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Effect of yellow rice wine on anti-aging ability in aged mice induced by D-galactose

Food Science and Human Wellness 2020年第2期9卷 184-191页

作者： Rong Liu Zukang Fu Fengjie Zhang Qingzhong Mao Chunguang Luan Xinglin Han Jie Xue Deliang Wang Si Qin Feike Hao College of Food Science and Technology Hunan Agricultural UniversityChangsha410128China Kuaijishan Shaoxing Rice Wine CO.Ltd. Shaoxing312030China China National Research Institute of Food and Fermentation Industries Beijing100015China

The present study is focused on investigation of the health protective effect of yellow rice wine(YRW)in mice and the potential underlying *** of aging were induced in mice by using Dgalactose(D-gal),and different doses of YRW(4,8,and 12 mL/kg BW)were orally administrated to D-galtreated mice for a period of six *** in vivo data obtained in the present study preliminary indicated that YRW markedly increased the activity of antioxidant enzymes and reduced the concentration of MDA both in the brain and ***,a forced swim test showed that moderate intake of YRW(8 mL/kg BW)significantly decreased the duration of immobility,reduced the blood content of urea nitrogen and lactic acid,and increased hepatic glycogen ***,results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and *** above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action.

关键词： Yellow rice wine Aging Antioxidant antifatigue Cognitive impairment Apoptosis

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Ergogenic Capacity of a 7-Chinese Traditional Medicine Extract in Aged Mice

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Chinese Medicine 2012年第4期3卷 223-228页

作者： Jian-Rong Zhou Mohamed Aly M. Morsy Kiyoshi Kunika Kazumi Yokomizo Takeshi Miyata Department of Pharmacology Faculty of Medicine Minia University Minya Egypt Department of Presymptomatic Medical Pharmacology Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan Division of Science and Medicine Institute of International Kampo Co. Ltd. Nihonmatsu Japan

The ergogenic properties of a 7-Chinese traditional medicine water extract (Ligustrum lucidum ait, LLA), which is composed of the essences of Lycii fructus, Crataegi fructus, Phyllanthi fructus, Chrysanthemi flos, Coicis semen, Ganoderma lucidum, and Zizyphi fructus, were studied using aged mice. Mice were chronically (one month) administered LLA (0.1% and 1%) in the drinking water. Mice pre-treated with LLA showed a good appetite;however, they exhibited a lower rate of body weight increase compared to control mice. In mice subjected to the rotarod test, 1% LLA treatment provided effective adaption to fatigue and significantly increased the duration of mice on the rotarod. In locomotor activity test, 1% LLA potentiated mice mobility and significantly increased rearing behavior. In the antioxidant experiment, 1% LLA treatment significantly increased superoxide dismutase activity in the spleen and liver glutathione levels. These findings suggest that LLA may be utilized as an antifatigue agent, which may function through its antioxidant activity.

关键词： antifatigue Antioxidant Chinese Traditional Medicine

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