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Effect of albendazole and Mebendazole on Hydatid Cyst of Mice

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Open Journal of Epidemiology 2017年第4期7卷 307-316页

作者： Ekram Ismail Fagiree Ismail Mohammed Bahaa Eldeen Ahmed Saad Aisha Abass Elsadig Department of Biology Alzaem Alazhari University Khartoum Sudan Alahlia University Khartoum Sudan Department of Radioisotopes of the Veterinary Research Center Khartoum Sudan

In the current study, hydatid cysts from livers and lungs of camels were obtained from Tambool slaughter house and protoscoleces were separated aseptically. 36-weeks-old Swiss mice (25 - 30 gram body weight males and females) were divided into two groups of 6 each: a prophylactic group dosed with 150 ml/kg of albendazole and mebendazole was given directly after injection with 2000 protoscoleces intraperitoneally for 10 consecutive days. The treated group was given a dose of 300 ml/kg of albendazole and mebendazole for 24 days with 4 days interval separated by 2 days and after 6 months of inoculation with protoscoleces, the two groups in addition to the control group were sacrificed and necropsied. The results revealed a significant difference in the development of hydatid cyst (p albendazole and mebendazole compared to the control group, however, albendazole was highly efficacious than the mebendazole where the efficiency of albendazole reached 97% while the mebendazole efficiency rate was almost 50% which indicates that albendazole could be considered the drug of choice in the treatment of hydatid cyst.

关键词： Hydatid Cyst Mebendazole albendazole

Protective Effects of Vitamin E on albendazole Adverse Effects

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Open Journal of Veterinary Medicine 2021年第10期11卷 307-314页

作者： Catherin V. Adiang Sawsan M. El-Sheik Gamal El-Din A. Shams Abdel Aleem Fouad AbdelAleem Department of Pharmacology Faculty of Veterinary Zagazig University Zagazig Egypt

The present study was conducted to determine the effect of albendazole alone or in combination with vitamin E on antioxidant activity and histopathological, changes on the liver and kidney. Following oral administration of albendazole of 0.25 mg/kg body weight and Vitamin E of 0.01 mg/kg body weight used for 21 successive days to broiler chicken, the experiment was done on fifteen broiler chickens divided into three groups: group one was non-treated, group two was treated with albendazole of 0.25 mg/kg body weight and group three was treated in combination with vitamin E of 0.01 mg/kg body weight. The blood sample and tissue were taken at the end

关键词： albendazole Vitamin E Antioxidant Enzymes

Inhibition of albendazole and Oxfendazole on the Activity of Fumaric Reductase in Cysticercus cellulosae

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Journal of Northeast Agricultural University(English Edition) 2004年第2期11卷 156-159页

作者： GAOXue-jun LIQing-zhang LIXia AnimalMedicineCollege NortheastAgriculturalUniversityHarbinHeilongjiang150030PRC

The activity of fumaric reductase in Cysticercus cellulosae tissue homogenate with albendazole and oxfendazole individually was detected. Results showed that the two kinds of drugs both could inhabite the activity of fumaric reductase. The results indicate that the mechanism of action of benzimidazole carbamate drugs is probably inhabiting the complex of fumaric reductase noncompetently, thus lead to the exhaostion of energy and death.

关键词： albendazole oxfendazole Cysticercus cellulosae fumaric reductase

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Determination of albendazole and its metabolites in animal tissues by HPLC-FLD

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Determination of albendazole and its metabolites in animal t...

albendazole对绵羊肝蛭的驱虫效果

河南省化学会2016年学术年会

作者： Yanlong Chen Huifang Du Gaigai Xu Shengnan Zhao Ningpeng Wu Zhifen Deng Wenfen Zhang Shusheng Zhang Veterinary Drug Supervision & Animal Husbandry Bureau of Henan Province College of Chemistry and Molecular Engineering Zhengzhou University

Food safety has as a Global Concern problem, and illicit drugs in food detection and drug residual problem gradually become a hot issue. albendazole is anthelmintic benzimidazole most widely used as veterinary medicine for the treatment of infections caused *** of albendazole has potential harm to human body, so many countries have regulations maximum residue and the method has established for detecting albendazole and its metabolites in animal tissues. However, most of detection methods had serious impurity interference, so it is necessary to establish a new method for sample preparation. In this paper, a high-performance liquid chromatography with fluorescence detection(HPLC-FLD) method, using acidic alumina and MCX solid-phase extraction(SPE) cartridges was developed for extracting and purifying the albendazole and its metabolites in animal *** limits of detection(LOD) were about 1-10 ng/m L, the limits of quantification(LOQ) were 4.0 and 20.0ng/m L for albendazole and its metabolites. The intraday and interday RSDs(n=6) of peak areas and retention times were in the range of 2.0.-15%. In addition, overall recoveries through the extraction and SPE purification ranged from 78.4% to 102.8%. Compared with others detection methods, the two cartridges(acidic alumina and MCX) in series connection was proposed SPE-HPLC–FLD method had highly effective and good purification effects for trace analysis of the albendazole and its metabolites.

