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PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

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Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang Jingjing Duan Yalu Tan Panlin Liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang Yan Huang Yangzhou Zhang Jia-Da Li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as LIMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton animal behavior

Dispersal patterns of Reeves's pheasant based on genetic and behavioral evidence

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Current Zoology 2024年第4期70卷 480-487页

作者： Shuai Lu Xian Hou Shan Tian Zhengxiao Liu Yunqi Wang Ting Jin Jianqiang Li Pengcheng Wang Jiliang Xu School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China State Key Laboratory of Efficient Production of Forest Resources Bejing Forestry UniversityBeijing 100083China Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjing 210o23China

Dispersal is an important life history trait that plays a crucial role in avoiding *** the dispersal pattern of a threatened species facilitates conservation *** species of Galliformes are forest-dwelling terrestrial birds with a weak dispersal ability and high conservation ***,little is known about the dispersal behavior and dispersal pattern of Galliformes species such as Reeves's pheasant Syrmaticus reevesi,a globally vulnerable species endemic to ***,we integrated behavioral and genetic analyses to inves-tigate the dispersal pattern of Reeves's *** results revealed that both females and males would disperse,although the overall dispersal pattern was more likely to be ***'s pheasant population had a low level of genetic diversity and a mild level of *** low genetic diversity was resulted from fragmented habitat,and male-biased dispersal may reduce the opportunity of *** research indicated that sex-biased dispersal patterns may be a behavioral mechanism adopted by wildlife to avoid inbreeding inafragmented habitat.

关键词： animal behavior dispersal Gallformes genetic diversity satellite tracking.

Contextual influences on animal decision-making:Significance for behavior-based wildlife conservation and management

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Integrative Zoology 2017年第1期12卷 32-48页

作者： Megan A.OWEN Ronald R.SWAISGOOD Daniel T.BLUMSTEIN Institute for Conservation Research San Diego Zoo GlobalSan DiegoCaliforniaUSA Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCaliforniaUSA

Survival and successful reproduction require animals to make critical decisions amidst a naturally dynamic environmental and social background(i.e.“context”).However,human activities have pervasively,and rapidly,extended contextual variation into evolutionarily novel territory,potentially rendering evolved animal decision-making mechanisms and strategies *** suggest that explicitly focusing on animal decision-making(ADM),by integrating and applying findings from studies of sensory ecology,cognitive psychology,behavioral economics and eco-evolutionary strategies,may enhance our understanding of,and our ability to predict how,human-driven changes in the environment and population demography will influence animal ***,the decisions animals make involve evolved mechanisms,and behaviors emerge from the combined action of sensory integration,cognitive mechanisms and strategic rules of thumb,and any of these processes may have a disproportionate influence on *** there is extensive literature exploring ADM,it generally reflects a canalized,discipline-specific approach that lacks a unified conceptual *** a result,there has been limited application of ADM theory and research findings into predictive models that can enhance management outcomes,even though it is likely that the relative resilience of species to rapid environmental change is fundamentally a result of how ADM is linked to contextual ***,we focus on how context influences ADM,and highlight ideas and results that may be most applicable to conservation biology.

关键词： animal behavior anthropogenic change context decision-making wildlife management

Establishment of a rat model of severe spontaneous intracerebral hemorrhage

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Journal of Intensive Medicine 2024年第1期4卷 108-117页

作者： Shuixiang Deng Shengjie Feng Yuewen Xin Yu He Yao Wang Mi Tian Ye Gong Department of Critical Care Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiChina

