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Phytochemical screening of the exudate of aloe otallensis and its effect on Leishmania donovani

Journal of Coastal Life Medicine 2016年第6期4卷 479-482页

作者： Zerihun Tesfaye Nigusse Woldea Abebe Wondifraw Sefinew Migbaru Abate Department of Pharmacy Tikur Anbessa Specialized HospitalCollege of Health SciencesAddis Ababa UniversityP.O.Box 1176Addis AbabaEthiopia Outpatient Pharmacy Case Team Debre Markos Referral HospitalEast Gojjame ZoneAmhara Regional StateP.O.Box 37Debre MarkosEthiopia Oncology Pharmacy Case Team Tikur Anbessa Specialized HospitalCollege of Health SciencesAddis Ababa UniversityP.O.Box 1176Addis AbabaEthiopia

Objective:To evaluate the antileishmanial activity of methanolic extract of aloe otallensis(***)on the promastigote stage of Leishmania donovani(***)as compared to standard drugs and to screen its phytochemical ***:Phytochemical screening was done by using the method mentioned by Evans and Trease on methanolic extract of the exudates of aloe otallensis *** extract was also evaluated for in vitro antileishmanial activity against *** which is found from the Parasitology Unit of Black Lion *** result was compared to standard drugs of sodium stibogluconate,milfostin and ***:The extract has a good antileishmanial activity with an IC_(50)of 0.1230μg/mL on ***(AM 563).The experimental data showed that relatively it had better activity than paramomycin and milfostin but less activity than sodium *** data analyses were done by GraphPad Prism version 5 software after it was read by ELISA reader at the wave length of 650 *** phytochemical screening of the exudates of *** showed the presence of phenol,alkaloid and ***:The methanol extract of the exudates of *** has a good anti-leishmaniasis activity and this may be attributed to phenol,alkaloid and saponin present in the *** it needs further analysis for the conformation of which constituent presents in high concentration to know which one has the strongest effect.

关键词： Anti-leishmaniasis aloe otallensis Leishmania donovani IC_(50)

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