关键词： albendazole solid-phase extraction(SPE)

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浙江畜牧兽医 1980年第3期 52-53+48页

作者：何秉耀浙江农科院畜牧所

以新药albendazole(甲基[5-(丙烷基硫)-1H-苯吲哚-2yl]氨基碳酸盐)(mes-thyl[5-(Propylthio)-1Hbenzinidazol-2yl」Carbanaty),给90头人工感染肝蛭的绵羊作驱虫试验,按体重10,15和20mg/kg的剂量给药,对肝蛭成虫的驱虫率为98,95和100%;而对感染后3周的童虫的效果较差,用20,30,40和50mg/kg的剂量只有24,47,63和76%的驱虫效果。用药量为20mg/kg的羊,投药后48小时介剖在肝管中就没有发现肝蛭,未见药物对羊有毒性。

关键词：驱虫效果 albendazole 羊肝包囊绵羊

丙硫咪唑(albendazole)治疗儿童肠蠕虫驱虫效果观察

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新疆医学院学报 1983年第1期 15-17页

作者：寄生虫学教研室新疆医学院寄生虫学教研室新疆医学院第一附属医院儿科新疆医学院第一附属医院检验科

本文报告了对65名感染肠蠕虫的儿童进行丙硫咪唑驱虫效果观察。结果表明,顿服此药400mg,对蛲虫和蛔虫感染有良好的效果;对短膜壳绦虫感染效果不显著;对鞭虫感染无效。对蛔虫卵无致死或抑制其发育的作用。

关键词：驱虫效果丙硫咪唑 albendazole 虫卵短膜壳绦虫儿童蠕虫体内寄生虫

国产丙硫咪唑(albendazole)对凉山黑猪寄生蠕虫的驱虫试验

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西南民族学院学报(畜牧兽医版) 1986年第3期 21-23页

作者：何绍江万太全田先贵哈马拉史

凉山黑猪系云、贵、川三省接壤地区马金猪的一个类群,具有御寒力强,耐粗饲,易放牧等优点,是凉山彝族自治州高寒山区的当家猪种。在1984年11月—1985年6月的凉山州畜禽寄生虫调查中,发现此猪的寄生蠕虫多达23种,最多混合感染13种,最大... 详细信息

凉山黑猪系云、贵、川三省接壤地区马金猪的一个类群,具有御寒力强,耐粗饲,易放牧等优点,是凉山彝族自治州高寒山区的当家猪种。在1984年11月—1985年6月的凉山州畜禽寄生虫调查中,发现此猪的寄生蠕虫多达23种,最多混合感染13种,最大荷虫量2262条。尤以细颈囊尾蚴、长刺后园线虫、胃线虫、猪蛔虫、猪毛首线虫、有齿食

关键词：丙硫咪唑 albendazole 寄生蠕虫猪毛首线虫猪蛔虫细颈囊尾蚴有齿食道口线虫驱虫率混合感染高寒山区

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丙硫苯咪唑 (albendazole)

重庆医学 1987年第1期 63-64页

作者：贾杰

1986年11月16日,重庆医科大学举办了丙硫苯眯唑(肠虫清)国际学术讲座会,世界卫生组织寄生虫规划委员会主任Davis博士和Rossignol博士,以及我国专家刘约翰教授、丁兆勋教授及王其南教

关键词：疗程血浆副作用 albendazole 大白鼠家鼠属包虫病剂量用药量

国产丙硫苯咪唑(albendazole)驱鸡蠕虫试验报告

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贵州畜牧兽医科技 1984年第3期 5-9页

作者：陈荣辉刘琴英王远忠胡志能王修文陈伟俊陈宝全胡德林刘克强李兴卫贵阳市畜牧局贵州省畜牧兽医科学研究所贵阳市南明区农水局

我市养鸡专业户发展迅速,养鸡数量逐年增加,不少养鸡户为城市提供了较多的禽、蛋商品,取得了较好的经济效益。但有的养鸡户缺乏实践知识与先进技术,因此未能取得应有的经济效果,其中鸡的体内寄生虫病就是一个严重的问题。鸡的蠕虫病是... 详细信息

我市养鸡专业户发展迅速,养鸡数量逐年增加,不少养鸡户为城市提供了较多的禽、蛋商品,取得了较好的经济效益。但有的养鸡户缺乏实践知识与先进技术,因此未能取得应有的经济效果,其中鸡的体内寄生虫病就是一个严重的问题。鸡的蠕虫病是一种常见的多发的慢性消耗性疾病,它降低饲料报酬,增加饲养成小;降低产肉、产蛋率,不仅影响生长发育,甚至造成大批幼鸡死亡。为使专业户养鸡取得最佳经济效益;应用国产驱虫新药丙硫苯咪唑对本地区专业户的鸡只作了驱虫剂量试验和大群驱虫试验,为专业户养鸡驱虫提供科学依据。现将试验结果报告如下:

关键词：鸡蛔虫病蛔虫养鸡专业户鸡绦虫驱虫率鸡异刺线虫 albendazole 四角赖利绦虫驱虫效果蠕虫体内寄生虫