Background:Severe intracerebral hemorrhage(ICH)is the most devastating subtype of stroke resulting in high mortality and *** present,the development of targeted treatments to minimize the high morbidity and mortality is limited partly due to the lack of a severe ICH animal *** this study,we aimed to establish an accurate severe ICH model in rats and examine the pathological and physiological changes associated with ***:A rat model of severe ICH model was established by intrastriatal injection of autologous blood using different blood volumes(ICH 100μL group,ICH 130μL group,ICH 160μL group,ICH 170μL group,and ICH 180μL group).The mortality was assessed during the 28-day post-ICH ***-and long-term neurological deficits were evaluated using the Longa method,foot fault,falling latency,and Morris water maze *** water content,hematoma volume,hemoglobin content,and magnetic resonance imaging were assessed to determine the extent of brain *** staining was conducted to examine microglial activation and neuronal *** and eosin(H&E)staining,lung water content,and western blotting were used to assess lung injury following ***:The mortality of ICH rats increased significantly with an increase in autologous blood *** 28-day mortality in the 100μL,130μL,160μL,170μL,and 180μL ICH groups were 5%,20%,40%,75%,and 100%,respectively.A significantly higher 28-day mortality was observed in the ICH 160μL group compared to the ICH 100μL *** ICH 160μL group exhibited significantly increased neurological deficits,brain edema,hematoma volume,and hemoglobin content compared to the sham *** with the sham operation group,the activation of microglia and neuronal death in ICH 160μL rats *** use of H&E staining and western blotting demonstrated that disruption of the intra-alveolar structure,alveolar edema,and infiltration of inflammatory cells and cytokines into the lung tissu

关键词： Severe spontaneous intracerebral hemorrhage animal model Autologous blood injection animal behavior Lung injury

Use of 3D-printed animal models as a standard method to test avian behavioral responses toward nest intruders in the studies of avian brood parasitism

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Avian Research 2022年第4期13卷 487-490页

作者： Xiangyang Chen Yan Cai Jiaojiao Wang Canchao Yang Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life SciencesHainan Normal UniversityHaikou571158China

Living and/or non-living animal models are often used as stimuli to observe the behavioral responses of the target *** the past,parasites,predators,and harmless controls have been used to test host anti-parasitism defense behavior,and their taxidermy specimens have been widely used as a set of standard methods for the study of avian brood *** recent years,with the rapid development of 3D-printing technology,3D-printed bird models are expected to be applied as a standard method in the study of avian brood *** evaluate the use of 3D-printed models,this study tests the reaction of Oriental Reed Warbler(Acrocephalus orientalis)towards predators,parasites,or controls,and compares the reaction among different nest intruders and between taxidermy specimens and 3D-printed animal *** was found that the Oriental Reed Warbler responded most aggressively to the parasite,followed by predator,and finally the control;the results were consistent between the reaction to taxidermy specimens and 3D-printed animal models,indicating that 3D-printed models could serve as a substitute for taxidermy *** propose a series of advantages of using 3D-printed models and suggest them to be a standard method for widespread use in future studies of avian brood parasitism.

关键词： animal behavior Cuckoo parasitism Taxidermy specimens 3D-printed technology

Function of Ca^(2+)-/calmodulin-dependent protein kinase Ⅳ in Ca^(2+)-stimulated neuronal signaling and behavior

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Science China(Life Sciences) 2015年第1期58卷 6-13页

作者： SONG ZiXiang CHEN Qi DING Qi ZHENG Fei LI ChengWei XU LePing WANG HongBing Department of Adolescent Psychiatry and behavioral Therapy Heping Hospital Changzhou Department of Physiology Michigan State University Department of Biochemistry and Molecular Biology Michigan State University College of Life Science and Agronomy Zhoukou Normal University Neuroscience Program Michigan State University

The activity of Ca2+/calmodulin-dependent protein kinase IV(Ca MKIV) is sensitive to activity-dependent changes in the level of intracellular Ca2+.Following neuronal stimulation,the activation of Ca MKIV may trigger synaptic modifications and transcriptional responses,both of which are involved in regulating cognitive and emotional ***,we used Ca MKIV knockout(KO) neurons and mice to examine the function of Ca MKIV in Ca2+-stimulated intracellular signaling and animal behavior,*** NMDA receptor activation or membrane depolarization,the up-regulation of CREB(c AMP responsive element binding protein) and its target gene Bdnf(brain-derived neurotrophic factor) was intact in cortical neurons obtained from Ca MKIV KO *** MKIV KO mice displayed severe impairment in contextual fear memory but normal locomotor activity and anxiety level in the contextual training *** Ca MKIV KO mice showed normal memory in the standard passive avoidance task,they were defective in learning the temporal dissociative passive avoidance *** indicated by the light/dark test and marble-burying test data,Ca MKIV KO mice showed less anxiety and normal *** the voluntary wheel-running test,Ca MKIV KO mice showed normal running time and distance but higher maximal running *** results demonstrate the function of Ca MKIV in regulating different forms of fear memory,anxiety,and certain aspect of motor function.

