Phytochemical screening of the exudate of Aloe otallensis and its effect on Leishmania donovani
Phytochemical screening of the exudate of Aloe otallensis and its effect on Leishmania donovani作者机构：Department of PharmacyTikur Anbessa Specialized HospitalCollege of Health SciencesAddis Ababa UniversityP.O.Box 1176Addis AbabaEthiopia Outpatient Pharmacy Case TeamDebre Markos Referral HospitalEast Gojjame ZoneAmhara Regional StateP.O.Box 37Debre MarkosEthiopia Oncology Pharmacy Case TeamTikur Anbessa Specialized HospitalCollege of Health SciencesAddis Ababa UniversityP.O.Box 1176Addis AbabaEthiopia
出 版 物：《Journal of Coastal Life Medicine》 (海岸生命医学杂志（英文版）)
年 卷 期：2016年第4卷第6期
页 面：479-482页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：Anti-leishmaniasis Aloe otallensis Leishmania donovani IC_(50)
摘 要：Objective:To evaluate the antileishmanial activity of methanolic extract of Aloe otallensis(***)on the promastigote stage of Leishmania donovani(***)as compared to standard drugs and to screen its phytochemical ***:Phytochemical screening was done by using the method mentioned by Evans and Trease on methanolic extract of the exudates of Aloe otallensis *** extract was also evaluated for in vitro antileishmanial activity against *** which is found from the Parasitology Unit of Black Lion *** result was compared to standard drugs of sodium stibogluconate,milfostin and ***:The extract has a good antileishmanial activity with an IC_(50)of 0.1230μg/mL on ***(AM 563).The experimental data showed that relatively it had better activity than paramomycin and milfostin but less activity than sodium *** data analyses were done by GraphPad Prism version 5 software after it was read by ELISA reader at the wave length of 650 *** phytochemical screening of the exudates of *** showed the presence of phenol,alkaloid and ***:The methanol extract of the exudates of *** has a good anti-leishmaniasis activity and this may be attributed to phenol,alkaloid and saponin present in the *** it needs further analysis for the conformation of which constituent presents in high concentration to know which one has the strongest effect.
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