Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease

作     者：LI Yanwei LU Yunrui NIAN Mozuo SHENG Qiuju ZHANG Chong HAN Chao DOU Xiaoguang DING Yang LI Yanwei;LU Yunrui;NIAN Mozuo;SHENG Qiuju;ZHANG Chong;HAN Chao;DOU Xiaoguang;DING Yang

作者机构：Department of Infectious DiseasesShengjing Hospital of China Medical UniversityShenyang 110000China Liaoning University of Traditional Chinese MedicineShenyang 110000China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2023年第21卷第9期

页      面：643-657页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Liaoning Provincial Local Professional Technology Innovation Platform Construction Project(2016007013) Liaoning Provincial Natural Science Foundation(2014021007) Outstanding Scientiffc Fund of Shengjing Hospital(2011-02) 345 Talent Project of Shengjing Hospital(2020-01) The Mechanism of Immune Tolerance Mediated by Myeloid-Derived Suppressor Cells inhibiting T Cell Immune Responses via PD-L1 in Chronic Hepatits B(2022-12) 

主　　题：Chinese herbal medicine Liver fibrosis Anti-hepatic fibrotic therapy Molecular mechanism Active ingredient 

摘      要：Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death *** the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment *** thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical *** are effective for liver fibrosis,though its mechanisms of action are *** recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver *** have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis *** this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic *** them,inhibition of stellate cell activation is identified as the most common *** article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness.