Pharmacological Study on Antitumor Activity of 5-Fluorouracil-1-Acetic Acid and Its Rare Earth Complexes

作     者：Yang, Zheng-Yin Wang, Liu-Fang Yang, Xin-Ping Wang, Da-Wei Li, Yu-Ming 

作者机构：Dept. of Chem. Lanzhou Univ. Lanzhou 730000 China 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：2000年第18卷第2期

页      面：140-143页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 0709[理学-地质学] 0819[工学-矿业工程] 0708[理学-地球物理学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：ProjectsupportedbyChinaPostdoctoralScienceFoundationandtheNationalNaturalScienceFoundationofChina( 2 9975 0 12 ) 

主　　题：rare earths antitumor activity 5 fluorouracil 1 acetic acid 

摘      要：The antitumor activity of 5 fluorouracil 1 acetic acid(HFAA) and its lanthanide complexes(La(FAA) 3, Eu(FAA) 3) were studied. The results show that HFAA, La(FAA) 3 and Eu(FAA) 3 with the concentrations of 1 0×10 -5 ～1 0×10 -2 μg·ml -1 inhibit the colony formation of leukemia cells(L 1210 ) and the growth of transplanted tumor sarcoma 180(S 180 ), hepatic carcinoma(HEPA) and ehrlich ascites tumor(EC) as well. The maximum inhibitory rate of Eu(FAA) 3 for S 180 is 38 4%, that HFAA and La(FAA) 3 for EC are 22 4% and 43 4%, respectively. The life prolongation rate of Eu(FAA) 3 for HEPA bearing mice is as long as 284%.