Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum:A case report

作     者：You-Lin Shao Chun-Ming Ma Jian-Ming Wu Feng-Cai Guo Suo-Cai Zhang 

作者机构：Department of HepatologyChangzhou Third People's HospitalChangzhou 213001Jiangsu ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第27期

页      面：9921-9928页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Applied Basic Research Project of Changzhou No.CJ20190080 

主　　题：Polygonum multiflorum Hepatotoxicity Agranulocytosis Case report 

摘      要：BACKGROUND Various types of drug-induced liver injury are induced by Polygonum multiflorum(PM);however,it rarely causes ***,we report the case of a 65-year-old woman with concurrent severe hepatotoxicity and agranulocytosis induced by *** SUMMARY A 65-year-old woman reported with severe hepatotoxicity and agranulocytosis 17 d after ingestion of *** results of the Roussel Uclaf Causality Assessment Method demonstrated a highly probable relationship between hepatotoxicity and PM,with a total score of *** Naranjo algorithm results indicated that agranulocytosis had a probable relationship with PM,with an overall score of *** colony-stimulating factor(for once),a steroid,compound glycyrrhizin,and polyene phosphatidylcholine therapy were *** 15 d of treatment,there was a gradual improvement in liver biochemistry,leukocytes,and neutrophils *** Concurrent hepatotoxicity and agranulocytosis are rare and critical adverse drug reactions of PM,which should be highly valued.