Studies on the cytocompatibility,mechanical and antimicrobial properties of 3D printed poly(methyl methacrylate)beads

作     者：David K.Mills Uday Jammalamadaka Karthik Tappa Jeffery Weisman 

作者机构：Center for Biomedical Engineering and Rehabilitation ScienceUSA The School of Biological SciencesLouisiana Tech UniversityRustonLA 71272USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2018年第3卷第2期

页      面：157-166页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：This work was partially funded by the Louisiana Governor's Biotechnology Initiative The Lagniappe Ladies Fund and a Louisiana Board of Regents Prototype/Proof-of-Concept grant 

主　　题：3D printing Antibacterials Drug delivery Halloysite nanotubes Medical devices Nanotechnology 

摘      要：Osteomyelitis is typically a bacterial infection(usually from Staphylococcus)or,more rarely,a fungal infection of the *** can occur in any bone in the body,but it most often affects the long bones(leg and arm),vertebral(spine),and bones of the *** success in osteomyelitis is due to their ability to form biofilms which inhibit the wound healing process and increases resistance to anti-infective ***,biofilms do not allow easy penetration of antibiotics into their matrix making clinical treatment a *** development of local antibiotic delivery systems that deliver high concentrations of antibiotics to the affected site is an emerging area of research with great *** treatment includes antibiotic therapy,either locally or systemically and refractory cases of osteomyelitis may lead to surgical intervention and a prolonged course of antibiotic treatment involving placement of antibiotic-doped beads or spacers within the wound *** are disadvantages with this treatment modality including insufficient mixing of the antibiotic,lack of uniform bead size,resulting in lower antibiotic availability,and limitations on the antibiotics ***,a method is needed to address biofilm formations in the wound and on the surface of the surgical implants to prevent *** this study,we show that all antibiotics studied were successfully doped into PMMA and antibiotic-doped 3D printed beads,disks,and filaments were easily *** growth inhibition capacity of the antibiotic-loaded PMMA 3D printed constructs was also demonstrated.