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Effect of Oils on SBS Modified Asphalt:Rheological Characteristics and Oxidation Aging

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Journal of Renewable Materials 2023年第3期11卷 1339-1351页

作者： Jing Xu Yuquan Yao Kai Zhang Jiangang Yang Jie Gao Jian Zhou Jiangxi Transportation Institute Co. Ltd.Nanchang330200China School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang330013China School of Highway Chang’an UniversityXi’an710064China

This study focuses on the effect of oils on rheology and oxidation Aging of Styrene-Butadiene-Styrene modified asphalt(SBSMA)in the long term,after reducing one low-temperature Performance Grade(PG)of SBSMA by incorporating oils.Two oils,including corn-based bio-oil and re-refined engine oil bottom(REOB),were selected to enhance the low-temperature performance of SBSMA.All samples were subjected to Rolling Thin Film Oven(RTFO)Aging and 20-h as well as 40-h Pressure Aging Vessel(PAV20 and PAV40)Aging,prior to multiple stress creep recovery(MSCR),frequency sweep and Flourier transform infrared spectroscopy(FTIR)scanning.A good high-temperature performance of oil/SBS modified asphalt blends was reflected in MSCR and PG results,meanwhile non-recoverable creep compliance(Jnr)and recovery(R)were found to share a highly correlated relationship during Aging progress.In addition,Glover–Rowe(G–R)parameter and phase angle master curves suggest that the improvement of cracking property mainly came from the softening effect of oils.Adding oils into SBSMA was observed to increase oxidation kinetics,but the blends with oils still exhibited better anti-oxidation Aging than the base binder,mainly due to the SBS addition.Bio-oil exhibited an effect of relieving age hardening susceptibility of SBSMA.

关键词： Oil Aging rheology oxidation kinetics cracking resistance

Ultrasound deep brain stimulation decelerates telomere shortening in Alzheimer’s disease and Aging mice

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Fundamental Research 2023年第3期3卷 469-478页

作者： Yaya Zhang Na Pang Xiaowei Huang Wen Meng Long Meng Bingchang Zhang Zhengye Jiang Jing Zhang Zhou Yi Zhiyu Luo Zhanxiang Wang Lili Niu Department of Neurosurgery Xiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversityXiamen 361003China Paul C.Lauterbur Research Center for Biomedical ImAging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Dongguan University of Technology Dongguan 523808China School of Medicine Xiamen UniversityXiamen 361000China Shanghai Green Valley Pharmaceutical Co. LtdShanghai 200120China

Telomere length is a reliable biomarker for health and longevity prediction in both humans and animals.The common neuromodulation techniques,including deep brain stimulation(DBS)and optogenetics,have excellent spatial resolution and depth penetration but require implementation of electrodes or optical fibers.Therefore,it is important to develop methods for noninvasive modulation of telomere length.Herein,we reported on a new method for decelerating telomere shortening using noninvasive ultrasound deep brain stimulation(UDBS).Firstly,we found that UDBS could activate the telomerase-associated proteins in normal mice.Then,in the Alzheimer’s disease mice,UDBS was observed to decelerate telomere shortening of the cortex and myocardial tissue and to effectively improve spatial learning and memory abilities.Similarly,UDBS was found to significantly slow down telomere shortening of the cortex and peripheral blood,and improve motor and cognitive functions in Aging mice.Finally,transcriptome analysis revealed that UDBS upregulated the neuroactive ligand-receptor interaction pathway.Overall,the present findings established the critical role of UDBS in delaying telomere shortening and indicated that ultrasound modulation of telomere length may constitute an effective therapeutic strategy for Aging and Aging-related diseases.

关键词： Noninvasive ultrasound Brain stimulation Telomere length Aging Alzheimer’s disease(AD)

Awakening of ancient retrovirus:a new sign of Aging in humans?

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Science China(Life Sciences) 2023年第6期66卷 1454-1455页

作者： Yuliang Qu Jichang Wang Department of histology and embryology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China Key Laboratory for Stem Cells and Tissue Engineering(Sun Yat-sen University) Ministry of EducationGuangzhou510080China

Endogenous retroviruses(ERVs)are viral elements that have been incorporated into the host genomes of mammals over time and have evolved to become part of the host genome.Some ERVs have been domesticated and serve a role in host development and health.HML-2,a recently integrated family of human endogenous retrovirus K(HERVK)(Garcia-Montojo et al.,2018),is an example of such ERVs and is transcribed during early human development to encode viral proteins that are proposed to promote antiviral immune response and specialization of primordial germ cells(Grow et al.,2015;Xiang et al.,2022).

