Synthesis of a reduction-sensitive Bletilla striata polysaccharide amphiphilic copolymer

作     者：Dandan Sun Miao Wang Danyang Ji Jin Qiao Tong He Xin Liu Qingxiang Guan 

作者机构：School of Pharmacy Jilin University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2018年第29卷第6期

页      面：831-833页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学] 

基　　金：supported by Health and Family Planning Commission of Jilin Province (No. 2017J056) 

主　　题：Bletilla striata Amphiphilic polymer Micelle Reduction sensitivity Anticancer activity 

摘      要：Recently, much special attention has been focused on the development of amphiphilic ***, a reduction-sensitive stearic acid grafted-Bletilla striata polysaccharide copolymer（BSP-ss-SA）was synthesized and characterized. BSP-ss-SA copolymer could spontaneously form micelles with an average particle size of（106 ？ 4.36） nm. Particle sizes were dramatically larger under 10 mmol/L dithiothreitol（DTT） than that in absence of 10 mmol/L DTT. Docetaxel loading content and encapsulation efficiency of micelles were 5.94 wt% and 72.75 wt%, respectively. The docetaxel release rate in vitro in micelles could be remarkably accelerated in pH 7.4 phosphate buffer solution（PBS） containing 10 mmol/L DTT compared with that of micelles（0 mmol/L DTT）. Furthermore, MTT results demonstrated the anticancer activities in vitro of docetaxel-loaded BSP-ss-SA micelles on HepG2 were superior to that of docetaxel injection. BSP-ss-SA copolymer might be a promising nanocarrier for cancer chemotherapy drugs.