Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS

作     者：Jianmei Li Cuijun Deng Wanyuan Liang Fei Kang Yun Bai Bing Ma Chengtie Wu Shiwu Dong 

作者机构：Department of Biomedical Materials ScienceSchool of Biomedical EngineeringThird Military Medical University(Army Medical University)Chongqing400038China State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China State Key Laboratory of TraumaBurnsand Combined InjuryThird Military Medical University(Army Medical University)Chongqing400038China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第11期

页      面：3839-3850页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：the Key Program of National Natural Science Foundation of China(81930067) the Youth Program of National Natural Science Foundation of China(grant number 82002316) the Youth Cultivation Project of Army Medical University(2020XQN08) General Program of Natural Science Foundation of Chongqing(cstc2019jcyj-msxmX0176) 

主　　题：Mn-containing bioceramics Antioxidant biomaterials Osteoclastogenesis ROS Osteoporotic bone regeneration 

摘      要：Osteoporosis is caused by an osteoclast activation *** suffering from osteoporosis are prone to bone *** evidence indicates that scavenging reactive oxygen species(ROS)can inhibit receptor activator of nuclear factorκB ligand(RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced *** is critical to develop biomaterials with antioxidant properties to modulate osteoclast activity for treating osteoporotic bone *** studies have shown that manganese(Mn)can improve bone regeneration,and Mn supplementation may treat ***,the effect of Mn on osteoclasts and the role of Mn in osteoporotic bone defects remain *** present research,a model bioceramic,Mn-containedβ-tricalcium phosphate(Mn-TCP)was prepared by introducing Mn intoβ-*** introduction of Mn intoβ-TCP significantly improved the scavenging of oxygen radicals and nitrogen radicals,demonstrating that Mn-TCP bioceramics might have antioxidant *** in vitro and in vivo findings revealed that Mn^(2+)ions released from Mn-TCP bioceramics could distinctly inhibit the formation and function of osteoclasts,promote the differentiation of osteoblasts,and accelerate bone regeneration under osteoporotic conditions in ***,Mn-TCP bioceramics inhibited osteoclastogenesis and promoted the regeneration of osteoporotic bone defects by scavenging ROS via Nrf2 *** results suggest that Mn-containing bioceramics with osteoconductivity,ROS scavenging and bone resorption inhibition abilities may be an ideal biomaterial for the treatment of osteoporotic bone defect.