关键词： animal behavior calmodulin CREB ERK1/2 intracellular signaling learning and memory

Effects of different feeding methods and space allowance on the growth performance, individual and social behaviors of Holstein calves

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Journal of Integrative Agriculture 2017年第6期16卷 1375-1382页

作者： DONG Li-feng XU Xian-cha ZHANG Nai-feng TU Yan DIAO Qi-yu Feed Research Institute Chinese Academy of Agricultural Sciences/Key Laboratory of Feed Biotechnology Ministry of Agriculture Beijing 100081 P.R. China

The importance of nutrient provisions and weaning methods for calves has been well established over the past few years,while as increasing interest has focused on contribution of animal behavior and their overall performance in production *** present study investigated the effects of feeding methods and space allowance on growth performance,individual and social behaviors in Holstein ***-four Chinese Holstein male and female calves were allocated to either an individual or group of 6 and fed either with a bucket or a *** replacer,calf starter,and Chinese wildrye were offered during the experiment.A fecal index used in the present study was defined as the total fecal scores/total number of calves in each *** results showed that there was no significant difference among the 4 treatments in terms of feed intake,body weight,average daily gain,and fecal *** the feeding behaviors,the ingesting milk time and ingesting milk rate were significantly affected by space allowance,while the feeding methods showed a significant influence on the bunting behavior of the *** was no significant difference among the 4 treatments in terms of licking fixtures,self-grooming,and lying down behaviors,irrespective of the feeding method or space ***,sucking an empty bucket or the teat was significantly affected by the feeding *** selected group behaviors were examined in the present study,and similar values for sniffing the other calves,social grooming,and cross-sucking behaviors were ***,the present study demonstrated that different feeding methods and space allowances had a significant effect on the feeding behavior of calves,while the feed intake,growth performance,health condition,individual and group social behaviors were not significantly ***,under intensified production systems,Holstein calves raised in a group may obtain a similar production performance,thus reducing management in

关键词： dairy calves feeding approach space allowance growth performance animal behavior

Integrative behavioral ecotoxicology： bringing together fields to establish new insight to behavioral ecology, toxicology, and conservation

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Current Zoology 2017年第2期63卷 185-194页

作者： Elizabeth K. PETERSON David B. BUCHWALTER Jacob L. KERBY Matthew K. LEFAUVE Claire W. VARIAN-RAMOS John R SWADDLE Department of Biological Sciences State University of New York-Albany Albany NY 12222 USA Department of Biological Sciences North Carolina State University Raleigh NC 27695 USA Department of Biology University of South Dakota Vermillion SD 57069 USA Department of Biological Sciences George Washington University Washington DC 20052 USA Department of Biology Colorado State University-Pueblo Pueblo CO 81001 USA Biology Department Institute for Integrative Bird Behavior Studies College of William & Mary Williamsburg VA 23187-8795 USA

The fields of behavioral ecology, conservation science, and environmental toxicology individually aim to protect and manage the conservation of wildlife in response to anthropogenic stressors, including widespread anthropogenic pollution. Although great emphasis in the field of toxicology has been placed on understanding how single pollutants affect survival, a comprehensive, interdis- ciplinary approach that includes behavioral ecology is essential to address how anthropogenic compounds are a risk for the survival of species and populations in an increasingly polluted world. We provide an integrative framework for behavioral ecotoxicology using Tinbergen＇s four postu- lates （causation and mechanism, development and ontogeny, function and fitness, and evolution- ary history and phylogenetic patterns）. The aims of this review are： 1） to promote an integrative view and re-define the field of integrative behavioral ecotoxicology; 2） to demonstrate how study- ing ecotoxicology can promote behavior research; and 3） to identify areas of behavioral ecotoxicol- ogy that require further attention to promote the integration and growth of the field.

关键词： animal behavior behavioral ecology conservation phylogenetic pollution toxicology.