The role of cell cycle control correlative gene protein in arsenism caused by burning coal contain arsenic
会议名称：《贵州省环境诱变剂学会第二届学术交流会》
会议日期：2005年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by Natural Sciences Fund Committee of China grant No.30060077/C030108 grant No.D97-3 from the Natural Sciences Fund Committee of Guizhou province,China
关 键 词：Arsenism P16 P21 CyclinD1 Skin with pathological signs
摘 要：Arsenism has been all over the world and also become one of the urgent public health *** an animal model for the carcinogenicity of arsenic has never been developed,its mechanism related to chronic poisoning and especially to carcinoma is not *** purpose of this study was to study the mechanisms of arsenism especially resulting in skin carcinoma caused by burning coal contain arsenic.70 skin samples from arsenism patients caused by burning coal contain arsenic were included and according to the pathological diagnosis,they were divided into carcinoma grou(A group),Precancerous lesions group(B group),hyperkeratosis group(C group) and general pathological changes group(D group).The expressions of cell cycle control correlative gene P16、P21 and cyclinDl proteins in skins from arsenism patient were detected by immunohistochemistry *** the increasing pathologic change in skin,the positive cell density and percentage of P16 were gradually decreased,but these of P21 and cyclinD1 were gradually *** of P16 protein in A,B and C groups were lower than D and the control groups(P0.05,P0.01).Expressions of P21 protein in all pathological groups were higher than the control(P0.05,P0.01),expressions of cyclinD1 protein in A、B and C groups were higher the D group and the control(P0.05,P0.01).There was significance correlativity between gene protein and urinary arsenic concentrations,(P0.01).It is negative correlativity between P16 and urinary *** P21,cyclinD1 and urinary arsenic are positive *** has been demonstrated that P16、P21 and cyclinD1 may related to cause skin carcinoma and may play a significant role in the development of arsenism and skin hyperkeratosis may be earlier stage of *** monitoring of expressions of P16、P21 and cyclinD1 proteins may be useful for early detecting and treatment and prognostic judgment of skin carcinoma caused by arsenic.