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Journal of Traditional Chinese Medicine 2016年第2期36卷 160-164页

作者： Siavash Vaziri Mahdi Mojarrab Mohammad Hosein Farzaei Farid Najafi Ali Ghobadi Department of Infectious Disease Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah *** Iran Pharmaceutical Sciences Research Center Kermanshah University of Medical Sciences Kermanshah *** Iran Pharmaceutical Sciences Research Center Kermanshah University of Medical SciencesKermanshah *** Iran Kermanshah University of Medical Sciences Kermanshah *** Iran Department of Traditional Pharmacy School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran

OBJECTIVE: To determine the effects of decoction derived from the leaves of Nicotiana tabacum(L.)as a mouthwash on minor recurrent ***: A randomized double-blinded placebo-controlled clinical trial was conducted on 60 patients with minor recurrent aphthous. Treatment comprised of application of tobacco or placebo mouthwash(10 m L 3 times a day) for 5 days. Clinical evaluation included pain level using a visual analog scale and ulcer size on days 1, 3, and 5 were measured. Adverse effects after mouthwash application were recorded, and the oral mucosa was examined by the investigator at each ***: A total of 54 subjects with the mean age(38 ± 10) years fulfilled the study. No minor and major adverse effects were observed. In the treatment group, ulcer pain score was decreased by 79.2%and 93.8% and ulcer size was reduced by 69.1%and 92.2%(days 3 and 5, respectively), which was significantly greater than the control group(P aphthous.

关键词： Stomatitis aphthous Tobacco Pain Ul cer Medicine Traditional Complementary thera pies Mouthwashes

Effects of Zingiber officinalis (WILLD.)*** on minor recurrent aphthous stomatitis: a randomized pragmatic trial

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Journal of Traditional Chinese Medical Sciences 2018年第1期5卷 58-63页

作者： Qian Du Shenglou Ni Lin Guo Wenjie Song Kun Zhao Ni Liu Xinrong Wang Xun Ma Yanling Fu Quanming Tan Beijing University of Chinese Medicine Beijing 100029China Singapore Thong Chai Medical Institution Thong Chai Building 169874Singapore

Objective:To evaluate the effects of dried ginger rhizome (DGR;Zingiber officinalis (WILLD.) ROSC.),prepared as a membrane,in minor recurrent aphthous stomatitis (miRAS)treatment and explore its mechanism of action by detecting changes in levels of epidermal growth factor (EGF) and tumor necrosis factor (TNF)-α in ***:Fifty-nine miRAS patients were enrolled in this *** number of participants in the dried ginger rhizome membrane (DGRM) group was 30,and 29 were in the placebo membrane (PM) *** sealed envelopes containing either type of membrane were coded *** and participants were blinded to group assignments.A visual analog scale (VAS) was used for pain,follow-up information for healing time,and enzyme-linked immunosorbent assays to measure the concentrations of EGF and TNF-α.Results:In terms of VAS,there was a significant difference between pre-and post-DGRM treatment (P .05).A significant difference was observed in the healing time between the two groups (6.08 (2.712) vs.8.04 (2.142) days).The mean healing time in the DGRM group was shorter than that in the PM group (P <.05).In both groups,the salivary EGF concentration decreased significantly after treatment (P <.05),but the mean level in the DGRM group was significantly lower than that in the PM group (P <.05).The mean TNF-α level in both groups was increased significantly after treatment (P <.05),but patients who used DGRMs had a significantly lower level than that in the PM group (P <.05).Conclusion:The present study provides evidence that DGRMs are effective treatment for *** ginger rhizome has obvious effects on pain relief,shortening of healing time,reducing the EGF level in saliva,and has an inhibitory effect on TNF-α release.

