a distance of 5 cm. In each phase of a MR series, carotid region was automatically extracted and then its area distension waveform could be obtained. Sixteen volunteers with no symptoms of cardiovascular diseases were studied. For local PWV estimation, three delay estimation principles were tested and produced the following values: intersecting tangents method (M1): 4.72 ± 1.40 m/s, second derivative method (M2): 4.94 ± 1.68 m/s and cross-correlation method (M3): 5.03 ± 1.17 m/s. The cross-correlation method showed a relative high reliability as its least standard deviation.

关键词： Local Pulse Wave Velocity arterial elasticity Dynamic Magnetic Resonance Imaging

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