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Study on Intervention of Blood Sugar and Blood Lipid in Diabetic Mice by Abrus Cantoniensis and armeniaca mume sieb and Their Compatibility

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TMR Pharmacology Research 2021年第4期1卷 13-19页

作者： Yixin Zhang Shibo Zhao Sitong Lu Danni Lu Yedong Shen Changhuan He Zhonggang Wu Suoyi Huang College of Clinical Medicine Youjiang Medical University for NationalitiesBaiseChina Key Laboratory of Guangxi Universities on National Medicine in Youjiang River BaiseChina

Objective:The study aims to explore the interventional effect of Abrus cantonensis and armeniaca mume sieb and their compatibility on blood glucose and blood lipid in diabetic mice and to explore the optimal ratio of efficacy of their ***:SPF Kunming male mice were fed with high sugar and high fat diet for 6 weeks and then intraperitoneally injected with STZ solution to establish a diabetes *** successfully modeled mice were randomly divided into 6 groups according to their body weight:model group,Abrus Cantoniensis group,armeniaca mume sieb group,as well as Abrus Cantoniensis and armeniaca mume sieb group divided into 1:2,1:1 and 2:1 groups according to volume ratio with 10 mice in each *** 10 healthy mice were taken as blank group and intraperitoneally injected with sodium citrate *** corresponding solution was given intragastric administration by body mass once a day for 20 *** the last administration,fasting was performed for 12 *** was collected by the method of eyeball blood collection to determine the contents of fasting blood glucose,total cholesterol Triacylglycerol,triglyceride,low density lipoprotein and high-density ***:Compared with Abrus Cantoniensis and armeniaca mume sieb groups,Glu,TG,TC and LDL-C of the three compatibility groups significantly decreased,with the most significant decrease in the compatibility group 1:2,while there was no significant difference in HDL-C among all ***:Abrus Cantoniensis and armeniaca mume sieb and their combination have synergistic effects on the improvement of blood glucose and lipid levels in mice with high glucose and high fat combined with STZ-induced diabetes mellitus *** all the experimental groups,the compatibility 1:2 group had the best effect.

关键词： Abrus Cantoniensis armeniaca mume sieb compatibility diabetes mellitus blood sugar blood lipid

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