关键词： Dried ginger rhizome membrane Recurrent aphthous stomatitis Epidermal growth factor Tumor necrosis factor-α

Evaluation of a Newly Developed Laser Pen as a Home Care Device for Pain Reduction of Recurrent aphthous Stomatitis (Preliminary Study)

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International Journal of Clinical Medicine 2015年第1期6卷 19-25页

作者： Maziar Mir Seyed Masoud Mojahedi Hassan Adalatkhah Jan Tunér Amir Mansour Shirani Roshan Babaalipour Masoud Shabani Conservative Dentistry RWTH International Academy Aachen Germany Deputy for Research Ardebil University of Medical Sciences Ardebil Iran Private Dental Clinic Gr&aumlngesberg Sweden Oral Medicine Department Dental School of Islamic Azad University Khorasgan Iran Science Department Islamic Azad University Ardebil Iran

Objective: The aim of this survey is to evaluate the effect of a new developed laser pen as a home care device for patients’ pain reduction with recurrent aphthous stomatitis. Background data: Recurrent aphthous stomatitis (RAS) is one of the most common and painful ulcers in the oral cavity. Low Level Laser Therapy (LLLT) has been used successfully for reducing pain and healing time in comparison with corticosteroids and placebo in some studies. But these treatments are done in the clinics and it seems that there is no report of the laser treatment as a home care device up to this study. Methods: This was a prospective, randomized trial pilot study. Thirty patients with RAS were divided into three similar groups. The group one (n = 10) was treated with a diode laser, 660 nm, 40 mw, continuous wave, 1.2 J, 6 J/cm2, for five consecutive days (twice per day, 30 seconds each session). The second group (n = 10) was treated with a topical triamcinolone (adcortyl in orabase) ointment four times per day and the third group (n = 10) was treated with placebo (red light pen) the same way as Group 1. All the patients were evaluated with a Visual Analogue Scale (VAS) before and after treatment on the consecutive days. The data was analysed by one way ANOVA and PostHoc tests. Results: The results show that the laser pen and triamcinolon in orabase ointment have similar results and both have better results than placebo in the control of the recurrent aphthous stomatitis pain (p value: 0.001). Conclusion: In this clinical pilot study the laser pen as a home care device seems to be useful for the treatment of RAS.

关键词： Low Level Laser Therapy Recurrent aphthous Stomatitis Pain Corticosteroid

Therapeutic Role of Isotretinoin in the Management of Recurrent aphthous Stomatitis (Single-Blind Controlled Therapeutic Study)

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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第1期5卷 15-21页

作者： Khalifa E. Sharquie Raad M. Helmi Adil A. Noaimi Mohand A. A. Kadhom Raafa K. Al-Hayani Scientific Council of Dermatology and Venereology-Iraqi and Arab Board for Medical Specializations Department of Dermatology and Venereology College of Medicine University of Baghdad Baghdad Iraq Department of Oral Medicine College of Dentistry Al-Mustansiriya University Baghdad Iraq School of Dentistry Faculty of Medical Science University of Duhok Duhok Iraq Department of Dermatology and Venereology Baghdad Teaching Hospital Baghdad Iraq

Background: Recurrent aphthous ulcer (RAS) is a common oral disease where its etiopathogenesis is not well elucidated. There was no effective curative therapy for this disease. Isotretinoin has been recently used in the treatment of Behcet’s disease. Objectives: To evaluate the efficacy and safety of isotretinoin in treating RAS and the long term remission of RAS. Patients and Methods: This single-blind controlled therapeutic study conducted in Department of Dermatology-Baghdad Teaching Hospital during February 2011-January 2012. Thirty patients with typical RAS were included in this work. Detailed history and full examination were done for all patients. They were given isotretinoin 20 mg orally once daily for three months to be seen on Day 14 firstly and then monthly to be assessed using the oral clinical manifestation index (OCMI). After isotretinoin was stopped three months later, patients were given placebo therapy for another 3 months. Results: The results of 30 treated patients were as follows: 17 (56.67%) males and 13 (43.33%) females with male to female ratio was 1.3:1. Their ages ranged from 12 - 60 (35.33 ± 12.06) years. The OCMI before isotretinoin therapy ranged from 7 - 17 (13.13 ± 2.55), while after therapy the mean started to decline to a lower level within the first 14 days (P = 0.103), and continued to decline significantly until the end of the first month of therapy (P = 0.023). Then the OCMI declined very significantly until the end of fourth month of therapy (P < 0.001). After that the mean started to increase until the end of the 5 months (with placebo) but it remained statistically significant compared with the baseline of mean of OCMI before treatment (P = 0.046). Then it continued to increase to become not significant at the end of 6 months of therapy (P = 0.107). Conclusion: Isotretinoin is an effective therapeutic and prophylactic promising remedy in treatment of RAS.

