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Genetic variation in alkaloid accumulation in leaves of Nicotiana

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第12期14卷 1100-1109页

作者： Bo SUN Fen ZHANG Guo-jun ZHOU Guo-hai CHU Fang-fang HUANG Qiao-mei WANG Li-feng JIN Fu-cheng LIN Jun YANG Zhengzhou Tobacco Research Institute Technology Center China Tobacco Zhejiang Industrial Co. Ltd. College of Agriculture & Biotechnology Zhejiang University

alkaloids are plant secondary metabolites that are widely distributed in Nicotiana species and contribute greatly to the quality of tobacco leaves. Some alkaloids, such as nornicotine and myosmine, have adverse effects on human health. To reduce the content of harmful alkaloids in tobacco leaves through conventional breeding, a genetic study of the alkaloid variation among different genotypes is required. In this study, alkaloid profiles in leaves of five Nicotiana tabacum cultivars and Nicotiana tomentosiformis were investigated. Six alkaloids were identified from all six genotypes via gas chromatograph-mass spectrometry(GC-MS). Significant differences in alkaloid content were observed both among different leaf positions and among cultivars. The contents of nornicotine and myosmine were positively and significantly correlated(R2=0.881), and were also separated from those of other alkaloids by clustering. Thus, the genotype plays a major role in alkaloid accumulation, indicating a high potential for manipulation of alkaloid content through traditional breeding.

关键词： alkaloid Genetic effects Nicotiana

A New Dendrobine-Type alkaloid from Dendrobium nobile

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Chinese Chemical Letters 2003年第3期14卷 278-279页

作者： Qun Fang LIU Wei Min ZHAO ShanghaiInstituteofMateriamedica ShanghaiInstituteforBiologicalSciencesChineseAcademyofSciencesShanghai200031 ShanghaiInstituteofMateriamedica ShanghaiInstituteforBiologicalScie

A new dendrobine-type alkaloid has been isolated from stems of Dendrobium nobile lindl.. Its structure has been identified on the basis of spectroscopic method.

关键词： Dendrobium nobile Orchidaceae alkaloid dendronobiline A.

Three pairs of alkaloid enantiomers from the root of Isatis indigotica

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Acta Pharmaceutica Sinica B 2016年第2期6卷 141-147,188页

作者： Yufeng Liu Xiaoliang Wang Minghua Chen Sheng Lin Li Li Jiangong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College Department of Pharmacy Jining Medical University Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College

Three pairs of enantiomerically pure alkaloids with diverse structure features, named isatindigoticoic acid A and epiisatindigoticoic acid A [(—)-1 and(+)-1], phaitanthrin A and epiphaitanthrin A [(—)-2 and(+)-2], and isatindopyrromizol A and epiisatindopyrromizol A [(—)-3and(+)-3], respectively, were isolated from an aqueous extract of the roots of Isatis indigotica. Racemic and scalemic mixtures of these enantiomers were separated by HPLC on a chiral semi-preparative *** structures including absolute configurations were determined by extensive spectroscopic analysis in conjunction with the calculation of electronic circular dichroism(ECD) spectra. The enantiomer pairs possess parent structures of 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid, indolo[2,1-b]quinazolinone, and 3-thioxohexahydro-1H-pyrrolo[1,2-c]imidazol-1-one, respectively. Except for phaitanthrin A[(—)-2] which the configuration was previously undetermined, these compounds are new enantiomeric natural products.

关键词： Cruciferae Isatis indigotica alkaloid enantiomer Chiral separation 2-Oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid Indolo[2,1-b]quinazolinone 3-Thioxohexahydro-1H-pyrrolo[1,2-c]imidazol-1-one

A new steroidal alkaloid from Beaumontia grandiflora

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Chinese Chemical Letters 2009年第9期20卷 1094-1096页

作者： Li Ma Jian Guang Luo Yu Cheng Gu Ling Yi Kong Department of Natural Medicinal Chemistry China Pharmaceutical University 24 Tong Jia Xiang Nanjing 210009 People's Republic of China Syngenta Jealott's Hill International Research Centre Bracknell Berkshire RG42 6EY United Kingdom

A new steroidal alkaloid, beaumontamine （1）, was isolated from the stems of Beaumontia grandiflora. The structure was elucidated on the basis of spectral analysis. 2009 L.Y. Kong. Published by Elsevier B.V. on beh... 详细信息

