Exercise as a therapy for cancer-induced muscle wasting
作者机构：Integrative Muscle Biology LaboratoryDivision of Rehabilitation SciencesCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA
出 版 物：《Sports Medicine and Health Science》 (运动医学与健康科学（英文）)
年 卷 期：2020年第2卷第4期
页 面：186-194页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Physical activity Anabolic resistance Inflammation IL-6 Metabolic dysfunction Protein turnover
摘 要：Cancer cachexia is a progressive disorder characterized by body weight,fat,and muscle *** induces metabolic disruptions that can be analogous and distinct from those observed in cancer,obscuring both diagnosis and treatment ***,hypogonadism,and physical inactivity are widely investigated as systemic mediators of cancer-induced muscle *** the cellular level,dysregulation of protein turnover and energy metabolism can negatively impact muscle mass and *** is well known for its anti-inflammatory effects and potent stimulation of anabolic *** evidence suggests the potential for exercise to rescue muscle s sensitivity to anabolic stimuli,reduce wasting through protein synthesis modulation,myokine release,and subsequent downregulation of proteolytic *** date,there is no recommendation for exercise in the management of *** its complex nature,a multimodal approach incorporating exercise offers promising potential for cancer cachexia *** review s primary objective is to summarize the growing body of research examining exercise regulation of cancer ***,we will provide evidence for exercise interactions with established systemic and cellular regulators of cancer-induced muscle wasting.
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