关键词： Recurrent aphthous Stomatitis Isotretinoin Iraq

The Local Immunity of the Oral Cavity in Women with Recurrent aphthous Stomatitis Associated with Urogenital Infection

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Open Journal of Stomatology 2019年第1期9卷 1-8页

作者： Оlga А. Uspenskaya Larisa N. Kazarina Еlena А. Shevchenko Josef Herbert Department of Therapeutic Stomatology Federal State Budgetary Educational Institution of Higher Education &laquo Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia Department of Propaedeutic Dentistry Federal State Budgetary Educational Institution of Higher Education &laquo Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia Department of Pathological Physiology Federal State Budgetary Educational Institution of Higher Education &laquo Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia Dentist Running in Own Practice Sch&ouml nebeck Germany

This paper studied the dynamics of local immunity factors of the oral cavity in women with recurrent aphthous stomatitis against the background of urogenital infection. The research proves the maximum efficacy of hydroxyzine hydrochloride, aminodihydrophthalasindione sodium and Eplan used in multiple treatments of recurrent aphthous stomatitis in patients with urogenital infection as evidenced by a marked reduction in the coefficient of local immunity factors balance, which is observed as early as on day 7 of the therapy provided. Moreover, the findings show the growth of immunological parameters of oral fluid (lysozyme and SIgA), the normalization of the coefficient of local immunity factors balance in the treatment of recurrent aphthous stomatitis in women with urogenital infection, the improvement being observed 3 months after the treatment suggesting a favorable local immunity of the oral cavity.

关键词： Hydroxyzine Hydrochloride Aminodihydrophthalasindione Sodium Eplan Chronic Recurrent aphthous Stomatitis Coefficient of Local Immunity Factors Balance Secretory IgA Lysozyme Immunoglobulin A G

Treatment of Recurrent aphthous Stomatitis by 100% Topical Pumpkin Seed Oil

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第4期7卷 324-335页

作者： Khalifa E. Sharquie Adil A. Noaimi Tuqa M. Latif Department of Dermatology College of Medicine University of Baghdad Iraqi and Arab Board for Dermatology and Venereology Baghdad Teaching Hospital Medical City Baghdad Iraq Department of Dermatology Baghdad Teaching Hospital Medical City Baghdad Iraq

Background: Recurrent aphthous stomatitis (RAS) is a major oral health problem, where its etiopathogenesis is not well understood. Accordingly, its therapy whether topical or systemic can induce clearance, but the relapse rate is high. Objective: To use 100% topical pumpkin seed oil in RAS as it has many actions as anti-inflammatory and antioxidant effects. Patients and Methods: This single, blind, clinical, therapeutic trial was conducted in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq, during February 2015-August 2016. Twenty-five patients with RAS were included in this work. After full history and clinical examination, the clinical diagnosis was established. Oral clinical manifestation index score (OCMI) was carried out before, during and after stopping therapy to assess the different parameters of this score. 100% Topical pumpkin seed oil was given two times daily for 3 months during which short term assessment for each patient was done by using OCMI before, after 4 days and after 8 days of therapy in addition to assessing the mean size of largest diameter of ulcers in each visit to evaluate the therapeutic efficacy of the therapy, while long term assessment of the OCMI was done every month for 3 months after starting of the therapy to evaluate the prophylactic effect of the therapy. After 3 months, pumpkin seed oil was stopped and assessment of OCMI was done monthly for another 3 months to evaluate the remission action of pumpkin seed oil. Results: Twenty-five patients were included in this study: 15 (60%) males and 10 (40%) females. While their ages ranged from 9 - 60 (27.48 ± 11.97) years. The mean of OCMI before pumpkin seed oil therapy was ranged from 9 - 15 (12.96 ± 1.42), while after the therapy the mean started to decline to lower level within 4 days of therapy and was statistically significant (p < 0.0001) and continued to decline significantly till the end of third month of therapy (p < 0.0001). The percent reduction was 79.30

关键词： Recurrent aphthous Stomatitis Pumpkin Seed Oil Therapy

RADIOIMMUNOASSAY OF SERUM FERRITIN LEVEL IN PATIENTS WITH RECURRENT aphthous ULCERATION

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Medical Bulletin of Shanghai Jiaotong University 1991年第2期14卷 70-74页

作者：程慧许国祺张庆华曹宏康史慧宝 Department of Oral Medicine School of Stomatology SSMU Shanghai

