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agranulocytosis following injection of inactivated Japanese encephalitis vaccine(Vero cell):A case report

World Journal of Clinical Cases 2021年第25期9卷 7468-7471页

作者： Li Wang Xu Zhang Yan-Tao Liu Department of Pharmacy West China Second University HospitalSichuan University/Evidence-Based Pharmacy CenterWest China Second University HospitalSichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and ChildrenSichuan UniversityMinistry of EducationChengdu 610041Sichuan ProvinceChina Department of Pharmacy West China Second University HospitalSichuan University/Evidence-Based Pharmacy CenterWest China Second University HospitalSichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and ChildrenSichuan UniversityMinistry of EducationChengdu 610041Sichuan ProvinceChina/Department of PharmacyDechang People's HospitalLiangshan 615500Sichuan ProvinceChina

BACKGROUND Japanese encephalitis virus(JEV),a mosquito borne flavivirus,is the leading cause of viral encephalitis in Asia,in terms of frequency and *** infection is thought to confer lifelong *** the near eradication of poliomyelitis,JEV is now the continent’s leading cause of childhood viral neurologic infection and *** most common clinical manifestation of JEV infection is acute encephalitis,and currently there is no specific antiviral *** Encephalitis Vaccine(JE-VC)is an effective prevention measure,including JE-VC,Live(JE-MB),and Inactivated *** SUMMARY A 9-mo-old girl received injection of Inactivated JE-VC(Vero cell)(Liaoning Chengda,batch number 201611B17)on August 31,*** that night,she developed a fever with the body temperature up to 38.5°C,for which Ibuprofen Suspension Drops 1.25 mL was given as antipyretic *** September 1,the patient developed apocleisis,and her parents noticed herpes in her oral *** patient was sent to our hospital on September *** examination led to a diagnosis of herpetic stomatitis,for which Stomatitis Spray 1 puff,tid,Kangfuxin Liquid 2 mL,tid,and vitamin B20.5 tablet,tid,were *** blood tests for low fever on September 6,2017 revealed an absolute neutrophil count(ANC)of 0.62×109/L,hemoglobin(Hb)of 109 g/L,and platelet count(PLT)of 308×10^(12)/L,and the tests were monitored regularly *** patient was followed until July 26,2020,when routine blood tests revealed ANC 1.72×109/L,Hb 138 g/L,and PLT 309×1012/L,indicating that the neutropenia count had *** This report attempts to bring to clinical attention that Inactivated JE-VC(Vero cell)might cause prolonged granulocytopenia or even agranulocytosis.

关键词： Inactivated Japanese Encephalitis Vaccine(Vero cell) Neutropenia agranulocytosis Japanese Encephalitis virus Case report

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Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9921-9928页

作者： You-Lin Shao Chun-Ming Ma Jian-Ming Wu Feng-Cai Guo Suo-Cai Zhang Department of Hepatology Changzhou Third People's HospitalChangzhou 213001Jiangsu ProvinceChina

BACKGROUND Various types of drug-induced liver injury are induced by Polygonum multiflorum(PM);however,it rarely causes ***,we report the case of a 65-year-old woman with concurrent severe hepatotoxicity and agranulocytosis induced by *** SUMMARY A 65-year-old woman reported with severe hepatotoxicity and agranulocytosis 17 d after ingestion of *** results of the Roussel Uclaf Causality Assessment Method demonstrated a highly probable relationship between hepatotoxicity and PM,with a total score of *** Naranjo algorithm results indicated that agranulocytosis had a probable relationship with PM,with an overall score of *** colony-stimulating factor(for once),a steroid,compound glycyrrhizin,and polyene phosphatidylcholine therapy were *** 15 d of treatment,there was a gradual improvement in liver biochemistry,leukocytes,and neutrophils *** Concurrent hepatotoxicity and agranulocytosis are rare and critical adverse drug reactions of PM,which should be highly valued.

