检索结果-南通市图书馆

Synthesis, Crystal Structure and antitumor activity of 6,7,8-Trimethoxy-1-(4-methoxy-3-nitrophenyl)-4- (pyridin-4-ylmethyl)-3,4-dihydroisoquinoline

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2011年第5期30卷 717-723页

作者：朱雯雯宋云龙郑灿辉吕加国陈军黄晶晶周有骏朱驹 Department of Medicinal Chemistry School of PharmacyThe Second Military Medical University Department of Pharmacy Chengdu Military Command General Hospital

A novel class of 3,4-dihydroisoquinolines （7a～e） was designed, synthesized and characterized by IR, NMR and ESI-MS. The crystal structure of compound 7a （6,7,8-trime- thoxy-1-（4-methoxy-3-nitrophenyl）-4-（pyridin-4-methyl）-3,4-dihydroisoquinoline, C25H25N3O6, Mr=463.48） was determined by X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group P21/n with a=12.074（5）, b=12.896（6）, c=15.450（7）, β=105.846（5）°, V=2314.4（17） 3, Z=4, Dc=1.330 Mg/m3, μ（MoKα）=0.096 mm-1, F（000）=976, S=0.991, the final R=0.0467 and wR=0.1231 for 4545 unique reflections （Rint=0.0656） with 3117 observed ones. The bioassay showed that compounds 7a～e exhibit moderate antitumor activities in vitro.

关键词： 3,4-dihydroisoquinoline crystal structure synthesis antitumor activity

Synthesis, Characterization and antitumor activity of Lanthanum(Ⅲ) Complex with Demethylcantharidate

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2005年第5期23卷 596-599页

作者：尹富玲邹嘉佳许玲王煦李荣昌 Department of Chemical Biology School of Pharmaceutical Science Peking University Beijing 100083 China

A novel complex of lanthanum （ Ⅲ ） with demethylcantharidate group （DCA）, Na [ La （DCA） 2 （H2O） ], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, UV, ^1H-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MT＇F or SRB assays. Na[La（DCA）2（H2O）] exhibits stronger inhibition against certain kinds of cancer cells than Na2DCA in vitro.

关键词： lanthanum complex demethylcantharidate group antitumor activity rare earths

Crystal Structure and antitumor activity of Tri[2- [N-(4'-methyl-benzylsulfonyl)amino]ethyl]-amine

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2003年第4期22卷 411-414页

作者：台夕市尹显洪谭民裕李一志 College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 ChinaDepartment of Chemistry Guangxi University for Nationalities Nanning 530006 China Coordination Chemistry Institute State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210093 China

The crystal structure of the title compound (C27H38N4O7S3, Mr = 626.79) has been determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group Pīwith a = 9.411(1), b = 11.645(2), c = 14.672(2) , a = 91.80(1), b = 95.36(1), g =104.56(1)o, V = 1547.0 3, Z = 2, Dc = 1.346 g/cm3, l = 0.71073 , m(MoKa) = 0.289 mm-1 and F(000) = 664. The structure was refined to R = 0.0406 and wR = 0.1177 for 4103 observed reflections with I > 2s(I). X-ray diffraction analysis reveals that the title compound is a practically distorted tetrahedron and each molecule contains one lattice H2O by hydrogen bond. The antitumor activity of the title compound against HL-60 human leukemia cells has also been studied by MTT method.

关键词： crystal structure distortion tetrahedron antitumor activity

A Novel 5-Fluorouracil Salt of 12-Silicatungstic Acid: Synthesis,Structure Characterization and antitumor activity

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2005年第2期21卷 127-130页

作者： LIJuan WUXin-yu LIJing WANGHong-fang QIYan-fei YUXi-he SUNZhi-wei WANGEn-bo DepartmentofHygienicChemistry SchoolofPublicHealthJilinUniversityChangchun130021P.R.China InstituteofPolyoxometalateChemistry FacultyofChemistryNortheastNormalUniversityChangchun130024P.R.China

A novel 5-fluorouracil salt of 12-silicatungstic acid was synthesized and characterized by means of elemental analysis, IR, 1H NMR and 183W NMR spectra. The antitumor activity and toxicity of the complex have been eva... 详细信息

关键词： Polyoxotungstate 5-Fu antitumor activity Toxicity

Pharmacological Study on antitumor activity of 5-Fluorouracil-1-Acetic Acid and Its Rare Earth Complexes

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2000年第2期18卷 140-143页

作者： Yang, Zheng-Yin Wang, Liu-Fang Yang, Xin-Ping Wang, Da-Wei Li, Yu-Ming Dept. of Chem. Lanzhou Univ. Lanzhou 730000 China

The antitumor activity of 5 fluorouracil 1 acetic acid(HFAA) and its lanthanide complexes(La(FAA) 3, Eu(FAA) 3) were studied. The results show that HFAA, La(FAA) 3 and Eu(FAA) 3 with the concentrations of 1 0×10 -5 ～1 0×10 -2 μg·ml -1 inhibit the colony formation of leukemia cells(L 1210 ) and the growth of transplanted tumor sarcoma 180(S 180 ), hepatic carcinoma(HEPA) and ehrlich ascites tumor(EC) as well. The maximum inhibitory rate of Eu(FAA) 3 for S 180 is 38 4%, that HFAA and La(FAA) 3 for EC are 22 4% and 43 4%, respectively. The life prolongation rate of Eu(FAA) 3 for HEPA bearing mice is as long as 284%.

