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Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposureinduced anxiety-like behaviors in offspring

Environmental Science and Ecotechnology 2023年第1期13卷 125-133页

作者： Xingwang Ding Ya Wen Xuan Ma Yuepei Zhang Yuting Cheng Zhaofeng Liu Weiyue Hu Yankai Xia State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical University101 Longmian AvenueJiangning DistrictNanjing211166China Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical University101 Longmian AvenueJiangning DistrictNanjing211166China Department of Chronic Non-Communicable Disease Control Wuxi Liangxi District Center for Disease Control and PreventionWuxi214011China Department of Nutrition and Food Safety School of Public HealthNanjing Medical UniversityNanjing211166China

Pyridaben(PY)is a widely used organochlorine acaricide,which can be detected in the peripheral blood of pregnant *** evidence suggests that PY has reproductive ***,it remains uncertain whether prenatal PY exposure impacts neurobehavioral development in ***,we administered PY to pregnant mice at a dose of 0.5 and 5 mg kg^(-1)day^(-1)via gavage and observed anxietylike behaviors in PY offspring aged five *** then integrated the metabolome and transcriptome of the offspring's brain to explore the underlying *** data indicated that the vitamin B6 metabolism pathway was significantly affected,and the pyridoxal 50-phosphate(PLP)concentration and the active form of vitamin B6 was significantly ***,the transcriptome data showed that both PLP generation-related Pdxk and anxiety-related Gad1 were significantly ***,there was a decreasing trend in the concentration of GABA in the hippocampal DG ***,we supplemented PLP at a dose of 20 mg kg^(-1)day^(-1)to the PY offspring via intraperitoneal injection at three *** found up-regulated expression of Pdxk and Gad1 and restored anxiety-like *** study suggests that prenatal exposure to PY can disrupt vitamin B6 metabolism,reduce the concentration of PLP,down-regulate the expression levels of Pdxk and Gad1,inhibit the production of GABA,and ultimately lead to anxiety-like behaviors in offspring.

关键词： Pyridaben Prenatal exposure Pyridoxal 50-phosphate anxiety-like behaviors

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针刺应答是否随针刺剂量增加而增大:一项基于睡眠剥夺大鼠的临床前研究

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World Journal of Acupuncture-Moxibustion 2020年第3期30卷 207-216页

作者：赵非一徐燕王国华马恰怡岳立萍许红李志敏付强强上海杉达学院国际医学技术学院护理系中国上海201209 上海中医药大学附属市中医医院中国上海200071 上海天山中医医院中国上海200051 同济大学附属杨浦医院科研处中国上海200090

Background:The effectiveness of acupuncture for insomnia and insomnia-related anxiety and depression has been widely investigated in clinical ***,whether higher dosage(more frequent)acupuncture can bring greater responses(a greater size of effect)is less ***:This study is designed to investigate whether a five-times weekly(5 Ts/w)electroacupuncture(EA)treatment is better than a three-times weekly(3 Ts/w)EA in alleviating sleep deprivation,and sleep disturbance-induced cognitive dysfunctions and negative emotions in rats through four various behavioral te ***:Forty-six male Sprague-Dawley rats were randomly divided into control group(n=10),model group(n=12),EA-3 Ts/w group(n=12),and EA-5 Ts/w group(n=12).Except for the control group,the other three groups were established as chronic sleep deprivation models via the modified multi-platform water environment ***,rats in both EA-3 Ts/w group and EA-5 Ts/w group received corresponding dosage of EA therapy,*** modeling and interventions,all four groups received four behavioral tests as follows:(1)sleep behavioral monitoring and evaluation was achieved by Comprehensive Lab Animal Monitoring System(CLAMS).(2)Cognitive functions were assessed by Novel Object Recognition(NOR)test.(3)Depressive-like behaviors was evaluated by Open-Field(OF)test.(4)anxietylike behaviors was appraised by Elevated Plus-Maze(EPM)*** finishing the behavioral tests,the hippocampus of each rat was removed and its synaptic structure changes were observed under electron ***:(1)CLAMS:two EA groups derived more sleep time within 24 h than the model group(both P0.05).(2)NOR test:NOR ratio in the EA-3 Ts/w group was higher than that of the model group(P<0.05)but lower than that of either the control group(P<0.05)or the EA-5 Ts/w group(P<0.05).(3)OF test:the difference of horizontal movements bet

关键词： Electroacupuncture Sleep deprivation Depressive-like behaviors anxiety-like behaviors Behavioral test

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