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Potential antioxidant properties and hepatoprotective effects of Juniperus phoenicea berries against CCl4 induced hepatic damage in rats

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 249-255页

作者： Amel Laouar Fahima Klibet Ezzeddine Bourogaa Amel Benamara Amel Boumendjel Azzedine Chefrour Messarah Mahfoud Laboratory of Biochemistry and Environmental Toxicology Faculty of SciencesUniversity of Badji MokhtarAnnaba 23000Algeria Department of Biochemistry and Biological Cellular and Molecular Faculty of SciencesUniversity of MentouriBP 25000 ConstantineAlgeria Laboratoryof Animal Ecophysiology Faculty of SciencesSfaxSoukra road-Km 3.5BP 8023018 SfaxTunisia Department of Applied Biology Faculty of Natural Sciences and LifeUniversity of Larbi TebessiTebessa 12000Algeria Laboratory of pharmaceutical preparations for hospital use Department of PharmacyFaculty of MedicineUniversity of Badji Mokhtar-Annaba 23000Algeria Department of Biology Faculty of Natural Sciences and LifeUiversity of Mohamed Cherif MesaadiaSouk Ahras 41000Algeria

Objective:To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea(***)berries against CCl_4-induced oxidative damage in ***:Hepatotoxicity was induced in albino Wistar rats by single dose of CCl_4 dissolved in olive oil(1 mL/kg BW,1/1 in olive oil,ip).Aqueous extract of *** berries(AEJP)was administered at the dose of 250 mg/kg/day by gavage for 12 ***:Obtained results revealed that administration of CCl_4 caused a significant increase in plasma ASAT,ALAT,ALP and LDH activities and total bilirubin concentration,compared to the control ***,albumin and total protein concentration were significantly ***,a significant decrease in the level of hepatic GSH,GPx and GST activities associated with a significant increase of MDA content in CCl_4 group than those of the ***,the treatment of experimental rats with AEJP prevented these alterations and maintained the antioxidant *** histopathological observations supported the biochemical evidences of ***:The results of the present investigation indicate that *** possesses hepatoprotective activity and this effect was may be due to its antioxidant proprerties.

关键词： Juniperus phoenicea Oxydative stress antioxydant Lipid peroxidation Hepatoprotective Biochemical parameters

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Synthesis, Spectroscopy and Electrochemistry of New 3-(5-Aryl-4,5-Dihydro-1H-Pyrazol-3-yl)-4-Hydroxy-2H-Chromene-2-One 4, 5 as a Novel Class of Potential Antibacterial and Antioxidant Derivatives

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International Journal of Organic Chemistry 2011年第3期1卷 87-96页

作者： Abdullah Sulaiman Al-Ayed 不详

3-((2E)-3(aryl)prop-2-enoyl)-2H-chromen-2-one 3 was synthesized from 4-hydroxy coumarin by refluxing 3-acetyl-4-hydroxy coumarin with aromatic aldehydes in chloroform in the presence of a catalytic amount of piperidine. 3 was converted to pyrazoles 4, 5 by treatment with hydrazine and phenylhydrazine in toluene, respectively. The structures of the new compounds were confirmed by elemental analysis, IR, and multinuclear/multidimensional NMR spectroscopy (1H, 13C-NMR, NOESY, HMBC) which allowed us to assign the complete network of proton and carbon atoms. All the compounds exhibited one quasireversible redox process. All the newly synthesized compounds were screened for their antibacterial and antioxidant activities. Antimicrobial studies revealed that 3-(5-(2,5-dimethylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-4- hydroxy-2H-chromene-2-one 5c showed significant antibacterial activity against Escherichia coli and Pseudomonas Aeruginosa 27853. Furthermore, 3-(5-(aryl)-4,5-dihydro-1H-pyrazol-3-yl)-4-hydroxy-2H-chromene- 2-ones 4, 5 showed antioxidant activities of different extents with respect to individual compounds as well as to the antioxidant methods. The 3-(5-(phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4-hydroxy-2H-chromene-2-ones 4a was found to be the most active antioxidant in the series and more active than trolox which makes the investigated complexes a new promising class of antibacterial compounds.

关键词： 4-Hydroxycoumarin Pyrazole Antibacterial Activity antioxydant Activity

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