关键词： Beaumontia grandiflora Beaurnontamine alkaloid

Non-Flat Bisbenzylisoquinoline alkaloid Fangchinoline As a Class of Potent G-Quadruplex Stabilizer with Anti-cancer Activity

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Chinese Journal of Chemistry 2015年第9期33卷 1041-1048页

作者： Qian Li Junfeng Xiang Yalin Tang Beijing National Laboratory for Molecular Sciences (BNLMS) Center for Molecular SciencesState Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Aeademy of Sciences Beijing 100190 China

Compounds selectively binding and stabilizing G-quadruplex structures could inhibit the telomerase or down- regulate the oncogenes and may act as anti-cancer drugs. An alkaloid with non-flat structure, fangchinoline, showed to strongly stabilize the intermolecular and intramolecular parallel stranded G-quadruplex structure, increasing melting temperature by 20 and 23℃, respectively. The binding mode was investigated by using NMR and molec- ular modelling methods. Four human cell lines （HL-60, BGC-823, Be1-7402 and KB） were taken to test the an- ti-proliferation effects of fangchinoline and the IC50 values were ranged from 16 to 32 μmol/L. These results showed that the fangchinoline or related moiety derivatives may represent a class of telomere-targeted agents as po- tential anti-cancer drugs.

关键词： G-quadruplex alkaloid non-flat anti-cancer drug

A new alkaloid from Solanum cathayanum

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Chinese Chemical Letters 2008年第1期19卷 68-70页

作者： Fan Cheng Xiang Li Jun Zhi Wang Hubei Key Laboratory of Natural Products Research and Development College of Chemistry and Life Science China Three Gorges University Yichang 443002 China Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China

A new alkaloid compound I was obtained from Solanum cathayanum, a folk medicine of Hubei Province, together with a known alkaloid, orotic acid ethyl ester. On the basis of spectroscopic data and chemical methods, I was identified as 8-hydroxy-3-methoxy- 5H-pyrido[2, 1-c]pyrazin-5-one. Compound I can inhibit the production of NO in peritoneal macrophage of mice induced with LPS. The content of NO was determined by enzyme methods. 2007 Jun Zhi Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： alkaloid Solarium cathayanum Folk medicine Nitrogen monoxide

A novel alkaloid from the fruiting bodies of Ganoderma sinense Zhao,Xu et Zhang

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Chinese Chemical Letters 2010年第2期21卷 197-199页

作者： Liu, Chao Zhao, Fen Chen, RuoYun Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Minist Educ Key Lab Bioact Substances & Resources Utilizat Ch Beijing 100050 Peoples R China

A new alkaloid,sinensine(1),had been isolated from the fruiting bodies of Ganoderma sinense Zhao,Xu et *** structure was elucidated on the basis of 1D and 2D spectral *** alkaloid exhibited activity in protecting the ... 详细信息

关键词： alkaloid Ganoderma sinense Sinensine

A new veratramine alkaloid from the bulbs of Fritillaria hupehensis

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Chinese Chemical Letters 2007年第2期18卷 175-177页

作者： Tetsuro Fujita Faculty of Pharmaceutical Sciences Kyoto UniversityKyoto 606-01Japan

A new highly conjugated alkaloid of veratramine type, 22S,25S,5α-veratramine-7(8),12(14)-diene-3β,13β,23β-triol-6-one (1), was isolated from the bulbs of Fritillaria hupehensis Hsiao et K.C. Hsia. Its structure wa... 详细信息

关键词： Fritillaria hupehensis alkaloid Veratramine group

A New alkaloid from Sinomenium acutum

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Chinese Chemical Letters 2005年第11期16卷 1481-1483页

作者： Wei Ming CHENG Feng QIU Li Jun WU Xin Sheng YAO Department of Natural Products Chemistry Shenyang Pharmaceutical University Shenyang 110016

Sinomenium acutum is widely used in East and South Asia for the treatment of many diseases, especially rheumatoid arthritis （RA）. The chemical research on Sinomenium acutum led to the isolation of a new alkaloid compound （1）. On the basis of chemical evidences and spectral analysis, 1 was identified as N-（1, 7-dimethoxylphenanthren-2-yl）acetamide.

关键词： Sinomenium acutum alkaloid N-(l 7-dimethoxylphenanthren-2-yl)acetamide.