Effect of yellow rice wine on anti-aging ability in aged mice induced by D-galactose

作     者：Rong Liu Zukang Fu Fengjie Zhang Qingzhong Mao Chunguang Luan Xinglin Han Jie Xue Deliang Wang Si Qin Feike Hao 

作者机构：College of Food Science and TechnologyHunan Agricultural UniversityChangsha410128China Kuaijishan Shaoxing Rice Wine CO.Ltd.Shaoxing312030China China National Research Institute of Food and Fermentation IndustriesBeijing100015China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2020年第9卷第2期

页      面：184-191页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 0836[工学-生物工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 083203[工学-农产品加工及贮藏工程] 

基　　金：Double First-Class Construction Project of Hunan Agricultural University, (SYL201802025) Natural Science Foundation of Hunan Province Natural Science Foundation of Hunan Province 

主　　题：Yellow rice wine Aging Antioxidant Antifatigue Cognitive impairment Apoptosis 

摘      要：The present study is focused on investigation of the health protective effect of yellow rice wine(YRW)in mice and the potential underlying *** of aging were induced in mice by using Dgalactose(D-gal),and different doses of YRW(4,8,and 12 mL/kg BW)were orally administrated to D-galtreated mice for a period of six *** in vivo data obtained in the present study preliminary indicated that YRW markedly increased the activity of antioxidant enzymes and reduced the concentration of MDA both in the brain and ***,a forced swim test showed that moderate intake of YRW(8 mL/kg BW)significantly decreased the duration of immobility,reduced the blood content of urea nitrogen and lactic acid,and increased hepatic glycogen ***,results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and *** above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action.