The purpose of this study was to assess the correlation between iron deficiency and recurrent aphthous ulceration (RAU). Radioimmunoassay was used to examine the serum ferritin level (SFL) in 52 patients with RAU and in 54 controls. Both were divided into 2 groups in accordance with sex. The 36 female patients were subdivided into 3 age-groups as follows: 8 aged 22-24, 10 aged 25-34, and 18 aged 35-50 while the male patients were gathered as one single group aged 26-57. The subdivision was adapted similarly for the normal age-grouts. Although no significant difference in SFL was found between the male control and the male patient groups, differences between the female control and female patient groups showed highly significant which levels, with the ascendance of age, were P<0.001, P<0.005 and P<0.001, respectively. Also the difference between male and female control groups were significant (P<0.05). However, no significant differences in SFL were discovered among the 3 patient groups. 10 female patients with SFL<12ng/ml were tested with ferrous sulfate for one month, then their SFL was reexamined one week after the treatment. A highly significant difference in SFL was noted between the pre-ad post-treatment (P<0.001). 9 of them showed that the interval of recurrences were prolonged, the number of ulcers reduced, the pain less intensive and its duration shorter than those before the treatment. This study demonstrated that a singificant decrease in iron-storage occurred in female RAU patients. The authors concluded that the decrease SFL was possibly related to menstruation and child bearing.

关键词： recurrent aphthous ulceration serum ferritin level

Successful Treatment of PFAPA (Periodic Fever, aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome with Shinbuto

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International Journal of Clinical Medicine 2014年第20期5卷 1261-1264页

作者： Yuichirou Tsuji Chitose Karasawa Department of Pediatrics Tokyo Takanawa Hospital Tokyo Japan

Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is an autoimmune disorder and the most common disorder characterized by periodic fever in children. A male patient has been followed up from 11 months to 10 years of age because of repeated high fever. We prescribed antifebriles and antibiotics for each febrile episode without a beneficial effect to him each time. He required several days of rest at home to recover from each episode. During his most recent febrile episode at 10 years of age, we prescribed 5.0 g of shinbuto (TJ-30;Tsumura Co., Tokyo, Japan). His fever resolved the next day and he was able to attend school. His growth and development are normal. Shinbuto had a therapeutic effect in this patient with PFAPA syndrome and may be useful in this condition.

关键词： Periodic Fever aphthous PFAPA Syndrome Shinbuto

HOW TO TREAT SIMULTANEOUS OCCURRENCE OF COLD AND HEAT SYNDROMES WITH ACUPUNCTURE AND MOXIBUSTION?

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Journal of Traditional Chinese Medicine 1997年第1期17卷 75-76页

作者：郑其伟 Institute of Acupuncture and Moxibustion China Academy of Traditional Chinese Medicine 100700

By simultaneous occurrences of cold and heat syndromes we mean the presence of cold-syndrome and heat-syndrome in the body of a same person such as heat-syndrome in the upper part with cold-syndrome in the lower part ... 详细信息

关键词： acupuncture clearing warming moxibustion simultaneous sensation minutes aphthous body regulating

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青梅口腔双层贴膜的研制与应用

中国中医药科技 2015年第2期22卷 236-236,F0003页

作者：王铁烽金荣祥浙江省绍兴市中医院绍兴312000

复发性阿弗他溃疡（recurrent aphthous ulcer,RAU）是口腔黏膜病中最常见的疾病之一,患病率高达20%,是以溃疡、红肿、灼痛和周期性复发为特点的口腔黏膜自限性溃疡性损害。其发病原因尚不明确,可能是遗传、免疫、营养、感染、内分泌、... 详细信息

复发性阿弗他溃疡（recurrent aphthous ulcer,RAU）是口腔黏膜病中最常见的疾病之一,患病率高达20%,是以溃疡、红肿、灼痛和周期性复发为特点的口腔黏膜自限性溃疡性损害。其发病原因尚不明确,可能是遗传、免疫、营养、感染、内分泌、系统性疾病、环境和精神等多因素综合作用的结果[1]。青梅口腔双层贴膜是在我院制剂青梅散[2]的基础上加以改良而成的,从而使其疗效更加确切.

关键词：贴膜青梅散周期性复发 aphthous 自限性包合物系统性疾病免疫抑制剂恒温干燥箱滤液浓缩