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STUDIES ON SELF-ASSOCIATIVE BEHAVIOR OF A NOVEL CATION amphiphilic polymer

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Chinese Journal of polymer Science 2009年第4期27卷 593-596页

作者：吴飞鹏 Technical Institute of Physics and Chemistry Chinese Academy of Sciences

A novel associating polymer P(AEBA) was synthesized by radical polymerization of the cationic amphiphilic monomer,4-(2-(acryloyloxy)ethoxy)benzyl tri-ethyl ammonium bromide(AEBA),in aqueous solutions.P(AEBA) displays a strong tendency for self-association in aqueous solutions and is sensitive to the external stimulation such as added *** associative properties and morphologies of P(AEBA) were studied by fluorescnece probe technique,viscometry and *** dilute salt-free solutions P(AEBA) behaves as pol...

关键词： amphiphilic polymer Self-association Aggregation structure

Stability of the Oil-water Emulsion Formed During amphiphilic polymer Flooding

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Stability of the Oil-water Emulsion Formed During Amphiphili...

Controlled Self-assembly of Thermo-responsive amphiphilic H-shaped polymer for Adjustable Drug Release

中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： J.Qiu Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of Sciences

The amphiphilic polymer can greatly improve the stability of produced liquid and thus makes it difficult to *** is of great necessity to study the stability of amphiphilic polymer flooding O/W crude oil emulsion.O/W crude oil emulsion tends to be more stable with increasing amphiphilic polymer concentration and decreasing holding *** polymer flooding O/W crude oil emulsion is much more stable,especially when polymer concentration is above critical aggregation *** formed by hydrophobic groups of the amphiphilic polymer is beneficial to the stability of amphiphilic polymer flooding O/W crude oil emulsions.

关键词： aggregation amphiphilic polymer CAC O/W emulsion stability

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Chinese Journal of polymer Science 2018年第3期36卷 406-416页

作者： Yang Bai Fang-Yuan Xie Wei Tian College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi'an 710021China Ministry of Education Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions and Shaanxi Key Laboratory of Macromolecular Science and Technology School of ScienceNorthwestern Polytechnical UniversityXi’an 710072China Department of Pharmacy Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200438 China

Despite the fact that some progress has been made in the self-assembly of H-shaped polymers, the corresponding self-assemblies that respond to external stimulus and are further utilized to adjust the release of drugs are still deficient. The stimuli-responsive segments with amphiphilic H-shaped structure are generally expected to enhance the controllability of self-assembly process. The synthesis and self-assembly behavior of thermo-responsive amphiphilic H-shaped polymers with poly（ethylene glycol）（PEG）, polytetrahydrofuran （PTHF） and poly（N-isopropyl acrylamide）（PNIPAM） as building blocks are reported in this paper. The inner architecture structure and size of complex micelles formed by H-shaped self-assemblies were effectively adjusted when the solution temperature was increased above the lower critical solution temperature of PNIPAM segments. Furthermore, it was found that the architecture of self-assemblies underwent a transition from the complex micelles based on primary micelles with hybrid PEG/PNIPAM shells to large complex micelles based on primary micelles with hybrid PTHF/PNIPAM cores and PEG shells during the thermal-induced self-assembly process. The adjustable release rate ofdoxorubicin （DOX） from the DOX-loaded complex micelles and basic cell experiments further proved the feasibility of these self-assemblies as the thermal-responsive drug delivery system.

关键词： H-shaped polymer Thermo-responsive polymer amphiphilic polymer Self-assembly Drug release

Folate-conjugated pH-responsive nanocarrier designed for active tumor targeting and controlled release of doxorubicin

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Frontiers of Materials Science 2017年第4期11卷 328-343页

作者： Lulu WEI Beibei LU Lin CUI Xueying PENG Jianning wu Deqiang LI Zhiyong LIU Xuhong GUO School of Chemistry & Chemical Engineering Shihezi University/Key Laboratory of Green Processing for Chemical Engineering/Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region/Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan Shihezi 832003 China School of Medicine Shihezi University Shihezi 832003 China College of Chemistry and Chemical Engineering Xinjiang Agricultural University Urumqi 830001 China State Key Laboratory of Chemical Engineering East China Universityof Science and Technologyl Shanghai 200237 China

