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Exercise as a therapy for cancer-induced muscle wasting

Sports Medicine and Health Science 2020年第4期2卷 186-194页

作者： Jessica L.Halle Brittany R.Counts James A.Carson Integrative Muscle Biology Laboratory Division of Rehabilitation SciencesCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Cancer cachexia is a progressive disorder characterized by body weight,fat,and muscle *** induces metabolic disruptions that can be analogous and distinct from those observed in cancer,obscuring both diagnosis and treatment ***,hypogonadism,and physical inactivity are widely investigated as systemic mediators of cancer-induced muscle *** the cellular level,dysregulation of protein turnover and energy metabolism can negatively impact muscle mass and *** is well known for its anti-inflammatory effects and potent stimulation of anabolic *** evidence suggests the potential for exercise to rescue muscle's sensitivity to anabolic stimuli,reduce wasting through protein synthesis modulation,myokine release,and subsequent downregulation of proteolytic *** date,there is no recommendation for exercise in the management of *** its complex nature,a multimodal approach incorporating exercise offers promising potential for cancer cachexia *** review's primary objective is to summarize the growing body of research examining exercise regulation of cancer ***,we will provide evidence for exercise interactions with established systemic and cellular regulators of cancer-induced muscle wasting.

关键词： Physical activity anabolic resistance Inflammation IL-6 Metabolic dysfunction Protein turnover

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Effects of Neuromuscular Electrical Stimulation in Combination with Glutamine Administration on Skeletal Muscle Atrophy in Colon-26 Tumor-Bearing Mice

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Proceedings of Anticancer Research 2023年第6期7卷 21-32页

作者： Daisuke Tatebayashi Koichi Himori Yuki Ashida Takashi Yamada Graduate School of Health Sciences Sapporo Medical UniversitySapporoHokkaido 060-8556Japan

The depressed protein synthetic response,a phenomenon termed anabolic resistance,has been shown to be involved in muscle wasting induced by cancer ***,a positive relationship between the protein synthetic rate and intracellular glutamine(GLN)concentration has been found in skeletal *** study investigated the effects of neuromuscular electrical stimulation(ES)and GLN administration on muscle wasting and GLN metabolism in colon-26(C-26)tumor-bearing ***2F1 mice were divided into 8 groups:control(CNT),CNT+ES,CNT+GLN,CNT+ES+GLN,C-26,C-26+ES,C-26+GLN,C-26+ES+*** cachexia was induced by subcutaneous injection of C-26 cells and developed for four *** was performed on the left plantar flexor muscles every other day,and GLN(1 g/kg)was administered daily intraperitoneally starting one day after the C-26 ***-free body mass and fast-twitch gastrocnemius(Gas)muscle weight were lower in the C-26 group than in the CNT group(-19%and-17%,respectively).Neither ES training nor GLN administration,alone or in combination,ameliorated the loss of Gas muscle weight in the C-26 ***,ES training in combination with GLN administration inhibited the increased expression of GLN synthetase(GS)in the C-26 ***,it is likely that GLN plays a critical role in muscle protein metabolism and,therefore,can be targeted as a tentative treatment of cancer cachexia.

关键词： Cancer cachexia anabolic resistance Muscle atrophy Glutamine Neuromuscular electrical stimulation

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