关键词： Polygonum multiflorum Hepatotoxicity agranulocytosis Case report

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Disseminated Fusarium bloodstream infection in a child with acute myeloid leukemia:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6049-6055页

作者： Jun-Jie Ning Xue-Mei Li Sheng-Qiu Li Department of PICU First People's Hospital of Zigong CityZigong 643000Sichuan ProvinceChina

BACKGROUND Disseminated Fusarium is rare in healthy *** with hematological tumors may have secondary fungal infections,including Fusarium infections,which are due to tumor bone marrow infiltration or prolonged bone marrow suppression after *** of the lack of typical clinical manifestations and effective antifungal drugs,early diagnosis and treatment of the disease are difficult,and the prognosis is *** SUMMARY The patient in this case was a 13-year-old female child with rash and fever as the first *** had the characteristics of the four stages of skin that are typical of Fusarium *** was diagnosed with disseminated Fusarium infection through skin biopsy and blood culture and diagnosed with Fusarium solani infection based on the morphological characteristics of the blood *** treatment with liposome amphotericin B combined with voriconazole,the child *** This case highlights that for children with secondary agranulocytosis after receiving chemotherapy for hematological malignancies,once typical abnormal skin damage is found,the possibility of Fusarium infection should be considered,and voriconazole alone or in combination with polyenes may be the most effective anti-Fusarium *** B,the traditional drug of disseminated Fusarium disease,has a high mortality rate,and it is not recommended to use it *** neutrophil counts are essential for the treatment of disseminated Fusarium bloodstream infection.

关键词： Fusarium Liposomal amphotericin B Voriconazole Acute myeloid leukemia agranulocytosis Case report

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Clinical Characteristics of Bloodstream Infections in Pediatric Acute Leukemia： A Single-center Experience with 231 Patients

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Chinese Medical Journal 2017年第17期130卷 2076-2081页

作者： Jia-Feng Yao Nan Li Jin Jiang Hematology Oncology Center Beijing Key Laboratory of Pediatric Hematology OncologyNational Key Discipline of PediatricsMinistry of EducationBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background：Acute leukemia is the most common pediatric hematological *** infections （BSIs） are severe complications in these patients during *** study aimed to explore the clinical presentation and etiology of BSI,as well as the common sites of infection,and to provide a basis for the rational regarding antibiotic ***：We performed a retrospective chart review of all pediatric patients who had acute leukemia accompanied by a BSI in our hospital from December 2011 to September *** patients were selected based on clinical presentation and had to have at least one positive blood culture for *** basic clinical characteristics,blood culture results,and antimicrobial susceptibilities were ***：All 231 patients had a fever;of them,12 patients continued to have a ***-five patients had nonremitting （NR） leukemia,and 206 patients achieved complete remission （CR）.Differences in the duration of fever between the NR and CR groups were significant （9.6 ＆#177; 7.9 vs.5.1 ＆#177; 3.8 days,P =0.016）.One hundred and eighty patients had *** in fever duration between the agranulocytosis and nonagranulocytosis groups were significant （6.2 ＆#177; 5.1 vs.4.1 ＆#177; 2.6 days,P =0.001）.The other sites of infection in these 231 patients were the lung,mouth,digestive tract,and *** culture comprised 2635 *** were 619 samples,which were *** the 619 positive blood culture samples,59.9% had Gram-negative bacteria,39.3% had Gram-positive bacteria,and 0.8% had *** primary pathogens were Pseudomonas aeruginosa,Enterobactercloacae,Escherichia coli,and Klebsiella *** these 231 patients,217 patients were *** effective treatment ratio was 94%.Conclusions：Gram-negative bacteria were the main pathogenic bacteria in patients with acute leukemia in our *** primary illness,agranulocytosis,and drug-resistant pathogenic bacteria were all risk factors for poo

关键词： Acute Leukemia agranulocytosis Bloodstream Infection Etiology Pediatric

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