A novel type of amphiphilic pH-responsive folate-poly（ε-caprolactone）- block-poly（ 2-hydroxyethylmethacrylate ）-co-poly（ 2-（ dimethylamino ）-ethylmethacrylate ）（FA-PCL-b-P（HEMA-co-DMAEMA））（MFP） block copolymers were designed and synthe- sized via atom transfer radical polymerization （ATRP） and ring opening polymerization （ROP） techniques. The molecular structures of the copolymers were confirmed with IH NMR, FTIR and GPC measurements. The critical micelle concentration （CMC） of MFP in aqueous solution was extremely low （about 6.54 mglL）. The in vitro release behavior of DOX-Ioaded micelles was significantly accelerated when the pH value of solution decreased from 7.4 to 5.0. In vitro antitumor efficiency was evaluated by incubating DOX- loaded micelles with Hela cells. The results demonstrated that this copolymer possessed excellent biocompatibility, and FA-decorated micelles MFP showed higher cellular uptake than those micelles without the FA moiety, indicating their unique targetability. These folate-conjugated biodegradable micelles are highly promising for targeted cancer chemothe-rapy.

关键词： amphiphilic polymer pH-sensitive active targeting drug delivery system folic acid

SYNTHESIS OF POLYBUTADIENE MACROINITIATOR AND POLYBUTADIENE/POLYACRYLAMIDE BLOCK COpolymerS

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Chinese Journal of polymer Science 1995年第3期13卷 244-251页

作者：方天如王家行方政刘沛妍 Changchun Institute of Applied Chemistry Academia Sinica Changchun 130022 Department of Chemistry The Northeast Normal University Changchun 130024

An azo-group containing polybutadiene macroinitiator was prepared by Pinner synthesis and characterized by IR, NMR, GPC, viscosity and elemental measurements. The macroinitiator was further use to polymerize acrylamide (AAm) in benzene to form polybutadiene/polyacrylamide (PBD/PAAm) block copolymers. High conversion of AAm was obtained over a wide range of monomer/macroinitiator ratios. The PBD/PAAm block copolymers were found to have excellent solvent resistance.

关键词： AZO-CONTAINING POLYBUTADIENE MACROINITIATOR PBD/PAAM BLOCK COpolymer amphiphilic polymer

Synthesis of a reduction-sensitive Bletilla striata polysaccharide amphiphilic copolymer

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Chinese Chemical Letters 2018年第6期29卷 831-833页

作者： Dandan Sun Miao Wang Danyang Ji Jin Qiao Tong He Xin Liu Qingxiang Guan School of Pharmacy Jilin University

Recently, much special attention has been focused on the development of amphiphilic ***, a reduction-sensitive stearic acid grafted-Bletilla striata polysaccharide copolymer（BSP-ss-SA）was synthesized and characterized. BSP-ss-SA copolymer could spontaneously form micelles with an average particle size of（106 ？ 4.36） nm. Particle sizes were dramatically larger under 10 mmol/L dithiothreitol（DTT） than that in absence of 10 mmol/L DTT. Docetaxel loading content and encapsulation efficiency of micelles were 5.94 wt% and 72.75 wt%, respectively. The docetaxel release rate in vitro in micelles could be remarkably accelerated in pH 7.4 phosphate buffer solution（PBS） containing 10 mmol/L DTT compared with that of micelles（0 mmol/L DTT）. Furthermore, MTT results demonstrated the anticancer activities in vitro of docetaxel-loaded BSP-ss-SA micelles on HepG2 were superior to that of docetaxel injection. BSP-ss-SA copolymer might be a promising nanocarrier for cancer chemotherapy drugs.

