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Jiawei Xiaoyao San in treatment of anxiety disorder and anxiety:A review

Chinese Herbal Medicines 2023年第2期15卷 214-221页

作者： Jiaqi Xie Dandan Xu Can Wang Jianmei Huang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

Jiawei Xiaoyao San(JWXYS)has shown excellent clinical efficacy in anxiety disorder,but has not yet attracted widespread *** animal experiments,clinical trials and mechanism studies of JWXYS were reviewed in this article,which may provide a reference for developing new anxiolytic drugs based on this *** literature was searched in PubMed and CNKI and the documents written in English or with English abstracts were *** could reduce the anxiety symptoms of patients alone and reduce the adverse reactions when it is used in combination with other drugs in the *** preclinical studies,JWXYS also showed therapeutic effects in reducing anxiety-like *** mechanisms may include improving the hypothalamic–pituitaryadrenal(HPA)axis and hormone disorders,increasing neurotransmitter content,neurogenesis,and regulating the synthesis of related *** article shows that JWXYS could effectively treat anxiety disorders by regulating the central nervous *** the future,with the participation of more researchers,it is expected to develop innovative drugs for the treatment of anxiety disorders based on JWXYS.

关键词： anxiolytic activity anxiety disorder Jiawei Xiaoyao San

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Identification of anxiolytic Potential of Niranthin:In-vivo and Computational Investigations

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Natural Products and Bioprospecting 2021年第2期11卷 223-233页

作者： Atul R.Chopade Prakash M.Somade Pratik P.Somade Suraj N.Mali Department of Pharmacology Rajarambapu College of PharmacyKasegaonSangliMaharashtra 415404India Dept.of Physiology Krishna Institute of Medical SciencesKaradMaharashtraIndia Government College of Pharmacy KaradMaharashtraIndia

Anxiety is an unpleasant state,which can critically decrease the quality of life is often accompanied by nervous behaviour and *** is a lignan isolated from various Phyllanthus *** literature survey on niranthin highlights wide ranges of the therapeutic *** a present study,based on our previous investigations,we evaluated pure,isolated and characterized niranthin as an anxiolytic *** niranthin[6-[(2R,3R)-3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole]was purchased from commercial source and further subjected for assessment of its anxiolytic potentials using popular animal models including Elevated plus-maze model/test(EPM)and Light&Dark Exploration test(L&D).GABA-A receptor mediation was evaluated by pretreating the mice with the GABA-A receptor antagonist Flumazenil before the EPM *** docking simulation studies(pdb id:4COF)carried out by Vlife QSAR software showed that niranthin(docking score:−62.1714 kcal/mol)have shown comparatively best docking score compared to the standard drug Diazepam(docking score:−63.1568 kcal/mol).To conclude,Niranthin has probable potential in the management of anxiety *** in-silico and in-vivo analysis(indirectly)indicated the plausible role of GABA mediation for anxiolytic ***,these studies are preliminary,future in depth experimental explorations will be required to use Niranthin as anti-anxiety drug in near future.

关键词： Pharmacology Phytoconstituents Niranthin Lignan anxiolytic activity EPM models

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