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中国化学会第27届学术年会

作者： David R Spring Department of Chemistry University of Cambridge

＜正＞The synthesis of structurally diverse and structurally complex collections of small molecules remains a major challenge to synthetic chemists. We illustrate the diversity-oriented synthesis

关键词： Diversity-Oriented Synthesis antibacterials Drug Discovery.

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Antibiotic Silver Particles Coated Graphene Oxide/polyurethane Nanocomposites Foams and Its Mechanical Properties

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Chinese Journal of Structural Chemistry 2022年第3期41卷 125-131,I0010页

作者：杨智李坤嵘张原野胡家乐李天源翁子骧吴立新 College of Chemistry Fuzhou UniversityFuzhou 350108China CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Key Lab for Sport Shoes Upper Materials of Fujian Province Fujian Huafeng New Material Co.Ltd.Putian 351164China

Silver nanoparticles(AgNPs)are widely adopted in polyurethane foams(PUFs)as a type of antibac-terial ***,due to its poor interfacial interaction,AgNPs are difficult to be dispersed in the polymer matrix uniformly,which deteriorates the enhancement *** this paper,silver-coated graphene nanocomposite(Ag/GO)is prepared by an enzyme reductant which is efficient and *** with traditional antibacterial agent,the Ag/GO nanoparticles can be uniformly dispersed in the nanocomposite,which means that Ag/GO can be well-dispersed into the polyurethane foams(PUFs).Compared with AgNPs modified PUFs,the as-prepared Ag/GO modi-fied PUFs have a 1.85%improvement in resilience,7.9%improvement in tensile strength,6.52%improvement in tensile elongation,and 8.74%improvement in bacteriostats rate at a loading of 0.4%.

关键词： graphene nanocomposite polyurethane foams antibacterials

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Studies on the cytocompatibility,mechanical and antimicrobial properties of 3D printed poly(methyl methacrylate)beads

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Bioactive Materials 2018年第2期3卷 157-166页

作者： David K.Mills Uday Jammalamadaka Karthik Tappa Jeffery Weisman Center for Biomedical Engineering and Rehabilitation Science USA The School of Biological Sciences Louisiana Tech UniversityRustonLA 71272USA

Osteomyelitis is typically a bacterial infection(usually from Staphylococcus)or,more rarely,a fungal infection of the *** can occur in any bone in the body,but it most often affects the long bones(leg and arm),vertebral(spine),and bones of the *** success in osteomyelitis is due to their ability to form biofilms which inhibit the wound healing process and increases resistance to anti-infective ***,biofilms do not allow easy penetration of antibiotics into their matrix making clinical treatment a *** development of local antibiotic delivery systems that deliver high concentrations of antibiotics to the affected site is an emerging area of research with great *** treatment includes antibiotic therapy,either locally or systemically and refractory cases of osteomyelitis may lead to surgical intervention and a prolonged course of antibiotic treatment involving placement of antibiotic-doped beads or spacers within the wound *** are disadvantages with this treatment modality including insufficient mixing of the antibiotic,lack of uniform bead size,resulting in lower antibiotic availability,and limitations on the antibiotics ***,a method is needed to address biofilm formations in the wound and on the surface of the surgical implants to prevent *** this study,we show that all antibiotics studied were successfully doped into PMMA and antibiotic-doped 3D printed beads,disks,and filaments were easily *** growth inhibition capacity of the antibiotic-loaded PMMA 3D printed constructs was also demonstrated.

关键词： 3D printing antibacterials Drug delivery Halloysite nanotubes Medical devices Nanotechnology

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