关键词： Bletilla striata amphiphilic polymer Micelle Reduction sensitivity Anticancer activity

amphiphilic Polyphosphazene with Poly(ethylene oxide) Side Chains Prepared through the Decker-Forster Reaction

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Journal of Wuhan University of Technology(Materials Science) 2006年第2期21卷 56-60页

作者：刘承美 Department of Chemistry Huazhong University of Science and TechnologyWuhan 430074China

Poly （4- methylphenoxyphosphnzene ） -graft-poly （ ethylene oxide ）（ PPZ-g- PEO ）, a novel amphiphilie grafting polymer was prepared via the Decker-Forster reaction. It is found that the graft efficiency increased with extension of reaction time. Low molecular weight of poly （ ethylene oxide ） favored the grafting reaction. The grafted polymer has two different glass transition temperatures（ Tg） with those of pure poly（ 4-methyl- phenoxy-phopsphazene ） and PEO. The emulsifying ability of grafted polymer was studied with benzene-water mixtare. The emulsifying volumes increased with the decreasing of PEO＇ s molecular weight. The contact angle of film forming from grafted polymer decreased after introduction of PEO grafting chain.

关键词： amphiphilic polymer polyphosphazene poly ( ethylene oxide ) grafting polymer Decker-Forster reaction

Dissipative Particle Dynamics Study on Aggregation of MPEG- PAE-PLA Block polymer Micelles Loading Doxorubicine

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Chinese Journal of Chemistry 2012年第9期30卷 1980-1986页

作者：杨楚芬孙尧章莉娟朱国典张灿阳钱宇 School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhouGuangdong 510640China Faculty of Chemical Engineering&Light Industry Guangdong University of TechnologyGuangzhouGuangdong 510006China

To guide the molecular design of the pH-sensitive triblock amphiphilic polymer MPEG-PAE-PLA and the for- mula design of its doxorubicine （DOX）-loaded micelles, dissipative particle dynamics （DPD） simulations are em- ployed to investigate the aggregation behaviors of the DOX-loaded micelles. The simulation results showed that the aggregate morphologies of micelles and DOX distribution are influenced by degree of polymerization of blocks, and the proposed structure of polymer is MPEG44-PAE3-PLA4. With different contents of polymer or DOX, differ- ent aggregate morphologies of the micelles, like microsphere, spindle/column, reticulation or lamella are observed. To prepare the micro-spherical DOX-loaded micelles, the polymer content is proposed as 10%--15%, and the DOX content less than 10%.

关键词： dissipative particle dynamics pH-sensitive polymer amphiphilic polymer drug-loaded micelles

SYNTHESIS OF POLYACRYLAMIDE WITH PENDANT POLY(BUTYL ACRYLATE) CHAINS USING THE MACROMER TECHNIQUE AND STUDIES ON THEIR PROPERTIES

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Chinese Journal of polymer Science 2004年第1期22卷 91-98页

作者：谢洪泉 Department of Chemistry Huazhong University of Science and Technology Wuhan 430074 China

An amphiphilic graft polymer, (PAM-g-PBA), polyacrylamide (PAM) having poly(n-butyl acrylate) (PBA) side chains, was obtained by radical copolymerization of acrylamide with PBA macromer in solution. The macromer was synthesized by free radical polymerization of butyl acrylate in the presence of different amounts of thioglycolic acid as the chain transfer agent, followed by termination with glycidyl methacrylate. The reactivity ratio and effects of copolymerization conditions on the conversion of macromer or grafting efficiency were studied. The crude products were purified by extraction with toluene and water successively. The purified graft copolymer was characterized by IR, DSC and TEM. PAM-g-PBA can bring about microphase separation and exhibits good emulsifying properties and water absorbency. PAM-g-PBA exhibits a very good compatibilizing effect on the acrylic rubber/poly(vinyl chloride) blends. 2%-3% of the graft copolymer is enough for enhancing the tensile strength of the blends. The tensile strength of the blends is more than twice that without the compatibilizer. DSC and SEM demonstrated the enhancement of compatibility in the presence of the graft copolymer.

关键词： Graft copolymerization Macromer amphiphilic polymer Blend Compatibilizer