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Triterpenoid Saponins from Leaves of akebia trifoliata and Their Bioactivities

Triterpenoid Saponins from Leaves of Akebia trifoliata and T...

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中国化学会第十二届全国天然有机化学学术会议

作者： Li-Mei Dong Jin-Kui Ouyang Qiao-Lin Xu Jian-Wen Tan Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of Forestry State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Forestry and Landscape ArchitectureSouth China Agricultural University

akebia trifoliata(Thunb.) Koidz is a perennial,woody liana mainly distributed in the eastern part of *** plant has traditionally been used in China for centuries as an antiphlogistic,antineoplastic and diuretic *** date,phytochemical studies have revealed structurally diverse triterpenes,triterpene saponins,phenolics and lignans from this ***,those studies were mainly concentrated on the stems and fruits,and seldomly focused on the ***,we carried out a phytochemical investigation on the leaves of *** and some oleanane triterpene saponins were *** continuation of this research,six new pentacyclic triterpene saponins were further *** the bases of extensive spectroscopic analysis,these new triterpene saponins were identified as 3-O-β-D-glucopyranosyl-2α,3β,20β,23-tetrahydroxy taraxastan-28,20β-olide(1),3-O-β-D-glucopyranosyl-3β,21β-dihydroxy-taraxastan-28,29-diate(2),2α,3β-dihydroxy-23-oxo-olean-12,20(29)-dien-28-oicacid-O-β-D-glucopyranosyl-(1→6)-β-Dglucopyranosyl ester(3),2α,3β,23-trihydroxy-29-norolean-12,20(29)-dien-28-oic acid-O-β-Dglucopyranosyl-(1→6)-β-D-glucopyranosyl ester(4),2α,3β,23-trihydroxylup-20(29)-en-28-oic acid-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester(5) and 2α,3β,23,29-tetra hy droxy ol ean-12-en-2 8-oi c acid-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester(6).Compounds 3-5 showed more potent in vitro α-glucosidase inhibitory activity than reference compound *** 1 and 2 displayed significant in vitro growth inhibitory activity against human tumor MCF-7 and HepG2 cell lines(IC≤10 μM).

关键词： akebia trifoliata Triterpenoid saponins Bioactivity

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Bioactive Triterpene Acids from Pericarps of akebia trifoliata(Thunb.)Koidz

Bioactive Triterpene Acids from Pericarps of Akebia trifolia...

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中国化学会第十二届全国天然有机化学学术会议

作者： Jin-Kui Ouyang Li-Mei Dong Qiao-Lin Xu Jian-Wen Tan State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Forestry and Landscape ArchitectureSouth China Agricultural University Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of Forestry

akebia trifoliata(Thunb.) Koidz has long been used as a diuretic and an antiphlogistic in traditional Chinese medicine for *** far,phytochemical studies on the stems of this plant have revealed structurally diverse triterpenoids,phenolics and *** pericarp of *** was deduced to be rich in bioactive chemicals which might be ideal candidates that could be developed as effective and safe agents for pharmaceutical ***,those potential bioactive compounds in the pericarps have yet not well been ***,we carried out a phytochemical study on the pericarps of ***,by which a series of oleanane-type triterpenoids were identified and some of them showed antimicrobial *** continuation of this work,six new triterpene acids(1-6) were further *** on extensive spectroscopic analysis,these new structures were elucidated as 2α,3β,23-trihydroxymultiflor-7-en-28-oic acid(1),2α,3β,23-trihydroxy-taraxastan-28,20β-olide(2),2,29-dihydroxy-3-oxo-23-noroleana-1,4,12-trien-28-acid(3),3-hydroxy-2-oxo-23-noroleana-3,12-dien-28-acid(4),2-hydroxy-3-oxo-23,29-dinor oleana-1,4,12-trien-28-acid(5) and 4-oxo-3,23-dinor-2,3-seco-olean-12-ene-2,28-diate(6).In vitro antibacterial assay revealed that compounds 3-5 were active against tested gram-(+) bacteria Staphyloccocus Aureus(CMCC26003),Bacillus Cereus(CMCC63302) and Bacillus Subtilis(CMCC63501) with MIC values ranging from 6.25 to 12.5 μg/***,compounds 3-5 were further revealed to show in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines.

关键词： akebia trifoliata Triterpene acids Bioactivity

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