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病毒防护产品—Sophos anti-virus

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信息安全与通信保密 2003年第12期25卷 72-72页

由Sophos公司推出的防毒产品Sophos anti-virus中文版,以集成的方式在服务器、台式机和笔记本上进行跨平台的病毒查杀工作,且在数据同步过程中可对移动设备提供保护。该产品具有自动、定时。

关键词： Sophos公司 anti-virus 防毒软件产品功能

感受AVG anti-virus System的免费大餐

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网上俱乐部（电脑安全专家） 2004年第11期 75-75页

作者：飘雪

虽说天下没有免费的午餐，但最近笔者却发现了一款功能强大的免费杀毒软件——AVG anti-virvs system free edition.

关键词：杀毒软件 AVG anti-virus System 工具软件计算机病毒

Indole alkaloid glycosides with a 1′-(phenyl)ethyl unit from Isatis indigotica leaves

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Acta Pharmaceutica Sinica B 2020年第5期10卷 895-902页

作者： Qinglan Guo Dawei Li Chengbo Xu Chenggen Zhu Ying Guo Haibo Yu Xiaoliang Wang Jiangong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Seven indole alkaloid glycosides containing a 1′-(4″-hydroxy-3″,5″-dimethoxyphenyl)ethyl unit(1-7)were isolated from an aqueous extract of Isatis indigotica leaves(da qing ye).Their structures were determined by spectroscopic data analysis combined with enzymatic hydrolysis as well as comparison of their experimental CD(circular dichroism)and calculated ECD(electrostatic circular dichroism)*** on analysis of[α]D20 and/or Cotton effect(CE)data of 1-7,two simple roles to assign location and/or configuration ofβ-glycopyranosyloxy and 1′-(phenyl)ethyl units in the indole alkaloid glycosides are *** in plausible biosynthetic pathways of 1-7 is *** 3 and 4 and their mixture in a 3:2 ratio showed activity against KCNQ2 in CHO *** mixture of 5 and 6(3:2)exhibited antiviral activity against influenza virus H1 N1 PR8 with IC5064.7μmol/L(ribavirin,IC5054.3μmol/L),however,the individual 5 or 6 was *** structure-activity relationships were observed.

关键词： Cruciferae Isatis indigotica Indole alkaloid glycoside Isatidifoliumosides Epiisatidifoliumosides KCNQ2 inhibition anti-infuenza anti-virus Activity

Multiple biological functions and pharmacological effects of lycorine

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Science China Chemistry 2013年第10期56卷 1382-1391页

作者： CAO ZhiFei YANG Ping ZHOU QuanSheng Cyrus Tang Hematology Center Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Key Laboratory of Thrombosis and Hemostasis Ministry of Health Soochow University

Lycorine is the major active component from the amaryllidaceae family plant Lycoris radiate,a represent traditional Chinese medicinal herb,and is one of the typical alkaloids with pyrrolophenanthridine nucleus *** has drawn great interest in medicinal field due to its divergent chemical structures and multiple biological functions,as well as pharmacological effects on various *** evidence shows that lycorine not only possesses strong pharmacological effects on many diseases,including anti-leukemia,anti-tumor,anti-angiogenesis,anti-virus,anti-bacteria,anti-inflammation,and anti-malaria,but also exerts many other biological functions,such as inhibition of acetylcholinesterase and topoisomerase,suppression of ascorbic acid biosynthesis,and control of circadian period ***,lycorine exhibits its numerous pharmacological effects on various diseases with very low toxicity and mild side *** divergent chemical structures,multiple biological functions,and very low toxicity of lycorine imply that the agent is a potential drug candidate that warrants for further preclinical and clinic investigation.

关键词： traditional Chinese medicinal herbs lycorine anti-cancer anti-virus angiogenesis neovascularization

Unraveling the Mystery of γδ T Cell Recognizing Lipid A

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Cellular & Molecular Immunology 2005年第5期2卷 359-364页

作者： Yongchun Cui Lianxian Cui Wei He Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences ＆ School of Basic Medicine Peking Union Medical College Beijing 100005 China Corresponding to： Dr. Wei He Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences 5 Dong Dan San Tiao Beijing 100005 China

Traditionally, the materials which are regarded as antigens recognized by γδ T lymphocytes are protein and carbohydrate, not nucleic acid or lipid. Recently, it has been demonstrated that γδ T cells can recognize lipid A and directly induce immune responses that involve CD1 （cluster of differentiation type 1） family and Toll like receptors （TLRs）. This is a review about the interacting-mechanism, immunological effect and clinical application of them.

