Study on Intervention of Blood Sugar and Blood Lipid in Diabetic Mice by Abrus Cantoniensis and Armeniaca mume Sieb and Their Compatibility

作     者：Yixin Zhang Shibo Zhao Sitong Lu Danni Lu Yedong Shen Changhuan He Zhonggang Wu Suoyi Huang 

作者机构：College of Clinical MedicineYoujiang Medical University for NationalitiesBaiseChina Key Laboratory of Guangxi Universities on National Medicine in Youjiang RiverBaiseChina 

出 版 物：《TMR Pharmacology Research》 (TMR药理学研究)

年 卷 期：2021年第1卷第4期

页      面：13-19页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by National Natural Science Foundation of China(No.81360684) Guangxi Key Research and Development Plan Project(Gui Ke AB18221095) Teaching Teacher Training Project from Youjiang Medical University for Nationalities-National Teaching Teacher Training Project(You Hospital ZiNo.98) High-level Talent Research Projects from Youjiang Medical University For Nationalities(No.01002018079) China National and Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599022) China Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599073) 

主　　题：Abrus Cantoniensis Armeniaca mume Sieb compatibility diabetes mellitus blood sugar blood lipid 

摘      要：Objective:The study aims to explore the interventional effect of Abrus cantonensis and Armeniaca mume Sieb and their compatibility on blood glucose and blood lipid in diabetic mice and to explore the optimal ratio of efficacy of their ***:SPF Kunming male mice were fed with high sugar and high fat diet for 6 weeks and then intraperitoneally injected with STZ solution to establish a diabetes *** successfully modeled mice were randomly divided into 6 groups according to their body weight:model group,Abrus Cantoniensis group,Armeniaca mume Sieb group,as well as Abrus Cantoniensis and Armeniaca mume Sieb group divided into 1:2,1:1 and 2:1 groups according to volume ratio with 10 mice in each *** 10 healthy mice were taken as blank group and intraperitoneally injected with sodium citrate *** corresponding solution was given intragastric administration by body mass once a day for 20 *** the last administration,fasting was performed for 12 *** was collected by the method of eyeball blood collection to determine the contents of fasting blood glucose,total cholesterol Triacylglycerol,triglyceride,low density lipoprotein and high-density ***:Compared with Abrus Cantoniensis and Armeniaca mume Sieb groups,Glu,TG,TC and LDL-C of the three compatibility groups significantly decreased,with the most significant decrease in the compatibility group 1:2,while there was no significant difference in HDL-C among all ***:Abrus Cantoniensis and Armeniaca mume Sieb and their combination have synergistic effects on the improvement of blood glucose and lipid levels in mice with high glucose and high fat combined with STZ-induced diabetes mellitus *** all the experimental groups,the compatibility 1:2 group had the best effect.