关键词： endogenous Aging

维普期刊数据库

Combination of High Yield Strength and Improved Ductility of 21Cr Lean Duplex Stainless Steel by Tailoring Cold Deformation and Low-Temperature Short-Term Aging

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 695-702页

作者： Zhenghong Liu Zhigang Wu Ying Han Xiaolei Song Guoqing Zu Weiwei Zhu Xu Ran Key Laboratory of Advanced Structural Materials Ministry of EducationChangchun University of TechnologyChangchun130012China School of Materials Science and Engineering Changchun University of TechnologyChangchun130012China Jilin Province Key Laboratory of Advanced Materials Processing and Application for Rail Transit Changchun University of TechnologyChangchun130012China

Proper matching of cold-rolled deformation and low-temperature short-term Aging can simultaneously enhance the strength and ductility of the lean duplex stainless steel. To investigate this, the microstructure evolution of cold-rolled and Aging steels was observed by using scanning electron microscopy, transmission electron microscopy and electron backscattered diffraction. Additionally, the phase volume fraction was measured using X-ray diffraction. In this study, it was observed that the elongation of 21Cr lean duplex stainless steel significantly increased to 16.7% after undergoing moderate cold deformation (~ 40% reduction) and subsequent Aging treatment at 550 ℃ for 30 min. Remarkably, the material still maintained a high yield strength of 1045 MPa. Such an excellent mechanical property was attributed to a unique microstructure combination of fine α'-martensite, twins, coarsened austenite resulting from partial martensite reverse transformation, and two-phase fine layered structure. The result of this study may open up new horizons for the alloy development in order to overcome the low ductility of cold-rolled high-strength lean duplex stainless steel.

关键词： Lean duplex stainless steel Cold rolling Aging Microstructure Mechanical properties Use our pre-submission checklist

A single-cell transcriptomic atlas of primate pancreatic islet Aging

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National Science Review 2021年第2期8卷 17-31页

作者： Jingyi Li Yuxuan Zheng Pengze Yan Moshi Song Si Wang Liang Sun Zunpeng Liu Shuai Ma Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Weiqi Zhang Guang-Hui Liu Fuchou Tang Jing Qu Gene Expression Laboratory Salk Institute for Biological Studies Ministry of Education Key Laboratory of Cell Proliferation and Differentiation National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences Beijing Institute for Brain Disorders Advanced Innovation Center for Human Brain ProtectionNational Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical University The MOH Key Laboratory of Geriatrics Beijing HospitalNational Center of Gerontology Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking University State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences Institute for Stem Cell and Regeneration Chinese Academy of Sciences State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences Beijing Advanced Innovation Center for Genomics Biomedical Pioneering Innovation CenterCollege of Life SciencesPeking University CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences University of Chinese Academy of Sciences China National Center for Bioinformation

Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously, complicating the efforts to unravel the molecular drivers underlying endocrine Aging. To overcome these obstacles, we undertook single-cell RNA sequencing of pancreatic islet cells obtained from young and aged non-diabetic cynomolgus monkeys. Despite sex differences and increased transcriptional variations, aged β-cells showed increased unfolded protein response(UPR) along with the accumulation of protein aggregates. We observed transcriptomic dysregulation of UPR components linked to canonical ATF6 and IRE1 signaling pathways, comprising adaptive UPR during pancreatic Aging. Notably, we found Aging-related β-cell-specific upregulation of HSP90 B1, an endoplasmic reticulum-located chaperone, impeded high glucose-induced insulin secretion. Our work decodes Aging-associated transcriptomic changes that underlie pancreatic islet functional decay at single-cell resolution and indicates that targeting UPR components may prevent loss of proteostasis,suggesting an avenue to delaying β-cell Aging and preventing Aging-related diabetes.

