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Hemorrhagic Bartholin’s cyst in a woman using anti-platelet medication:A case report and review of the literature

World Journal of Clinical Cases 2023年第24期11卷 5755-5761页

作者： Yi-Rong Li Dah-Ching Ding Department of Obstetrics and Gynecology Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation and Tzu Chi UniversityHualien 970Taiwan

BACKGROUND We report the case of a postmenopausal female with a hemorrhagic Bartholin’s cyst who has been using an antiplatelet *** SUMMARY A postmenopausal woman,84 years of age,had a medical history of hypertension,diabetes mellitus,coronary artery disease(three-vessel disease),chronic kidney disease(stage 3),and *** patient has been taking clopidogrel,an antiplatelet medication,for several *** presented at our outpatient clinic complaining of painful swelling over her left vulva for several days.A Bartholin’s cyst over the left vulva was suspected,and the patient underwent marsupialization under local anesthesia,which was *** the incision procedure,bright-red blood with some blood clots was discharged,and a hemorrhagic Bartholin’s cyst was *** was no recurrence of the hemorrhagic Bartholin’s cyst during the 6-mo subsequent follow-up *** Hemorrhagic Bartholin’s cysts rarely *** report the case of a postmenopausal female with a hemorrhagic Bartholin’s cyst who had been on antiplatelets and was successfully treated with *** recurrence was noted during the 6-mo follow-up *** females taking antiplatelets should be cautious of bleeding when presenting with a Bartholin’s cyst.

关键词： Hemorrhagic Bartholin’s cyst anti-platelet Marsupialization Menopause Case report

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Inhibition of platelet Aggregation and In Vitro Free Radical Scavenging Activity of Dried Fruiting Bodies of Pleurotus eous

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Chinese Journal of Integrative Medicine 2015年第7期21卷 530-536页

作者： Suseem S.R Mary Saral Pharmaceutical Chemistry Division School of Advanced SciencesVIT University

Objective： To evaluate the ethyl acetate, methanol and aqueous extracts of dried fruiting bodies of Pleurotus eous for its anti-platelet activity on human volunteer＇s blood. And also to analyze the free radical scavenging property of the extracts of *** by using various in vitro models. Methods： anti-platelet activity of dried fruiting bodies of *** was evaluated by in vitro model using blood platelets. Inhibition of platelet aggregation was monitored after pre-incubation of platelets with the crude extracts of mushroom ***. antioxidant activities of extracts of *** were evaluated by different in vitro experiments, namely, 1, 1-diphenyl- 2-picryl hydrazyl （DPPH）, superoxide, hydroxyl radical and lipid peroxide radical models. Results： Crude extracts of mushroom *** inhibited platelet aggregation dose-dependently which was induced by adenosine diphosphate （ADP）. At a maximum concentration of 10 mg/mL, methanol extract effected 64.02% inhibition of lipid per-oxidation and 50.12% scavenging effect on superoxide anion radical. Aqueous extract of *** have shown 69.43% chelating ability on ferrous ions, 24.27% scavenging effect on hydroxyl radical and 49.57% scavenging effect on DPPH radical at 10 mg/mL. Increasing concentrations of the extract were found to cause progressively decreasing of the intensity of absorbance. Conclusions： anti-platelet effects could be related in part to the polyphenolic compounds present in the extracts. antioxidant activity results indicated the free radical scavenging property of the extracts of *** which might be due to the high content of phenolic compounds and flavonoids.

关键词： anti-platelet Pleurotus eous mushroom antioxidant scavenging effect chelating effect,reductive

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Influences of blood lipids on the occurrence and prognosis of hemorrhagic transformation after acute cerebral infarction: a case-control study of 732 patients

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Military Medical Research 2019年第3期6卷 189-200页

作者： Gang Lv Guo-Qiang Wang Zhen-Xi Xia Hai-Xia Wang Nan Liu Wei Wei Yong-Hua Huang Wei-Wei Zhang Department of General Surgery 309 Hospital of Chinese People’s Liberation ArmyBeijing 100091China Department of Neurology Chinese PLA Army General HospitalBeijing 100700China.

Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor ***: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 4

关键词： Acute cerebral infarction Hemorrhagic transformation Total cholesterol Low-density lipoprotein Intensive lipid-lowering statins anti-platelet Atrial fibrillation modified Rankin scale

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Adequate antiplatelet regimen in patients on chronic anti-vitamin K treatment undergoing percutaneous coronary intervention

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World Journal of Cardiology 2011年第11期3卷 367-373页

作者： Salvatore Brugaletta Victoria Martin-Yuste Ignacio Ferreira-González Clarissa Cola Luis Alvarez-Contreras Marta De Antonio Xavier Garcia-Moll Joan García-Picart Vicens Martí Jordi Balcells-Iranzo Manel Sabaté Thorax Institute Department of Car-diology Hospital Clinic Epidemiology Unit Department ofCardiology Vall d'Hebron Hospital Center of Epidemiology andPublic Heath Interventional Cardiology Unit University Hospital of Saint Paul Department of Cardiology University Hos-pital of Saint Paul

AIM: To investigate the impact of dual antiplatelet therapy (DAT) in patients on antivitamin K (AVK) regimen requiring percutaneous coronary intervention (PCI).METHODS: Between February 2006 and February 2008, 138 consecutive patients under chronic AVK treatment were enrolled in this registry. Of them, 122 received bare metal stent implantation and 16 received drug elutingstent implantation. The duration of DAT, on top of AVK treatment, was decided at the discretion of the clinician. Adequate duration of DAT was def ined according to type of stent implanted and to its clinical indication. RESULTS: The baseline clinical characteristics of patients reflect their high risk, with high incidence of comorbid conditions (Charlson score ≥ 3 in 89% of the patients). At a mean follow-up of 17 ± 11 mo, 22.9% of patients developed a major adverse cardiac event (MACE): 12.6% died from cardiovascular disease and almost 6% had an acute myocardial infarction. Major hemorrhagic events were observed in 7.4%. Adequate DAT was obtained in only 44% of patients. In the multivariate analysis, no adequate DAT and Charlson score were the only independent predictors of MACE (both P = 0.02). CONCLUSION: Patients on chronic AVK therapy represent a high risk population and suffer from a high MACE rate after PCI. An adequate DAT regimen and absence of comorbid conditions are strongly associated with better clinical outcomes.

关键词： Hemorrhagic risk anti-vitamin K treatment anti-platelet therapy Percutaneous coronary intervention

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Cardiac implications of thrombotic thrombocytopenic purpura

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World Journal of Cardiology 2018年第12期10卷 254-266页

作者： Szymon L Wiernek Bo Jiang Gregory M Gustafson Xuming Dai Division of Cardiology McAllister Heart Institute University of North Carolina at Chapel Hill Division of Cardiology Lang Research Center New York Presbyterian Medical Group–Queens Hospital

Thrombotic thrombocytopenic purpura(TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on plateletmediated micro-thrombi formation, leading to microvascular *** studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death. There is limited knowledge about optimal cardiac evaluation and management in patients with TTP. The absence of typical cardiac symptoms,combined with complicated multi-organ involvement in TTP, may contribute to the under-utilization of cardiac evaluation and treatment. Prompt diagnosis and timely initiation of effective therapy could be critically important in selected cases. Based on our experience and this review of the literature, we developed several recommendations for focused cardiac evaluation for patients with acute TTP:(1) patients with suspected or confirmed TTP should be screened for the potential presence of cardiac involvement with detailed history and physical,electrocardiogram and cardiac enzymes;(2) clinical deterioration of TTP patients warrants immediate cardiac reevaluation;(3) TTP patients with clinical evidence of cardiac involvement should be monitored for telemetry, cardiac biomarkers and evaluated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as well as cardiac-specific treatment. Aspirin therapy is indicated for all TTP patients. Since epicardial coronary artery involvement is rare, cardiac catheterization is usually not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical therapy for ischemic symptoms and heart failure. TTP patients with evidence of cardiac invol

关键词： Thrombotic thrombocytopenic purpura Acute myocardial infarction Coronary artery disease anti-platelet therapy von Willebrand factor ADAMTS13

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Pharmacological actions of miltirone in the modulation of platelet function

Pharmacological actions of miltirone in the modulation of pl...

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首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Ru-ping Yang Wei Song Zhang-yin Ming Department of Pharmacology School of Basic MedicineTongji Medical College of Huazhong University of Science and Technology

Salvia miltiorrhiza Bunge contains various active constituents,some of which have been developed as commercially available ***,some other ingredients in Salvia miltiorrhiza play roles in anti-platelet *** aim of the present study was to investigate the effects and the underlying mechanism of miltirone,a lipophilic compound of Salvia miltiorrhiza *** ability of miltirone to modulate platelet function was investigated by a variety of in vitro and in vivo *** aggregation and dense granule secretion induced by various agonists were measured with platelet *** retraction and spreading were imaged by digital camera and fluorescence *** chloride-induced carotid injury model and pulmonary thromboembolism model were used to check miltirone antithrombotic effect in *** elucidate the mechanisms of anti-platelet activity of miltirone,fl ow cytometry and western blotting were ***(2,4,8 μM) was shown to suppress platelet aggregation,dense granule,and a granule secretion in a dose-dependent ***,miltirone inhibited the clot retraction and spreading of washed *** reduced the phosphorylation of PLCγ2,PKC,Akt,GSK3β and ERK1/2 in the downstream signal pathway of collagen *** also reduced the phosphorylation of Src and FAK in the integrinαIIbβ3-mediated "outside-in" signaling,while it did not suppress the phosphorylation of β*** addition,miltirone prolonged the occlusion time and reduced collagen/epinephrine-induced pulmonary *** suppresses platelet"inside-out" and "outside-in" signaling by affecting PLCy2/PKC/ERK 1/2,PI3 K/Akt,and Src/FAK ***,miltirone might represent a potential anti-platelet candidate for the prevention of thrombotic disorders.

关键词： miltirone anti-platelet glycoprotein Ⅵ pathway integrin α Ⅱb β3

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Novel derivative of Danshensu acts as anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57

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中国药理学与毒理学杂志 2015年第S1期29卷 34-34页

作者： Guo-zhenCUI Lu-chenSHAN LinGUO IvanKeungCHU Guo-huiLI QuanQUAN YunZHAO Chenong-mengCHONG ZaijunZHANG PeiYU Pui-manHOI Ye-weiSUN Yu-qiangWANG Simonming-yuenLEE State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences University of Macao Macao China Institute of New Drug Research Collage of Pharmacy Jinan University Guangzhou China Key Laboratory of Cardiovascular Medicine Research Ministry of Education Harbin Medical University Harbin China Department of Chemistry University of Hong Kong Hong Kong Chian

OBJECTIVE To identify the specific targets of a novel derivative of Danshensu ADTM as the protein disulfide isomerase(PDI)family proteins including *** further investigate the underlying mechanism of ADTM to modulate ERp57 to regulate platelet function with direct interaction withαⅡbβ3 *** To isolate the protein targets that bound to ADTM,a biotin-conjugated ADTM analogue(BAA)was designed and ***(300μmol·L-1)was incubated with rat blood platelet lysates and the BAA-protein complexes were pulled down with NeutrAvidin-agarose followed by protein profiling using LC-MS/*** determine platelet aggregation in vitro,rabbit platelets were incubated with the indicated concentrations of compounds and aggregation was induced by ADP(10μmol·L-1)or AA(200μmol·L-1)and measured using a platelet *** determine platelet aggregation-induced by ADP in rat in vivo,ADTM(5-20mg·kg-1)in comparison with DSS(10mg·kg-1)and clopidogrel(18mg·kg-1)were administered daily by *** for 5d,*** determine the action of ADTM on the ERp57/αⅡbβ3 interaction,it was examined by immunoprecipitation with anti-αⅡbβ3antibody,followed by detection of ERp57 immunoreactivity using *** BAA could bind to various proteins involved in platelet *** particular,platelet aggregation-associated proteins were identified with>95% protein identification probability including ERp72,ERp57ERp5 and PDI,which are members of the protein disulfide isomerase(PDI)family related to platelet function and redox *** exhibited potent inhibition on the redox activity of ERp57 in a concentration-dependent manner(IC50=100 300μmol·L-1).In in vitro studies,ADTM exhibited concentration-dependent inhibition on ADP-induced and AA-induced platelet aggregation with comparable effects to aspirin and *** vivo study showed that ADP-induced platelet aggregation was significantly compromised(>40%reduction)in rats treated with ADTM(20mg·kg-1)

关键词： anti-platelet ERp57 Danshensu derivative ADTM

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