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Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease

Chinese Journal of Natural Medicines 2023年第9期21卷 643-657页

作者： LI Yanwei LU Yunrui NIAN Mozuo SHENG Qiuju ZHANG Chong HAN Chao DOU Xiaoguang DING Yang Department of Infectious Diseases Shengjing Hospital of China Medical UniversityShenyang 110000China Liaoning University of Traditional Chinese Medicine Shenyang 110000China

Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death *** the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment *** thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical *** are effective for liver fibrosis,though its mechanisms of action are *** recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver *** have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis *** this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic *** them,inhibition of stellate cell activation is identified as the most common *** article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness.

关键词： Chinese herbal medicine Liver fibrosis anti-hepatic fibrotic therapy Molecular mechanism Active ingredient

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