关键词： rare earths antitumor activity 5 fluorouracil 1 acetic acid

Study on the Synthesis and antitumor activity of New Indolocarbazole Compounds

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2016年第2期35卷 205-211页

作者： ZHAO Ling-Ling ZHAI Fu-Min XIE Ming-Chao QI Ganga Department of Chemistry and Chemical Engineering Yancheng Institute of TechnologyYancheng 224051China Jiangsu Wanquan Pharmaceutical Biotechnology Company Taizhou 225300China Binhai County Safety Supervision Bureau Yancheng 224500China

A series of new antitumor compounds having indolecarbazole structures were designed and synthesized. The methoxy substituted indolecarbazole parent nucleus, which was firstly synthesized, is condensed with bromine substituted amino acid methyl ester to produce the target compounds. The target compounds were performed with methylthiazolyldiphenyl-tetrazolium bromide（MTT） in vitro cytotoxin activity test and the results showed that compounds CZ-1, CZ-3 and CZ-6 have higher activity against human colon cancer（HT-29） and（HCT-8）, hepatocellular carcinoma（Bel-7402）, NSCLC（A549） and breast cancer（MCF-7） cells as compared to the positive control JDC-108.

关键词： indolecarbazole antitumor activity cytotoxin activity

Synthesis and antitumor activity of Novel Coumarin Deriva- tives via a Three-component Reaction in Water

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2013年第4期31卷 507-514页

作者： Zhiwei Chen Jianhao Bi Weike Su Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education College of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou Zhejiang 310014 China

An efficient synthesis of novel coumarin derivatives via a three-component condensation of 4-hydroxycoumarin, aldehydes and aromatic amines catalyzed by sulfonic acid functionalized ionic liquid L-2-（hydroxymethyl）- 1-（4-sulfobutyl）pyrrolidinium hydrogen sulfate （[HYSBPI]·HSO4） is reported. The condensed product was obtained with excellent yields in water under microwave irradiation condition. The antitumor activities of all the synthesized compounds were assessed on two different human cancer cell lines （A-549 and MCF-7）, and the results showed that these compounds had weak-to-good antitumor activities and their IC50 ranged from 0.05 to more than 100 μmol.L-1.

关键词： coumarins multicomponent reactions antitumor activity sulfonic acid functionalized ionic liquids

Argentum 5-Hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate:Synthesis,Crystal Structure and antitumor activity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2020年第10期39卷 1898-1905,1746页

作者： LI Wu-Wu ZHENG Min-Yan GAO Yi-Hong ZHANG Zun-Ting College of Chemistry&Chemical Engineering Xianyang Normal UniversityXianyang 712000China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China and School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'an 710062China

In order to improve the water solubility and bioavailability of 5-hydroxy-7-methoxyflavone,argentum 5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate[Ag4(H2O)6](C(16)H(11)O4SO3)4·H2O(1,C(16)H(11)O4SO3=5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate)was synthesized by sulfonation *** structure of 1 was characterized by FT-IR,elemental analysis and X-ray single-crystal *** 1 belongs to the triclinic system,space group P1,a=8.077(4),b=12.365(4),c=17.735(7)A,V=1685.0(12)A3,Z=1,μ=1.372 mm^–1,Dc=1.936 g/cm^3,F(000)=984,the final R=0.0819 and wR=0.2332 with I>2σ(I).3D structure of 1 exhibits alternating organic and inorganic regions.O–H×××O hydrogen bonds and Ag–O coordination interactions exist among crystal water,coordinated water and sulfo group,which constructed an organic *** skeletons form organic region of *** group is the bridge linking these two *** in vitro antitumor activity of 1 against human lymphoma cells U937 and human breast cancer cells MCF-7 were evaluated with CCK-8 *** result shows that 1 showed inhibitory activity against tumour cell U937 and MCF-7,and indicated that flavone sulfonate derivatives may be potential leads for further biological screenings and may generate drug-like molecules.

关键词： argentum 5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate sulfonation reaction crystal structure antitumor activity

Structure elucidation,immunomodulatory activity,antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2023年第2期12卷 647-661页

作者： Siyuan Su Xiang Ding Yiling Hou Binbin Liu Zhouhe Du Junfeng Liu Key Laboratory of Southwest China Wildlife Resources Conservation College of Life SciencesChina West Normal UniversityNanchong 637009China Sericultural Research Institute Sichuan Academy of Agricultural SciencesNanchong 637000China College of Environmental Science and Engineering China West Normal UniversityNanchong 637009China

A new water-soluble heteropolysaccharide with a molecular weight of 15 k Da was isolated from the fruiting bodies of Boletus reticulatus *** characterization results revealed that *** Schaeff polysaccharide(BRS-X)had a backbone of 1,6-linkedα-D-galactose and 1,2,6-linkedα-D-galactose which branches were mainly composed of a terminal 4-linkedβ-D-glucose and the ratio of D-galactose and D-glucose was 5:*** assays indicated that BRS-X displayed a strong proliferative activity in T cells and B cells and promoted the secretion of immunoglobulin G(Ig G),Ig E,Ig D and Ig *** addition,BRS-X could facilitate the proliferation and phagocytosis of RAW264.7 cells and could significantly inhibit the growth of tumors in S180-bearing *** results of transcriptome sequencing analysis illustrated that total 46 genes enriched in MAPK and total 34 genes enriched in PI3 K/Akt signaling pathways in BRS-X *** protein VEGF and VEGFR expression were significantly reduced under the treatment with *** findings provide a scientific basis for the edible and medicinal value of BRS-X.

关键词： Boletus reticulatus Schaeff Polysaccharides Structure identification Immunomodulatory activity antitumor activity