关键词： CD 1 TLR anti-bacterial anti-tumor anti-virus

anti-viral Effects of Urosolic Acid on Guinea Pig Cytomegalovirus In Vitro

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第6期32卷 883-887页

作者：赵晶晶陈娟娟刘涛方建国万进赵建华李伟刘静赵贤哲陈素华 Department of Obstetrics and Gynecology Affiliated Hospital of Hebei University of Engineering Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Pharmacy Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

This study examined the anti-viral effect of ursolic acid on guinea pig cytomegalovirus (GPCMV) and explored the steps of viral replication targeted by ursolic acid. Cytopathic effect assay and MTT method were employed to determine the 50% cellular cytotoxicity (CC50), 50% effective concentration (EC50) and therapeutic index (TI) with GPCMV. To investigate the specific anti-viral effect of ursolic acid at different temperatures and time points, two other medicines, ganciclovir and Jinyebaidu (JYBD), serving as controls, were studied for comparison. Our results showed that the CC50 of ganciclovir, JYBD and ursolic acid were 333.8, 3015.6, 86.7 μg/mL, respectively; EC50 of ganciclovir, JYBD and ursolic acid was 48.1, 325.5 and 6.8 μg/mL, respectively; TI of ganciclovir, JYBD and ursolic acid was 7, 9, 13, respectively. Similar with ganciclovir, ursolic acid could inhibit the viral synthesis, but did not affect the viral adsorption onto and penetration into cells. We are led to conclude that the anti-cytomegalovirus effect of ursolic acid is significantly stronger than ganciclovir or JYBD, and the cytotoxic effect of ursolic acid lies in its ability to inhibit viral synthesis.

关键词： ursolic acid anti-virus cytopathic effect

anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

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Natural Products and Bioprospecting 2021年第1期11卷 127-135页

作者： Yun-Li Zhao Zhong-Ping Gou Jian-Hua Shang Wan-Yi Li Yu Kuang Ming-Yuan Li Xiao-Dong Luo State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Provincial Center for Research&Development of Natural ProductsSchool of Chemical Science and TechnologyYunnan UniversityKunming 650091P.R.China Institute of Drug Clinical Trials West China HospitalSichuan UniversityChengdu 610041China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041China

Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory,which might be caused by respiratory tract *** investigation tested the anti-infective effects of total alkaloids extract(TA)from leaves of ***,and as a result,TA inhibited herpes simplex virus type 1(HSV-1),respiratory syncytial virus(RSV)and influenza A virus(H1N1)in vitro *** addition,the survival days of mice were prolonged,and the lung weights and mortality of mice were decreased significantly,after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo *** finding supported partly the traditional usage of *** in the treatment of respiratory infections.

关键词： Alstonia scholaris Total alkaloids Acute respiratory infections anti-virus anti-bacteria

Fermented Herbal Decoction Selectively Targeting Human Cancer Cell Line and Human Pathogenic Microorganism

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Open Journal of Rheumatology and Autoimmune Diseases 2018年第1期8卷 17-33页

作者： Nobuo Yamaguchi Nurmuhammat Amat Kazuhiro Okamoto Tsugiya Murayama Ishikawa Natural Medicinal Product Research Center Kawakawa Japan Traditional Uyghur Medicine Institute Xingjian Medical University Urumqi China Department of Rehabilitation Kanazawa Medical University Uchinada Japan Department of Microbiology and Immunology Faculty of Pharmaceutical Sciences Hokuriku University Kanazawa Japan

Introduction: Prolonged immuno-suppressed status promised to induce internal growth of malignant cell and infectious agent, yet, only a small part of affected individuals seek medical attention or berried by commercially over-flowed fake information. Several studies have described complementary and alternative medicine as effective strategies for improving anti-infectious agent including malignant cell. The purpose of this study was to investigate the effect of a fermented herbal decoction (FHD) both in vitro and in vivo to malignant cells and microorganism by regulating leukocyte subset proportioning FHD as dietary material. Methods: In this approach of alternative study, selective anti-cancer effect by fermented decoction was tried to show first in vitro system both, cancer cell and virus strain. The fermented herbal decoction consisting of 80 sorts of herbs and fruits. The selective toxicity was set up and then for immunological factors in animal and human. The most important factor is to reduce side effect for a normal cell. Results: First, FHD was proved as safe by animal test. FHD regulated also the proportion of granulocyte and lymphocyte ratio both animal and human. In vitro culture showed selective toxicity by FHD against human melanoma and leukemia cell line but reduced toxicity was showed by normal cell line. As for the anti-virus activity, anti-virus effect was tested on the feeder layer of human fibroblast cell, after 9 days of culture. Second, FHD inhibits colon cancer growth in 3-methylholanthrene induced cancer in rat. Conclusion: The present results suggest that our fermented herbal decoction showed selective anti-cancer activities and anti-virus activities, together with the regulative effect on the immune system.

关键词： Fermented Herbal Decoction Human Malignant Cell Line Human Normal Cell Line anti-virus Activity 3-Methylholanthrene Experimental Colon Can-cer In Vitro In Vivo anti-Cancer Trial

Research Progress on Pharmacological Effects of Shikonin Compound β-acetoxyisovalerylalkannin

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Medicinal Plant 2022年第2期13卷 1-3,7页

作者： Anqi WANG Chenghao JIN College of Life Science and Biotechnology Heilongjiang Bayi Agricultural University Daqing 163319 China

Shikonin compoundβ-acetoxyisovalerylalkannin is a kind of high fat-soluble naphthoquinone pigment,which can exert its pharmacological effects including anticancer,anti-inflammatory,bacteriostatic and antiviral effects in many *** this paper,the pharmacological effects and mechanism ofβ-acetoxyisovalerylalkannin are reviewed in order to provide theoretical basis for the clinical application ofβ-acetoxyisovalerylalkannin.

关键词： β-acetoxyisovalerylalkannin anticancer anti-inflammation Bacteriostasis anti-virus