Identification of Anxiolytic Potential of Niranthin:In-vivo and Computational Investigations
作者机构：Department of PharmacologyRajarambapu College of PharmacyKasegaonSangliMaharashtra 415404India Dept.of PhysiologyKrishna Institute of Medical SciencesKaradMaharashtraIndia Government College of PharmacyKaradMaharashtraIndia
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2021年第11卷第2期
页 面：223-233页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 070303[理学-有机化学] 0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学]
基 金：support provided by Rajarambapu College of Pharmacy,Kasegaon,Sangli-415404 Maharashtra,India and Krishna institute of medical sciences,Karad,Maharashtra,India for carrying out this research
主 题：Pharmacology Phytoconstituents Niranthin Lignan Anxiolytic activity EPM models
摘 要：Anxiety is an unpleasant state,which can critically decrease the quality of life is often accompanied by nervous behaviour and *** is a lignan isolated from various Phyllanthus *** literature survey on niranthin highlights wide ranges of the therapeutic *** a present study,based on our previous investigations,we evaluated pure,isolated and characterized niranthin as an anxiolytic *** niranthin[6-[(2R,3R)-3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole]was purchased from commercial source and further subjected for assessment of its anxiolytic potentials using popular animal models including Elevated plus-maze model/test(EPM)and Light&Dark Exploration test(L&D).GABA-A receptor mediation was evaluated by pretreating the mice with the GABA-A receptor antagonist Flumazenil before the EPM *** docking simulation studies(pdb id:4COF)carried out by Vlife QSAR software showed that niranthin(docking score:−62.1714 kcal/mol)have shown comparatively best docking score compared to the standard drug Diazepam(docking score:−63.1568 kcal/mol).To conclude,Niranthin has probable potential in the management of anxiety *** in-silico and in-vivo analysis(indirectly)indicated the plausible role of GABA mediation for anxiolytic ***,these studies are preliminary,future in depth experimental explorations will be required to use Niranthin as anti-anxiety drug in near future.
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