关键词： islet β-cell Aging single-cell RNA sequencing primate

Change in elastic properties during room-temperature Aging in body-centered cubic Mg-Li and Mg-Li-Al single crystals

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Journal of Materials Science & Technology 2022年第14期109卷 49-53页

作者： Ruxia Liu Shota Higashino Koji Hagihara Lianmeng Zhang Tohru Sekino Masakazu Tane SANKEN(The Institute of Scientific and Industrial Research) Osaka University8-1 MihogaokaIbarakiOsaka 567-0047Japan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Graduate School of Engineering Osaka City University3-3-138 SugimotoOsaka558-8585Japan Department of Physical Science and Engineering Nagoya Institute of TechnologyNagoya 466-8555Japan

Biodegradable materials,with many advantages over conventionally used non-biodegradable materials,have received much attention owing to the elimination of the need for a secondary surgery for the removal of implants after implantation.Compared with other biodegradable ceramics and/or polymers,Mg alloys are considered to be the most promising biodegradable orthopedic materials because they feature not only high specific strength and compressive yield strength but also a low Young’s modulus,which is comparable to that of human bones(10-30 GPa)[1,2].

关键词： strength Aging alloys

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Identification and verification of Aging-related lncRNAs for prognosis prediction and immune microenvironment in patients with head and neck squamous carcinoma

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Oncology Research 2023年第1期31卷 35-61页

作者： QING GAO YUJING SHI YUANYUAN SUN SHU ZHOU ZEYUAN LIU XINCHEN SUN XIAOKE DI Department of Radiation Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China Department of Oncology Jurong People’s HospitalJurong212499China Department of Radiation Oncology Nanjing Jiangning Hospital and the Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing211199China

Aging is highly associated with tumor formation and progression.However,little research has explored the association of Aging-related lncRNAs(ARLs)with the prognosis and tumor immune microenvironment(TIME)of head and neck squamous cell carcinoma(HNSCC).RNA sequences and clinicopathological data of HNSCC patients and normal subjects were downloaded from The Cancer Genome Atlas.In the training group,we used Pearson correlation,univariate Cox regression,least absolute shrinkage/selection operator regression analyses,and multivariate Cox regression to build a prognostic model.In the test group,we evaluated the model.Multivariate Cox regression was done to screen out independent prognostic factors,with which we constructed a nomogram.Afterward,we demonstrated the predictive value of the risk scores based on the model and the nomogram using time-dependent receiver operating characteristics.Gene set enrichment analysis,immune correlation analysis,and half-maximal inhibitory concentration were also performed to reveal the different landscapes of TIME between risk groups and to predict immuno-and chemo-therapeutic responses.The most important LINC00861 in the model was examined in HNE1,CNE1,and CNE2 nasopharyngeal carcinoma cell lines and transfected into the cell lines CNE1 and CNE2 using the LINC00861-pcDNA3.1 construct plasmid.In addition,CCK-8,Edu,and SA-β-gal staining assays were conducted to test the biofunction of LINC00861 in the CNE1 and CNE2 cells.The signature based on nine ARLs has a good predictive value in survival time,immune infiltration,immune checkpoint expression,and sensitivity to multiple drugs.LINC00861 expression in CNE2 was significantly lower than in the HNE1 and CNE1 cells,and LINC00861 overexpression significantly inhibited the proliferation and increased the senescence of nasopharyngeal carcinoma cell lines.This work built and verified a new prognostic model for HNSCC based on ARLs and mapped the immune landscape in HNSCC.LINC00861 is a protective factor for the development of HNSCC.

关键词： Aging lncRNA HNSCC Prognosis Tumor immune microenvironment Bioinformatics

A single-cell transcriptome atlas of the Aging human and macaque retina

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National Science Review 2021年第4期8卷 48-65页

作者： Wenyang Yi Yufeng Lu Suijuan Zhong Mei Zhang Le Sun Hao Dong Mengdi Wang Min Wei Haohuan Xie Hongqiang Qu Rongmei Peng Jing Hong Ziqin Yao Yunyun Tong Wei Wang Qiang Ma Zeyuan Liu Yuqian Ma Shouzhen Li Chonghai Yin Jianwei Liu Chao Ma Xiaoqun Wang Qian Wu Tian Xue Institute for Stem Cell and Regeneration Chinese Academy of Sciences Advanced Innovation Center for Human Brain Protection Beijing Institute for Brain DisordersCapital Medical University Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences National Resource Center for Non-Human Primates(Kunming) Primate Research Center at IBP(Beijing) Chinese Academy of Sciences Eye Center at The First Affiliated Hospital of USTC Hefei National Laboratory for Physical Sciences at the MicroscaleSchool of Life Sciences Division of Life Sciences and Medicine University of Science and Technology of China State Key Laboratory of Brain and Cognitive Science Institute of Brain-Intelligence TechnologyBioland Laboratory Institute of Biophysics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University IDG/McGovern Institute for Brain Research Beijing Normal University Neurodegenerative Disorder Research Center CAS Key Laboratory of Brain Function and DiseaseUniversity of Science and Technology of China Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third Hospital Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Brain and Cognitive Science Institute of Brain-Intelligence Technology (Shanghai)Bioland Laboratory (Guangzhou) Institute of Biophysics Chinese Academy of Sciences

