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Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity

Bioactive Materials 2022年第4期7卷 504-514页

作者： Lulu Wang Xiaokang Zhang Pingping Xu Jicheng Yan Yuzhong Zhang Hainan Su Chengjun Sun Qiang Lu Weizhi Liu Sars-Fang Centre MOE Key Laboratory of Marine Genetics and BreedingCollege of Marine Life SciencesOcean University of ChinaQingdao266003China Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and TechnologyQingdao266071China State Key Laboratory of Microbial Technology Marine Biotechnology Research CenterShandong UniversityQingdao266237China Key Laboratory of Marine Eco-environmental Science and Technology Marine Bioresource and Environment Research CenterFirst Institute of OceanographyMinistry of Natural Resources(MNR)Qingdao266061China National Engineering Laboratory for Modern Silk Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou215123China

antioxidant biomaterials have attracted much attention in various biomedical fields because of their effective inhibition and elimination of reactive oxygen species(ROS)in pathological ***,the difficulty in ensuring biocompatibility,biodegradability and bioavailability of antioxidant materials has limited their further *** bioavailable antioxidant materials that are derived from natural resources are urgently ***,an integrated multi-omics method was applied to fabricate antioxidant biomaterials.A key cysteine-rich thrombospondin-1 type Ⅰ repeat-like(TSRL)protein was efficiently discovered from among 1262 adhesive components and then used to create a recombinant protein with a yield of 500 mg L^(-1).The biocompatible TSRL protein was able to self-assemble into either a water-resistant coating through Ca^(2+)-mediated coordination or redox-responsive hydrogels with tunable physical *** TSRL-based hydrogels showed stronger 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging rates than glutathione(GSH)and ascorbic acid(Aa)and protected cells against external oxidative stress significantly more *** topically applied to mice skin,TSRL alleviated epidermal hyperplasia and suppressed the degradation of collagen and elastic fibers caused by ultraviolet radiation B(UVB)irradiation,confirming that it enhanced antioxidant activity in *** is the first study to successfully characterize natural antioxidant biomaterials created from marine invertebrate adhesives,and the findings indicate the excellent prospects of these biomaterials for great applications in tissue regeneration and cosmeceuticals.

关键词： Sessile marine organisms antioxidant biomaterials Water-resistant coatings Redox-responsive hydrogels Photoaging

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Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS

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Bioactive Materials 2021年第11期6卷 3839-3850页

作者： Jianmei Li Cuijun Deng Wanyuan Liang Fei Kang Yun Bai Bing Ma Chengtie Wu Shiwu Dong Department of Biomedical Materials Science School of Biomedical EngineeringThird Military Medical University(Army Medical University)Chongqing400038China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China State Key Laboratory of Trauma Burnsand Combined InjuryThird Military Medical University(Army Medical University)Chongqing400038China

Osteoporosis is caused by an osteoclast activation *** suffering from osteoporosis are prone to bone *** evidence indicates that scavenging reactive oxygen species(ROS)can inhibit receptor activator of nuclear factorκB ligand(RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced *** is critical to develop biomaterials with antioxidant properties to modulate osteoclast activity for treating osteoporotic bone *** studies have shown that manganese(Mn)can improve bone regeneration,and Mn supplementation may treat ***,the effect of Mn on osteoclasts and the role of Mn in osteoporotic bone defects remain *** present research,a model bioceramic,Mn-containedβ-tricalcium phosphate(Mn-TCP)was prepared by introducing Mn intoβ-*** introduction of Mn intoβ-TCP significantly improved the scavenging of oxygen radicals and nitrogen radicals,demonstrating that Mn-TCP bioceramics might have antioxidant *** in vitro and in vivo findings revealed that Mn^(2+)ions released from Mn-TCP bioceramics could distinctly inhibit the formation and function of osteoclasts,promote the differentiation of osteoblasts,and accelerate bone regeneration under osteoporotic conditions in ***,Mn-TCP bioceramics inhibited osteoclastogenesis and promoted the regeneration of osteoporotic bone defects by scavenging ROS via Nrf2 *** results suggest that Mn-containing bioceramics with osteoconductivity,ROS scavenging and bone resorption inhibition abilities may be an ideal biomaterial for the treatment of osteoporotic bone defect.

关键词： Mn-containing bioceramics antioxidant biomaterials Osteoclastogenesis ROS Osteoporotic bone regeneration

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