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Understanding the rapid spread of antimicrobial resistance genes mediated by IS26

mLife 2024年第1期3卷 101-109页

作者： Na Tang Dawei Wei Yuan Zeng Gang Zhang Chao Wang Jie Feng Yuqin Song State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBejingChina College of Life Science University of Chinese Academy of SciencesBeijingChina

Insertion sequences(ISs)promote the transmission of antimicrobial resistance genes(ARGs)across bacterial ***,their contributions and dynamics during the transmission of resistance remain *** this study,we selected is26 as a representative transposable element to decipher the relationship between ISs and ARGs and to investigate their transfer features and transmission *** retrieved 2656 translocatable IS26-bounded units with ARGs(tiS26-bUs-ARGs)in complete bacterial genomes from the NCBI RefSeq *** total,124 ARGs spanning 12 classes of antibiotics were detected,and the average contribution rate of IS26 to these genes was 41.2%.We found that IS26-bounded units(IS26-bUs)mediated extensive ARG dissemination within the bacteria of the Gammaproteobacteria class,showing strong transfer po-tential between strains,species,and even *** Is26-bUs expanded in bacterial populations over time,and their temporal expansion trend was significantly correlated with antibiotic *** wide dissemination could be due to the nonspecific target site preference of ***,we experimentally confirmed that the introduction of a single copy of is26 could lead to the formation of a composite transposon mediating the transmission of“passenger”*** observations extend our knowledge of the IS26 and provide new insights into the mediating role of ISs in the dissemination of antibiotic resistance.

关键词： antibiotic consumption antibiotic resistance genes horizontal gene transfer insertion sequence IS26

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Correlation between a Change of Drug Resistance of <i>Klebsiella pneumonia</i>and Defined Daily Doses of Antimicrobial Agents from 2014 to 2018

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Pharmacology & Pharmacy 2020年第11期11卷 299-305页

作者： Jiuli Hu Xu Xiao Chanchan Hu Rui Wang Yanwu Zhao Xiaoqin Zhu Affiliated Hospital of ChengdeMedical University Chegnde Hebei China

Introduction: The prevalence of Klebsiella pneumoniae has rapidly increased in recent years and the distribution differed greatly by region, We aimed to study the relationship between antibiotic resistance and K. pneumoniae, especially carbapenem-resistant Klebsiella pneumoniae (CRKP) in our tertiary hospitals from 2014 to 2018. Methodology: The antibiotic consumption data of K. pneumoniae were expressed as the defined daily dose (DDD) per 100 inpatient days (DDDs). K. pneumoniae which isolated from clinical samples in hospital between January 2014 and December 2018 were retrospectively analyzed, and the correlation between antibiotic resistance rate and antibiotic frequency was analyzed. Results: From 2014 to 2018, a total of 2295 strains of K. pneumoniae were isolated, with the detection rates of 8.2%, 9.2%, 11.9%, 13.4% and 14.0%. There were 423 strains of CRKP, with the detection rates of 7.5%, 5.8%, 17.8% 24.2% and 25.2% respectively.

关键词： Klebsiella pneumonia antibiotic consumption Resistance Correlation Analysis Defined Daily Doses

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The Practice of Pharmacist-Driven Antimicrobial Stewardship Based on Value-Based Healthcare

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Asian Journal of Social Pharmacy 2021年第2期16卷 180-186页

作者： Sun Yinxiang Xu Chunhua Li Yong Huang Sichao Zhou Zhiling Cui Min Department of Clinical Pharmacy Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China School of Pharmacy Zunyi Medical UniversityZunyi 563000China Department of Hospital Affairs Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 19000China Department of Pharmacy Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University) Zhuhai 519000China

Objective To evaluate the effect of pharmacist-driven antimicrobial stewardship based on value-based healthcare in a tertiary hospital in *** The application of plan-do-check-action(PDCA)cycle and antimicrobial stewardship(AMS)were respectively used to improve the rational use of antimicrobial agents in prophylactic and *** were collected and the effect was assessed during the management period(2016-2019).Results and Conclusion From 2016(before implementation)to 2019(after implementation),the rational use of antibiotics were obviously enhanced in outpatients,inpatients,and emergency *** instance,the utilization rate in type I incision operation was decreased from 26.42%to 14.60%(P=0.000),the daily doses of antibiotic per 100 patient-days decreased from 49.34±2.97 to 35.89±4.96(P=0.000),and the average antibiotic expenditures dropped from 948.53 yuan to 526.30 yuan(P=0.000).There was no significant change in infection rate,nosocomial mortality rate,and the length of hospital *** the implementation of clinical pharmacist-driven antimicrobial stewardship based on value-based healthcare,the consumption and cost of antibacterial have been greatly ***,the pharmacist-driven antimicrobial stewardship increases its value。

关键词： pharmacist value-based healthcare antimicrobial stewardship antibiotic consumption medical quality

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