The human retina is a complex neural tissue that detects light and sends visual information to the brain.However, the molecular and cellular processes that underlie Aging primate retina remain unclear. Here, we provide a comprehensive transcriptomic atlas based on 119 520 single cells of the foveal and peripheral retina of humans and macaques covering different ages. The molecular features of retinal cells differed between the two species, suggesting distinct regional and species specializations of the human and macaque retinae. In addition, human retinal Aging occurred in a region-and cell-type-specific manner. Aging of human retina exhibited a foveal to peripheral gradient. MYO9A~-rods and a horizontal cell subtype were greatly reduced in Aging retina, indicating their vulnerability to Aging. Moreover, we generated a dataset showing the cell-type-and region-specific gene expression associated with 55 types of human retinal disease, which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases. Such datasets are valuable to understanding of the molecular characteristics of primate retina, as well as molecular regulation of Aging progression and related diseases.

关键词： single-cell RNA sequencing primate retina Aging cell heterogeneity age-related disease cell-cell communication

Association of symptomatic late-onset hypogonadism and lower urinary tract symptoms in Aging males: a community-based study

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Reproductive and Developmental Medicine 2023年第3期7卷 129-134页

作者： Guo-Qing Liang Jian-Hui Li Hui-Juan Shi Jun-Biao Zheng Xiao-Hua Yu Shu-Cheng Zhang Zheng Li Qian-Xi Zhu Yu-Xuan Song Feng Jiang Yong Zhu Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Department of Reproductive Epidemiology and Social Science NHC Key Lab of Reproduction RegulationShanghai Institute for Biomedical and Pharmaceutical TechnologiesFudan UniversityShanghai 200237China Department of Urology The First People's Hospital of JiashanZhejiang 314100China Department of Cell Biology National Research Institute of Family PlanningBejing 100081China Department of Andrology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Urology Peking University People's HospitalBejing 100044China.

Objective:Testosterone deficiency may be a risk factor for lower urinary tract symptoms(LUTS),and there may be a causal ink between the emergence of LUTS and the incidence of late-onset hypogonadism(LOH).We perfomed an epidemiologic study to investigate the association between symptomatic late-onset hypogonadism(SLOH)and LUTS in middle-aged and elderly rural Chinese males.Methods:A total of 965 men completed a questionnaire and underwent a detailed physical examination.The Aging Males'Symptoms(AMS)scale was used to assess SLOH,and the International Prostate Symptom Score(IPSS)questionnaire was used to assess LUTS.Serum reproductive hormone levels of testosterone,sex hormone-binding globulin(SHBG)and luteinizing hormone(LH)were measured.Results:A total of 965 males(mean age:56.34±8.85,range:40-80 years)were recruited for the present study.A total of 20.93%(202/965)were diagnosed with SLOH.A total of 93.16%(899/965)had mild LUTS,5.18%(50/965)had moderate LUTS,and 1.66%(16/965)had severe LUTS.Among SLOH patients,13.40%(27/202)and 3.90%(8/202)had moderate and severe LUTS,respectively.Patients with severe LUTS had increased SHBG and LH compared with those with mild and moderate LUTS(P<0.01).Correlation analysis revealed that the AMS total score was positively correlated with the IPSS score(P<0.05).The prevalence of SLOH was significantly increased with LUTS severity In addition to the known effect of age,the results of mutiple regression analysis also showed that serum LH or SHBG appeared to have a weak link with SLOH and LUTS that requires etiological and biological clarification in our future study.Conclusion:In this cross-sectional analysis of SLOH and LUTS,LUTS severity was significantly associated with hypogonadism symptoms.Additionally,the prevalence of SLOH advanced with increasing LUTS severity.Serum SHBG or LH showed a positive correlation with SLOH and LUTS.

关键词： Aging Hypogonadism Lower urinary tract symptoms Luteinizing hormone Sex hormone-binding globulin