Inhibition of Albendazole and Oxfendazole on the Activity of Fumaric Reductase in Cysticercus cellulosae

作     者：GAOXue-jun LIQing-zhang LIXia 

作者机构：AnimalMedicineCollegeNortheastAgriculturalUniversityHarbinHeilongjiang150030PRC 

出 版 物：《Journal of Northeast Agricultural University(English Edition)》 (东北农业大学学报（英文版）)

年 卷 期：2004年第11卷第2期

页      面：156-159页

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：SupportedbytheNationalNaturalScienceFoundation(30371081) 

主　　题：albendazole oxfendazole Cysticercus cellulosae fumaric reductase 

摘      要：The activity of fumaric reductase in Cysticercus cellulosae tissue homogenate with albendazole and oxfendazole individually was detected. Results showed that the two kinds of drugs both could inhabite the activity of fumaric reductase. The results indicate that the mechanism of action of benzimidazole carbamate drugs is probably inhabiting the complex of fumaric reductase noncompetently, thus lead to the exhaostion of energy and death.