Potential antioxidant properties and hepatoprotective effects of Juniperus phoenicea berries against CCl4 induced hepatic damage in rats

作     者：Amel Laouar Fahima Klibet Ezzeddine Bourogaa Amel Benamara Amel Boumendjel Azzedine Chefrour Messarah Mahfoud 

作者机构：Laboratory of Biochemistry and Environmental ToxicologyFaculty of SciencesUniversity of Badji MokhtarAnnaba 23000Algeria Department of Biochemistry and Biological Cellular and MolecularFaculty of SciencesUniversity of MentouriBP 25000 ConstantineAlgeria Laboratoryof Animal EcophysiologyFaculty of SciencesSfaxSoukra road-Km 3.5BP 8023018 SfaxTunisia Department of Applied BiologyFaculty of Natural Sciences and LifeUniversity of Larbi TebessiTebessa 12000Algeria Laboratory of pharmaceutical preparations for hospital useDepartment of PharmacyFaculty of MedicineUniversity of Badji Mokhtar-Annaba 23000Algeria Department of BiologyFaculty of Natural Sciences and LifeUiversity of Mohamed Cherif MesaadiaSouk Ahras 41000Algeria 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2017年第10卷第3期

页      面：249-255页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Algerian Ministry of Higher Education and Scientific Research Directorate General for Scientific Research and Technological Development through the research Laboratory'Laboratory of Biochemical and Environmental Toxicology'Faculty of sciences University of Badji Mokhtar Annaba Algeria 

主　　题：Juniperus phoenicea Oxydative stress Antioxydant Lipid peroxidation Hepatoprotective Biochemical parameters 

摘      要：Objective:To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea(***)berries against CCl_4-induced oxidative damage in ***:Hepatotoxicity was induced in albino Wistar rats by single dose of CCl_4 dissolved in olive oil(1 mL/kg BW,1/1 in olive oil,ip).Aqueous extract of *** berries(AEJP)was administered at the dose of 250 mg/kg/day by gavage for 12 ***:Obtained results revealed that administration of CCl_4 caused a significant increase in plasma ASAT,ALAT,ALP and LDH activities and total bilirubin concentration,compared to the control ***,albumin and total protein concentration were significantly ***,a significant decrease in the level of hepatic GSH,GPx and GST activities associated with a significant increase of MDA content in CCl_4 group than those of the ***,the treatment of experimental rats with AEJP prevented these alterations and maintained the antioxidant *** histopathological observations supported the biochemical evidences of ***:The results of the present investigation indicate that *** possesses hepatoprotective activity and this effect was may be due to its antioxidant proprerties.