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The role of cell cycle control correlative gene protein in arsenism caused by burning coal contain arsenic

The role of cell cycle control correlative gene protein in a...

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贵州省环境诱变剂学会第二届学术交流会

作者： Hong Feng~#,Aihua Zhang~#,Xiaoxin Huang~+,Xuexin Dong~+ # Department of Prevention Medicine,Guiyang Medical College,Guiyang,550004,China. + The 44~(th) hospital of PLA,Guiyang,550009,China.

arsenism has been all over the world and also become one of the urgent public health *** an animal model for the carcinogenicity of arsenic has never been developed,its mechanism related to chronic poisoning and especially to carcinoma is not *** purpose of this study was to study the mechanisms of arsenism especially resulting in skin carcinoma caused by burning coal contain arsenic.70 skin samples from arsenism patients caused by burning coal contain arsenic were included and according to the pathological diagnosis,they were divided into carcinoma grou(A group),Precancerous lesions group(B group),hyperkeratosis group(C group) and general pathological changes group(D group).The expressions of cell cycle control correlative gene P16、P21 and cyclinDl proteins in skins from arsenism patient were detected by immunohistochemistry *** the increasing pathologic change in skin,the positive cell density and percentage of P16 were gradually decreased,but these of P21 and cyclinD1 were gradually *** of P16 protein in A,B and C groups were lower than D and the control groups(Parsenism and skin hyperkeratosis may be earlier stage of *** monitoring of expressions of P16、P21 and cyclinD1 proteins may be useful for early detecting and treatment and prognostic judgment of skin carcinoma caused by arsenic.

关键词： arsenism P16 P21 CyclinD1 Skin with pathological signs

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A case-control study on relationship between arsenic in drinking water and skin lesions in endemic arsenism area of Shanxi province,China

A case-control study on relationship between arsenic in drin...

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中国毒理学会第五次全国学术大会

作者： Endo Yoko Endo Ginji Yamanaka Kenzo Research Center for Occupational Poisoning Tokyo Rosai HospitalTokyo 143-0013 Japan Osaka City University Medical School 545-8585 Osaka Nihon University College of Pharmacy 275-8555 Funabasgi Japan

＜正＞Chronic arsenic exposure in human is associated with symptoms of skin lesions,including of hyperpigmentation （melanosis）,hypopigmentation,keratosis,hyperkeratosis skin ulceration,and skin cancers（Bowen’s disease）.The evidence of epidemiologic data was not *** the current research, the relationship between arsenic in drinking water and skin lesions in endemic arsenism area of Shanxi province was carried out in China.203 cases and 120 controls were selected in 19 endemic arsenism villages in Shanxi *** content of arsenic in drinking water which was collected indoors was half-quantitatively screened by kit made by Chinese Center for Disease Control and Prevention,then quantitatively determined by HPLC-ICP-MS *** of endemic arsenism were diagnosed by the standard of diagnosis for endemic *** analysis was carried out using SAS software（version 9.13,SAS institute,Inc.,Cary,NC,USA）.There are 64.2%samples above the arsenic level（50μg/L）of national drinking water and the median value of arsenic in drinking water is 96.3μg/L in 201 water *** OR（95%CI）value between arsenic in drinking water and hyperkeratosis,hyperpigmentation,depigmentation and skin lesions is 1.908（1.442-2.524）,2.058（1. 460-2.900）,3.086（2.316-4.112）,3.142（2.434-4.056）, *** values of OR are statistically *** the increasing of arsenic in drinking water,the prevalence of skin lesions（p＜0.05） and the degree of skin lesions increased （p＜0.05）.There is positive dose-response relationship between arsenic in drinking water and skin *** is a medial arsenic pollution *** current epidemiological research showed the high concentration of iron in drinking water enhanced the arsenic-related skin lesions,especially when the concentration of arsenic in drinking water is lower than 50μg/L.

关键词： arsenism Skin lesions Case-control study

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